| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,498,390 | 89,239,000 | 23.39% | ||
| 2 | POLARIS VENTURE MANAGEMENT CO. VI, L.L.C. | 3,797,146 | 61,628,000 | 16.15% | ||
| 3 | FLAGSHIP VENTURES MANAGEMENT, INC. | 3,455,316 | 56,080,000 | 14.70% | ||
| 4 | VIKING GLOBAL INVESTORS LP | 1,709,401 | 27,744,000 | 7.27% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,709,400 | 27,744,000 | 7.27% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,631,534 | 26,480,000 | 6.94% | ||
| 7 | VANGUARD GROUP INC | 1,316,384 | 21,365,000 | 5.60% | ||
| 8 | BlackRock Fund Advisors | 713,006 | 11,572,000 | 3.03% | ||
| 9 | EcoR1 Capital, LLC | 626,762 | 10,172,000 | 2.67% | ||
| 10 | Capital World Investors | 295,000 | 4,788,000 | 1.25% | ||
| 11 | FORESITE CAPITAL MANAGEMENT III, LLC | 274,910 | 4,462,000 | 1.17% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 260,639 | 4,230,000 | 1.11% | ||
| 13 | CREDIT SUISSE AG/ | 226,181 | 3,670,000 | 0.96% | ||
| 14 | MORGAN STANLEY | 208,324 | 3,381,000 | 0.89% | ||
| 15 | SABBY MANAGEMENT, LLC | 115,000 | 1,866,000 | 0.49% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 113,979 | 1,849,000 | 0.48% | ||
| 17 | STATE STREET CORP | 105,167 | 1,708,000 | 0.45% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 94,800 | 1,539,000 | 0.40% | ||
| 19 | NORGES BANK | 91,102 | 1,479,000 | 0.39% | ||
| 20 | HIGHLAND CAPITAL MANAGEMENT LP | 90,000 | 1,460,000 | 0.38% | ||
| 21 | NORTHERN TRUST CORP | 89,538 | 1,453,000 | 0.38% | ||
| 22 | CLARIUS GROUP, LLC | 87,231 | 1,416,000 | 0.37% | ||
| 23 | Omega Fund Management, LLC | 66,162 | 1,074,000 | 0.28% | ||
| 24 | CASDIN CAPITAL, LLC | 65,000 | 1,055,000 | 0.28% | ||
| 25 | CLOUGH CAPITAL PARTNERS L P | 50,400 | 818,000 | 0.21% | ||
| 26 | WELLS FARGO & COMPANY/MN | 49,619 | 806,000 | 0.21% | ||
| 27 | DRIEHAUS CAPITAL MANAGEMENT LLC | 46,580 | 756,000 | 0.20% | ||
| 28 | Bank of New York Mellon Corp | 41,429 | 672,000 | 0.18% | ||
| 29 | Wildcat Capital Management, LLC | 41,324 | 671,000 | 0.18% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 38,901 | 632,000 | 0.17% | ||
| 31 | HARBOURVEST PARTNERS LLC | 36,362 | 590,000 | 0.15% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,709 | 563,000 | 0.15% | ||
| 33 | TD ASSET MANAGEMENT INC | 30,970 | 503,000 | 0.13% | ||
| 34 | Swiss National Bank | 30,100 | 489,000 | 0.13% | ||
| 35 | GOLDMAN SACHS GROUP INC | 29,614 | 481,000 | 0.13% | ||
| 36 | BlackRock Investment Management, LLC | 26,397 | 428,000 | 0.11% | ||
| 37 | A.R.T. Advisors, LLC | 25,700 | 417,000 | 0.11% | ||
| 38 | ProShare Advisors LLC | 25,320 | 411,000 | 0.11% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 24,200 | 393,000 | 0.10% | ||
| 40 | VICTORY CAPITAL MANAGEMENT INC | 22,180 | 360,000 | 0.09% | ||
| 41 | BESSEMER GROUP INC | 21,818 | 354,000 | 0.09% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,678 | 336,000 | 0.09% | ||
| 43 | Squarepoint Ops LLC | 20,026 | 325,000 | 0.09% | ||
| 44 | SG Americas Securities, LLC | 19,641 | 319,000 | 0.08% | ||
| 45 | HAMILTON LANE ADVISORS LLC | 19,323 | 314,000 | 0.08% | ||
| 46 | D. E. Shaw & Co., Inc. | 18,277 | 297,000 | 0.08% | ||
| 47 | RUSSELL INVESTMENTS GROUP, LTD. | 17,647 | 284,000 | 0.07% | ||
| 48 | GROUP ONE TRADING LLC | 14,818 | 241,000 | 0.06% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14,200 | 230,000 | 0.06% | Call | |
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,100 | 229,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
