| 1 |
FMR LLC |
5,452,061 |
133,030,000 |
24.18% |
|
|
| 2 |
FLAGSHIP VENTURES FUND IV GENERAL PARTNER LLC |
4,955,316 |
120,910,000 |
21.98% |
|
|
| 3 |
POLARIS VENTURE MANAGEMENT CO. VI, L.L.C. |
4,656,173 |
113,611,000 |
20.65% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,709,400 |
41,709,000 |
7.58% |
|
|
| 5 |
VIKING GLOBAL INVESTORS LP |
1,709,401 |
41,709,000 |
7.58% |
|
|
| 6 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,414,116 |
33,462,000 |
6.08% |
|
|
| 7 |
VANGUARD GROUP INC |
532,969 |
13,004,000 |
2.36% |
|
|
| 8 |
MORGAN STANLEY |
298,460 |
7,282,000 |
1.32% |
|
|
| 9 |
Capital World Investors |
295,000 |
7,198,000 |
1.31% |
|
|
| 10 |
Alphabet Inc. |
256,410 |
6,256,000 |
1.14% |
|
|
| 11 |
JENNISON ASSOCIATES LLC |
170,940 |
4,134,000 |
0.75% |
|
|
| 12 |
BlackRock Fund Advisors |
163,385 |
3,987,000 |
0.72% |
|
|
| 13 |
Omega Fund Management, LLC |
105,008 |
2,562,000 |
0.47% |
|
|
| 14 |
STATE STREET CORP |
100,234 |
2,447,000 |
0.44% |
|
|
| 15 |
EcoR1 Capital, LLC |
85,469 |
2,085,000 |
0.38% |
|
|
| 16 |
NORTHERN TRUST CORP |
73,023 |
1,782,000 |
0.32% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
65,931 |
1,609,000 |
0.29% |
|
|
| 18 |
Wildcat Capital Management, LLC |
59,800 |
1,459,000 |
0.27% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
56,769 |
1,385,000 |
0.25% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
50,641 |
1,236,000 |
0.22% |
|
|
| 21 |
Bank of New York Mellon Corp |
27,739 |
677,000 |
0.12% |
|
|
| 22 |
BlackRock Investment Management, LLC |
26,460 |
646,000 |
0.12% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
22,304 |
544,000 |
0.10% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
20,261 |
494,000 |
0.09% |
|
|
| 25 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,365 |
473,000 |
0.09% |
|
|
| 26 |
UBS Group AG |
17,291 |
422,000 |
0.08% |
|
|
| 27 |
ALLIANCEBERNSTEIN L.P. |
16,600 |
405,000 |
0.07% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
16,662 |
405,000 |
0.07% |
|
|
| 29 |
MILLENNIUM MANAGEMENT LLC |
15,660 |
382,000 |
0.07% |
|
|
| 30 |
Squarepoint Ops LLC |
15,400 |
376,000 |
0.07% |
|
|
| 31 |
SG Americas Securities, LLC |
14,597 |
356,000 |
0.06% |
|
|
| 32 |
SOCIETE GENERALE |
14,597 |
356,000 |
0.06% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,400 |
351,000 |
0.06% |
|
|
| 34 |
SCHONFELD STRATEGIC ADVISORS LLC |
14,312 |
349,000 |
0.06% |
|
|
| 35 |
Spark Investment Management LLC |
13,400 |
326,000 |
0.06% |
|
|
| 36 |
TD ASSET MANAGEMENT INC |
12,487 |
305,000 |
0.06% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
10,948 |
267,000 |
0.05% |
|
|
| 38 |
Paloma Partners Management Co |
10,333 |
252,000 |
0.05% |
|
|
| 39 |
Swiss National Bank |
9,900 |
242,000 |
0.04% |
|
|
| 40 |
CIM INVESTMENT MANAGEMENT INC |
9,366 |
229,000 |
0.04% |
|
|
| 41 |
BLACKROCK ADVISORS LLC |
8,827 |
215,000 |
0.04% |
|
|
| 42 |
METROPOLITAN LIFE INSURANCE CO/NY |
7,426 |
181,000 |
0.03% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,500 |
159,000 |
0.03% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
4,904 |
120,000 |
0.02% |
|
|
| 45 |
Nationwide Fund Advisors |
4,727 |
115,000 |
0.02% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
4,283 |
105,000 |
0.02% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,955 |
96,502 |
0.02% |
|
|
| 48 |
HOWARD HUGHES MEDICAL INSTITUTE |
3,145 |
77,000 |
0.01% |
|
|
| 49 |
STRS OHIO |
2,200 |
53,000 |
0.01% |
|
|
| 50 |
Creative Planning |
1,601 |
39,000 |
0.01% |
|
|
