| 1 |
ORBIMED ADVISORS LLC |
9,127,990 |
28,571,000 |
35.39% |
|
|
| 2 |
FMR LLC |
7,989,923 |
25,008,000 |
30.97% |
|
|
| 3 |
Aisling Capital LLC |
7,480,887 |
23,415,000 |
29.00% |
|
|
| 4 |
VANGUARD GROUP INC |
421,876 |
1,320,000 |
1.63% |
|
|
| 5 |
BlackRock Fund Advisors |
214,190 |
670,000 |
0.83% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
81,656 |
256,000 |
0.32% |
|
|
| 7 |
NORTHERN TRUST CORP |
65,131 |
204,000 |
0.25% |
|
|
| 8 |
CARL DOMINO INC |
64,000 |
200,000 |
0.25% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
57,769 |
180,000 |
0.22% |
|
|
| 10 |
BUCKINGHAM STRATEGIC WEALTH, LLC |
50,000 |
157,000 |
0.19% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
39,289 |
123,000 |
0.15% |
|
|
| 12 |
STATE STREET CORP |
26,685 |
84,000 |
0.10% |
|
|
| 13 |
Sequoia Financial Advisors, LLC |
20,000 |
63,000 |
0.08% |
|
|
| 14 |
MORGAN STANLEY |
19,321 |
60,000 |
0.07% |
|
|
| 15 |
NEW YORK STATE COMMON RETIREMENT FUND |
13,932 |
44,000 |
0.05% |
|
|
| 16 |
Creative Planning |
14,000 |
44,000 |
0.05% |
|
|
| 17 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
13,819 |
43,000 |
0.05% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
12,781 |
40,000 |
0.05% |
|
|
| 19 |
SG Americas Securities, LLC |
12,930 |
40,000 |
0.05% |
|
|
| 20 |
Fiduciary Trust Co International of Pennsylvania |
11,750 |
37,000 |
0.05% |
|
|
| 21 |
Bank of New York Mellon Corp |
10,387 |
33,000 |
0.04% |
|
|
| 22 |
JPMORGAN CHASE & CO |
9,107 |
29,000 |
0.04% |
|
|
| 23 |
TEACHERS ADVISORS, LLC |
6,996 |
22,000 |
0.03% |
|
|
| 24 |
CITIGROUP INC |
6,484 |
20,000 |
0.02% |
|
|
| 25 |
BlackRock Investment Management, LLC |
5,969 |
19,000 |
0.02% |
|
|
| 26 |
UBS Group AG |
4,104 |
13,000 |
0.02% |
|
|
| 27 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,816 |
12,000 |
0.01% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
3,981 |
11,000 |
0.01% |
|
|
| 29 |
BLACKROCK ADVISORS LLC |
2,026 |
6,000 |
0.01% |
|
|
| 30 |
Nationwide Fund Advisors |
1,754 |
5,000 |
0.01% |
|
|
| 31 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,000 |
3,000 |
0.00% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
912 |
3,000 |
0.00% |
|
|
| 33 |
MEEDER ASSET MANAGEMENT INC |
624 |
2,000 |
0.00% |
|
|
| 34 |
BNP PARIBAS FINANCIAL MARKETS |
345 |
1,080 |
0.00% |
|
|
| 35 |
ROYAL BANK OF CANADA |
405 |
1,000 |
0.00% |
|
|
| 36 |
BARCLAYS PLC |
111 |
0 |
0.00% |
|
|
