| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Essex Woodlands Management, Inc. | 5,815,940 | 88,982,000 | 8.92% | ||
| 2 | FMR LLC | 4,425,068 | 70,005,000 | 7.02% | ||
| 3 | Broadfin Capital, LLC | 4,353,214 | 68,868,000 | 6.91% | ||
| 4 | STATE STREET CORP | 3,070,378 | 48,572,000 | 4.87% | ||
| 5 | HealthCor Management, L.P. | 2,700,000 | 42,714,000 | 4.28% | ||
| 6 | Visium Asset Management, LP | 2,466,063 | 39,013,000 | 3.91% | ||
| 7 | Murphy Michael R | 2,417,854 | 38,250,000 | 3.84% | ||
| 8 | BlackRock Fund Advisors | 2,303,695 | 36,444,000 | 3.65% | ||
| 9 | TimesSquare Capital Management, LLC | 2,118,040 | 33,507,000 | 3.36% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,056,084 | 32,507,000 | 3.26% | ||
| 11 | VANGUARD GROUP INC | 1,674,716 | 26,494,000 | 2.66% | ||
| 12 | Invesco Ltd. | 1,162,575 | 18,393,000 | 1.84% | ||
| 13 | Allianz Asset Management GmbH | 1,154,972 | 18,272,000 | 1.83% | ||
| 14 | BENNETT LAWRENCE MANAGEMENT L L C/NY | 1,088,815 | 17,225,000 | 1.73% | ||
| 15 | NEW YORK STATE COMMON RETIREMENT FUND | 1,019,245 | 16,124,000 | 1.62% | ||
| 16 | TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 15,820,000 | 1.59% | ||
| 17 | CHARTWELL INVESTMENT PARTNERS, LLC | 981,113 | 15,521,000 | 1.56% | ||
| 18 | EMERALD ADVISERS, LLC | 907,591 | 14,358,000 | 1.44% | ||
| 19 | PRICE T ROWE ASSOCIATES INC /MD/ | 890,000 | 14,080,000 | 1.41% | ||
| 20 | Neuberger Berman Group LLC | 851,835 | 13,476,000 | 1.35% | ||
| 21 | Lombard Odier Asset Management (USA) Corp | 800,000 | 12,656,000 | 1.27% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 795,804 | 12,590,000 | 1.26% | ||
| 23 | TURNER INVESTMENTS LLC | 764,689 | 12,098,000 | 1.21% | ||
| 24 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 723,825 | 11,450,000 | 1.15% | ||
| 25 | NORTHERN TRUST CORP | 711,579 | 11,258,000 | 1.13% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 684,419 | 10,828,000 | 1.09% | ||
| 27 | CASTLEARK MANAGEMENT LLC | 667,503 | 10,560,000 | 1.06% | ||
| 28 | DRIEHAUS CAPITAL MANAGEMENT LLC | 663,842 | 10,502,000 | 1.05% | ||
| 29 | EMERALD MUTUAL FUND ADVISERS TRUST | 649,032 | 10,268,000 | 1.03% | ||
| 30 | DEERFIELD MANAGEMENT COMPANY, L.P. | 612,787 | 9,694,000 | 0.97% | ||
| 31 | OppenheimerFunds, Inc. | 588,993 | 9,318,000 | 0.93% | ||
| 32 | FRED ALGER MANAGEMENT, LLC | 563,899 | 8,921,000 | 0.89% | ||
| 33 | DEUTSCHE BANK AG\ | 552,510 | 8,739,000 | 0.88% | ||
| 34 | Jefferies Group LLC | 546,100 | 8,639,000 | 0.87% | Call | |
| 35 | ORBIMED ADVISORS LLC | 546,000 | 8,638,000 | 0.87% | ||
| 36 | INSIGHT CAPITAL RESEARCH & MANAGEMENT INC | 536,522 | 8,488,000 | 0.85% | ||
| 37 | MORGAN STANLEY | 454,600 | 7,192,000 | 0.72% | ||
| 38 | BARCLAYS PLC | 471,800 | 7,077,000 | 0.71% | Call | |
| 39 | WASATCH ADVISORS LP | 410,701 | 6,497,000 | 0.65% | ||
| 40 | Bank of New York Mellon Corp | 406,896 | 6,437,000 | 0.65% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 384,600 | 6,084,000 | 0.61% | Call | |
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 340,395 | 5,385,000 | 0.54% | ||
| 43 | AMERIPRISE FINANCIAL INC | 322,067 | 5,095,000 | 0.51% | ||
| 44 | CADENCE CAPITAL MANAGEMENT LLC | 292,090 | 4,621,000 | 0.46% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 291,234 | 4,607,000 | 0.46% | ||
| 46 | FULLER & THALER ASSET MANAGEMENT, INC. | 286,493 | 4,532,000 | 0.45% | ||
| 47 | SG Americas Securities, LLC | 275,045 | 4,351,000 | 0.44% | ||
| 48 | Iguana Healthcare Management, LLC | 255,000 | 4,035,000 | 0.40% | ||
| 49 | D. E. Shaw & Co., Inc. | 248,260 | 3,927,000 | 0.39% | ||
| 50 | Tygh Capital Management, Inc. | 244,474 | 3,868,000 | 0.39% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
