| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,801,638 | 85,517,000 | 31.44% | ||
| 2 | Versant Venture Management, LLC | 1,806,832 | 32,179,678 | 11.83% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,403,653 | 24,999,000 | 9.19% | ||
| 4 | Redmile Group, LLC | 916,626 | 14,903,000 | 5.48% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 707,426 | 12,599,000 | 4.63% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 565,838 | 10,078,000 | 3.70% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 579,681 | 10,028,000 | 3.69% | ||
| 8 | Rock Springs Capital Management LP | 485,000 | 8,638,000 | 3.18% | ||
| 9 | Cormorant Asset Management, LP | 449,660 | 8,008,000 | 2.94% | ||
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 442,000 | 7,872,000 | 2.89% | ||
| 11 | VHCP MANAGEMENT II, LLC | 458,882 | 7,267,000 | 2.67% | ||
| 12 | FRANKLIN RESOURCES INC | 367,100 | 6,538,000 | 2.40% | ||
| 13 | FMR LLC | 350,000 | 6,234,000 | 2.29% | ||
| 14 | JENNISON ASSOCIATES LLC | 298,586 | 5,318,000 | 1.95% | ||
| 15 | VANGUARD GROUP INC | 240,061 | 4,275,000 | 1.57% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 225,000 | 4,007,000 | 1.47% | ||
| 17 | BLACKROCK ADVISORS LLC | 200,072 | 3,564,000 | 1.31% | ||
| 18 | BlackRock Fund Advisors | 153,762 | 2,739,000 | 1.01% | ||
| 19 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 2,672,000 | 0.98% | ||
| 20 | JPMORGAN CHASE & CO | 130,566 | 2,325,000 | 0.85% | ||
| 21 | Alyeska Investment Group, L.P. | 121,735 | 2,168,000 | 0.80% | ||
| 22 | BlackRock Group LTD | 102,058 | 1,818,000 | 0.67% | ||
| 23 | FORESITE CAPITAL MANAGEMENT III, LLC | 66,553 | 1,185,000 | 0.44% | ||
| 24 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 58,416 | 1,040,000 | 0.38% | ||
| 25 | Omega Advisors Inc. | 45,800 | 816,000 | 0.30% | ||
| 26 | VICTORY CAPITAL MANAGEMENT INC | 36,000 | 641,000 | 0.24% | ||
| 27 | STATE STREET CORP | 35,500 | 632,000 | 0.23% | ||
| 28 | D. E. Shaw & Co., Inc. | 32,870 | 585,000 | 0.22% | ||
| 29 | BlackRock Finance, Inc. | 29,155 | 519,000 | 0.19% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 20,106 | 358,000 | 0.13% | ||
| 31 | RTW INVESTMENTS, LP | 20,000 | 356,000 | 0.13% | ||
| 32 | VHCP Management, LLC | 15,000 | 267,000 | 0.10% | ||
| 33 | Laurion Capital Management LP | 15,000 | 267,000 | 0.10% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 14,229 | 253,000 | 0.09% | ||
| 35 | BlackRock Investment Management, LLC | 14,233 | 253,000 | 0.09% | ||
| 36 | GOLDMAN SACHS GROUP INC | 12,604 | 224,000 | 0.08% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,200 | 217,000 | 0.08% | ||
| 38 | TD ASSET MANAGEMENT INC | 10,700 | 191,000 | 0.07% | ||
| 39 | BlackRock Institutional Trust Company, N.A. | 8,189 | 146,000 | 0.05% | ||
| 40 | PERCEPTIVE ADVISORS LLC | 7,500 | 134,000 | 0.05% | ||
| 41 | TEACHERS ADVISORS, LLC | 6,085 | 108,000 | 0.04% | ||
| 42 | STRS OHIO | 1,800 | 32,000 | 0.01% | ||
| 43 | UBS Group AG | 1,394 | 25,000 | 0.01% | ||
| 44 | DEUTSCHE BANK AG\ | 962 | 17,000 | 0.01% | ||
| 45 | CITIGROUP INC | 469 | 8,000 | 0.00% | ||
| 46 | Tower Research Capital LLC (TRC) | 370 | 7,000 | 0.00% | ||
| 47 | Catalyst Capital Advisors LLC | 230 | 4,000 | 0.00% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 206 | 3,669 | 0.00% | ||
| 49 | ROYAL BANK OF CANADA | 100 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
