| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 5,815,940 | 85,055,000 | 9.35% | ||
| 2 | FMR LLC | 4,431,100 | 66,998,000 | 7.37% | ||
| 3 | Broadfin Capital, LLC | 4,305,469 | 65,099,000 | 7.16% | ||
| 4 | STATE STREET CORP | 2,911,990 | 44,030,000 | 4.84% | ||
| 5 | Murphy Michael R | 2,447,247 | 37,002,000 | 4.07% | ||
| 6 | BlackRock Fund Advisors | 2,336,738 | 35,331,000 | 3.88% | ||
| 7 | Visium Asset Management, LP | 2,238,000 | 33,839,000 | 3.72% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,032,364 | 30,709,000 | 3.38% | ||
| 9 | TimesSquare Capital Management, LLC | 1,582,800 | 23,932,000 | 2.63% | ||
| 10 | Invesco Ltd. | 1,424,408 | 21,537,000 | 2.37% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,310,930 | 19,821,000 | 2.18% | ||
| 12 | VANGUARD GROUP INC | 1,254,723 | 18,972,000 | 2.09% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,240,806 | 18,761,000 | 2.06% | ||
| 14 | CHARTWELL INVESTMENT PARTNERS/PA | 1,100,320 | 16,637,000 | 1.83% | ||
| 15 | OXFORD ASSET MANAGEMENT LLP | 1,063,027 | 16,073,000 | 1.77% | ||
| 16 | TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 15,120,000 | 1.66% | ||
| 17 | FRED ALGER MANAGEMENT, LLC | 962,340 | 14,551,000 | 1.60% | ||
| 18 | Allianz Asset Management GmbH | 931,470 | 14,084,000 | 1.55% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 902,400 | 13,644,000 | 1.50% | ||
| 20 | FRANKLIN RESOURCES INC | 861,100 | 13,020,000 | 1.43% | ||
| 21 | Alyeska Investment Group, L.P. | 850,000 | 12,852,000 | 1.41% | Call | |
| 22 | EMERALD ADVISERS, LLC | 817,410 | 12,359,000 | 1.36% | ||
| 23 | D. E. Shaw & Co., Inc. | 797,124 | 12,053,000 | 1.33% | ||
| 24 | CASTLEARK MANAGEMENT LLC | 710,928 | 10,749,000 | 1.18% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 663,692 | 10,035,000 | 1.10% | ||
| 26 | Lombard Odier Asset Management (USA) Corp | 650,000 | 9,828,000 | 1.08% | ||
| 27 | NORTHERN TRUST CORP | 649,931 | 9,827,000 | 1.08% | ||
| 28 | EMERALD MUTUAL FUND ADVISERS TRUST | 635,862 | 9,614,000 | 1.06% | ||
| 29 | Neuberger Berman Group LLC | 601,750 | 9,098,000 | 1.00% | ||
| 30 | DEUTSCHE BANK AG\ | 576,234 | 8,712,000 | 0.96% | ||
| 31 | MARSHALL WACE, LLP | 511,223 | 7,730,000 | 0.85% | ||
| 32 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 497,650 | 7,524,000 | 0.83% | ||
| 33 | Jefferies Group LLC | 482,100 | 7,289,000 | 0.80% | Call | |
| 34 | BARCLAYS PLC | 471,800 | 7,077,000 | 0.78% | Call | |
| 35 | Alyeska Investment Group, L.P. | 457,760 | 6,921,000 | 0.76% | ||
| 36 | MORGAN STANLEY | 435,515 | 6,584,000 | 0.72% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 434,625 | 6,572,000 | 0.72% | ||
| 38 | WASATCH ADVISORS LP | 406,557 | 6,147,000 | 0.68% | ||
| 39 | FULLER & THALER ASSET MANAGEMENT, INC. | 399,521 | 6,041,000 | 0.66% | ||
| 40 | CADENCE CAPITAL MANAGEMENT LLC | 383,790 | 5,803,000 | 0.64% | ||
| 41 | DECADE CAPITAL MANAGEMENT LLC | 381,662 | 5,771,000 | 0.63% | ||
| 42 | Bank of New York Mellon Corp | 356,505 | 5,391,000 | 0.59% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 352,800 | 5,334,000 | 0.59% | Call | |
| 44 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000 | 5,292,000 | 0.58% | ||
| 45 | GOLDMAN SACHS GROUP INC | 333,120 | 5,037,000 | 0.55% | ||
| 46 | GEODE CAPITAL MANAGEMENT, LLC | 321,940 | 4,867,000 | 0.54% | ||
| 47 | Iguana Healthcare Management, LLC | 320,000 | 4,838,000 | 0.53% | ||
| 48 | Informed Momentum Co LLC | 301,734 | 4,562,000 | 0.50% | ||
| 49 | GOLDMAN SACHS GROUP INC | 289,000 | 4,370,000 | 0.48% | Put | |
| 50 | WEXFORD CAPITAL LP | 283,777 | 4,291,000 | 0.47% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
