| 1 |
NEA Management Company, LLC |
3,220,728 |
70,115,000 |
33.26% |
|
|
| 2 |
Abingworth LLP |
2,601,814 |
56,641,000 |
26.87% |
|
|
| 3 |
CLOUGH CAPITAL PARTNERS L P |
824,864 |
17,919,000 |
8.50% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
747,450 |
16,272,000 |
7.72% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
729,333 |
15,738,000 |
7.46% |
|
|
| 6 |
New Leaf Venture Partners, L.L.C. |
586,475 |
12,767,000 |
6.06% |
|
|
| 7 |
ORBIMED ADVISORS LLC |
372,191 |
8,103,000 |
3.84% |
|
|
| 8 |
Novo Holdings A/S |
223,317 |
4,862,000 |
2.31% |
|
|
| 9 |
VIVO CAPITAL, LLC |
148,878 |
3,241,000 |
1.54% |
|
|
| 10 |
CREDIT SUISSE AG/ |
80,000 |
1,742,000 |
0.83% |
|
|
| 11 |
PAULSON & CO. INC. |
50,500 |
1,099,000 |
0.52% |
|
|
| 12 |
MONASHEE INVESTMENT MANAGEMENT LLC |
22,186 |
473,000 |
0.22% |
|
PRN |
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
21,110 |
459,000 |
0.22% |
|
|
| 14 |
MORGAN STANLEY |
20,526 |
447,000 |
0.21% |
|
|
| 15 |
BANK OF AMERICA CORP /DE/ |
14,512 |
316,000 |
0.15% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
6,900 |
150,000 |
0.07% |
|
|
| 17 |
IHT WEALTH MANAGEMENT, LLC |
5,547 |
110,000 |
0.05% |
|
|
| 18 |
ROYAL BANK OF CANADA |
3,376 |
74,000 |
0.04% |
|
|
| 19 |
Daiwa SB Investments Ltd. |
2,800 |
61,000 |
0.03% |
|
|
| 20 |
THOMPSON DAVIS & CO., INC. |
2,500 |
54,000 |
0.03% |
|
|
| 21 |
BANK OF MONTREAL /CAN/ |
1,638 |
36,000 |
0.02% |
|
|
| 22 |
DUBUQUE BANK & TRUST CO |
1,425 |
31,000 |
0.01% |
|
|
| 23 |
WELLS FARGO & COMPANY/MN |
1,427 |
31,000 |
0.01% |
|
|
| 24 |
FEDERATION DES CAISSES DESJARDINS DU QUEBEC |
648 |
14,107 |
0.01% |
|
|
| 25 |
LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA |
600 |
13,000 |
0.01% |
|
|
| 26 |
UBS Group AG |
570 |
12,000 |
0.01% |
|
|
| 27 |
MOSAIC FAMILY WEALTH, LLC |
495 |
11,000 |
0.01% |
|
|
| 28 |
Carroll Financial Associates, Inc. |
450 |
9,000 |
0.00% |
|
|
| 29 |
INTELLECTUS PARTNERS, LLC |
425 |
9,000 |
0.00% |
|
|
| 30 |
ADVISOR GROUP, INC. |
300 |
7,000 |
0.00% |
|
|
| 31 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
100 |
2,000 |
0.00% |
|
|
| 32 |
Advisory Services Network, LLC |
100 |
2,000 |
0.00% |
|
|
| 33 |
CITIGROUP INC |
100 |
2,000 |
0.00% |
|
|
| 34 |
CRIBSTONE CAPITAL MANAGEMENT, LLC |
90 |
2,000 |
0.00% |
|
|
| 35 |
WESTSIDE INVESTMENT MANAGEMENT, INC. |
100 |
1,985 |
0.00% |
|
|
| 36 |
US BANCORP \DE\ |
39 |
1,000 |
0.00% |
|
|
