| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,801,638 | 87,726,000 | 31.02% | ||
| 2 | Versant Venture Management, LLC | 1,806,832 | 33,010,821 | 11.67% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,403,653 | 25,645,000 | 9.07% | ||
| 4 | Redmile Group, LLC | 832,736 | 15,214,000 | 5.38% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 578,597 | 10,267,000 | 3.63% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 533,258 | 9,743,000 | 3.45% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 532,426 | 9,727,000 | 3.44% | ||
| 8 | Rock Springs Capital Management LP | 485,000 | 8,861,000 | 3.13% | ||
| 9 | BlackRock Fund Advisors | 478,418 | 8,741,000 | 3.09% | ||
| 10 | VHCP MANAGEMENT II, LLC | 458,882 | 8,246,000 | 2.92% | ||
| 11 | Cormorant Asset Management, LP | 449,660 | 8,215,000 | 2.90% | ||
| 12 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 442,000 | 8,075,000 | 2.86% | ||
| 13 | FRANKLIN RESOURCES INC | 367,100 | 6,707,000 | 2.37% | ||
| 14 | FMR LLC | 350,000 | 6,395,000 | 2.26% | ||
| 15 | JENNISON ASSOCIATES LLC | 299,656 | 5,475,000 | 1.94% | ||
| 16 | VANGUARD GROUP INC | 272,292 | 4,975,000 | 1.76% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 225,000 | 4,111,000 | 1.45% | ||
| 18 | BLACKROCK ADVISORS LLC | 203,621 | 3,720,000 | 1.32% | ||
| 19 | JPMORGAN CHASE & CO | 123,840 | 2,263,000 | 0.80% | ||
| 20 | BlackRock Group LTD | 102,058 | 1,865,000 | 0.66% | ||
| 21 | Alyeska Investment Group, L.P. | 99,895 | 1,825,000 | 0.65% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 87,755 | 1,603,000 | 0.57% | ||
| 23 | FORESITE CAPITAL MANAGEMENT III, LLC | 66,553 | 1,216,000 | 0.43% | ||
| 24 | STATE STREET CORP | 62,980 | 1,151,000 | 0.41% | ||
| 25 | NORTHERN TRUST CORP | 48,237 | 881,000 | 0.31% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 42,829 | 782,000 | 0.28% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 37,065 | 677,000 | 0.24% | ||
| 28 | BlackRock Finance, Inc. | 29,369 | 537,000 | 0.19% | ||
| 29 | VICTORY CAPITAL MANAGEMENT INC | 28,890 | 528,000 | 0.19% | ||
| 30 | D. E. Shaw & Co., Inc. | 20,008 | 366,000 | 0.13% | ||
| 31 | RTW INVESTMENTS, LP | 20,000 | 365,000 | 0.13% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 19,089 | 348,000 | 0.12% | ||
| 33 | GOLDMAN SACHS GROUP INC | 18,703 | 342,000 | 0.12% | ||
| 34 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 17,450 | 319,000 | 0.11% | ||
| 35 | BlackRock Investment Management, LLC | 17,417 | 318,000 | 0.11% | ||
| 36 | MORGAN STANLEY | 16,717 | 305,000 | 0.11% | ||
| 37 | ProShare Advisors LLC | 15,277 | 279,000 | 0.10% | ||
| 38 | VHCP Management, LLC | 15,000 | 274,000 | 0.10% | ||
| 39 | Bank of New York Mellon Corp | 13,834 | 253,000 | 0.09% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 11,866 | 217,000 | 0.08% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,800 | 216,000 | 0.08% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,700 | 196,000 | 0.07% | ||
| 43 | TD ASSET MANAGEMENT INC | 10,600 | 194,000 | 0.07% | ||
| 44 | SG Americas Securities, LLC | 7,569 | 138,000 | 0.05% | ||
| 45 | PERCEPTIVE ADVISORS LLC | 7,500 | 137,000 | 0.05% | ||
| 46 | TEACHERS ADVISORS, LLC | 6,085 | 111,000 | 0.04% | ||
| 47 | DEUTSCHE BANK AG\ | 4,007 | 71,000 | 0.03% | ||
| 48 | WELLS FARGO & COMPANY/MN | 2,047 | 37,000 | 0.01% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 1,900 | 35,000 | 0.01% | ||
| 50 | STRS OHIO | 1,800 | 32,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
