| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,801,638 | 81,820,000 | 30.08% | ||
| 2 | Versant Venture Management, LLC | 1,806,832 | 30,788,417 | 11.32% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,403,653 | 23,918,000 | 8.79% | ||
| 4 | BlackRock Finance, Inc. | 885,766 | 15,095,000 | 5.55% | ||
| 5 | Redmile Group, LLC | 820,836 | 13,987,000 | 5.14% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 612,511 | 10,437,000 | 3.84% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 560,397 | 9,549,000 | 3.51% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 532,426 | 9,073,000 | 3.34% | ||
| 9 | Rock Springs Capital Management LP | 500,000 | 8,520,000 | 3.13% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 487,037 | 8,299,000 | 3.05% | ||
| 11 | VHCP MANAGEMENT II, LLC | 458,882 | 7,819,000 | 2.87% | ||
| 12 | Cormorant Asset Management, LP | 424,660 | 7,236,000 | 2.66% | ||
| 13 | FRANKLIN RESOURCES INC | 367,100 | 6,255,000 | 2.30% | ||
| 14 | FMR LLC | 331,000 | 5,640,000 | 2.07% | ||
| 15 | JENNISON ASSOCIATES LLC | 299,656 | 5,106,000 | 1.88% | ||
| 16 | VANGUARD GROUP INC | 294,575 | 5,019,000 | 1.85% | ||
| 17 | CASDIN CAPITAL, LLC | 260,000 | 4,430,000 | 1.63% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 225,000 | 3,834,000 | 1.41% | ||
| 19 | JPMORGAN CHASE & CO | 109,925 | 1,873,000 | 0.69% | ||
| 20 | Alyeska Investment Group, L.P. | 100,138 | 1,706,000 | 0.63% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 86,437 | 1,473,000 | 0.54% | ||
| 22 | VICTORY CAPITAL MANAGEMENT INC | 73,914 | 1,259,000 | 0.46% | ||
| 23 | STATE STREET CORP | 66,732 | 1,137,000 | 0.42% | ||
| 24 | FORESITE CAPITAL MANAGEMENT III, LLC | 66,553 | 1,134,000 | 0.42% | ||
| 25 | NORTHERN TRUST CORP | 54,492 | 929,000 | 0.34% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 44,420 | 756,000 | 0.28% | ||
| 27 | D. E. Shaw & Co., Inc. | 33,942 | 578,000 | 0.21% | ||
| 28 | Spark Investment Management LLC | 27,700 | 472,000 | 0.17% | ||
| 29 | TD ASSET MANAGEMENT INC | 24,682 | 421,000 | 0.15% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 23,399 | 399,000 | 0.15% | ||
| 31 | Bank of New York Mellon Corp | 18,843 | 321,000 | 0.12% | ||
| 32 | GOLDMAN SACHS GROUP INC | 18,391 | 313,000 | 0.12% | ||
| 33 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 17,060 | 291,000 | 0.11% | ||
| 34 | ARDSLEY ADVISORY PARTNERS LP | 12,572 | 214,000 | 0.08% | ||
| 35 | ProShare Advisors LLC | 12,257 | 209,000 | 0.08% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,800 | 201,000 | 0.07% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 11,532 | 197,000 | 0.07% | ||
| 38 | CITADEL ADVISORS LLC | 10,815 | 184,000 | 0.07% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,700 | 183,000 | 0.07% | ||
| 40 | MORGAN STANLEY | 9,124 | 156,000 | 0.06% | ||
| 41 | WELLS FARGO & COMPANY/MN | 7,747 | 132,000 | 0.05% | ||
| 42 | PERCEPTIVE ADVISORS LLC | 7,500 | 128,000 | 0.05% | ||
| 43 | TEACHERS ADVISORS, LLC | 6,085 | 104,000 | 0.04% | ||
| 44 | BARCLAYS PLC | 5,374 | 91,000 | 0.03% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 4,101 | 70,000 | 0.03% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 3,385 | 58,000 | 0.02% | ||
| 47 | Nationwide Fund Advisors | 2,210 | 38,000 | 0.01% | ||
| 48 | STRS OHIO | 1,800 | 30,000 | 0.01% | ||
| 49 | DEUTSCHE BANK AG\ | 1,579 | 25,000 | 0.01% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,145 | 20,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
