| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,064,575 | 37,527,000 | 22.28% | ||
| 2 | BAUPOST GROUP LLC/MA | 8,721,079 | 36,105,000 | 21.44% | ||
| 3 | Redmile Group, LLC | 4,072,424 | 16,860,000 | 10.01% | ||
| 4 | BVF INC/IL | 3,133,224 | 12,972,000 | 7.70% | ||
| 5 | EcoR1 Capital, LLC | 3,000,000 | 12,420,000 | 7.38% | ||
| 6 | Avoro Capital Advisors LLC | 1,821,248 | 7,540,000 | 4.48% | ||
| 7 | VANGUARD GROUP INC | 1,423,843 | 5,895,000 | 3.50% | ||
| 8 | FRANKLIN RESOURCES INC | 1,113,166 | 4,609,000 | 2.74% | ||
| 9 | Abingworth LLP | 925,000 | 3,830,000 | 2.27% | ||
| 10 | QVT Financial LP | 800,000 | 3,312,000 | 1.97% | ||
| 11 | Anson Funds Management LP | 670,929 | 2,778,000 | 1.65% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 581,210 | 2,406,000 | 1.43% | ||
| 13 | Polar Capital LLP | 550,000 | 2,277,000 | 1.35% | ||
| 14 | SANDIA HOLDINGS, LLC | 543,719 | 2,251,000 | 1.34% | ||
| 15 | BlackRock Finance, Inc. | 536,611 | 2,221,000 | 1.32% | ||
| 16 | GREAT POINT PARTNERS LLC | 377,900 | 1,565,000 | 0.93% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 342,351 | 1,417,000 | 0.84% | ||
| 18 | DEUTSCHE BANK AG\ | 293,787 | 1,215,000 | 0.72% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 252,934 | 1,047,000 | 0.62% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 225,621 | 934,000 | 0.55% | ||
| 21 | GOLDMAN SACHS GROUP INC | 205,178 | 849,000 | 0.50% | ||
| 22 | DAFNA Capital Management LLC | 185,259 | 767,000 | 0.46% | ||
| 23 | OXFORD ASSET MANAGEMENT LLP | 162,192 | 671,000 | 0.40% | ||
| 24 | SABBY MANAGEMENT, LLC | 161,670 | 669,000 | 0.40% | ||
| 25 | FT OPTIONS LLC | 143,429 | 594,000 | 0.35% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 138,080 | 572,000 | 0.34% | ||
| 27 | MORGAN STANLEY | 103,788 | 430,000 | 0.26% | ||
| 28 | HANDELSBANKEN FONDER AB | 84,000 | 348,000 | 0.21% | ||
| 29 | TFS CAPITAL LLC | 75,784 | 314,000 | 0.19% | ||
| 30 | NORTHERN TRUST CORP | 74,199 | 307,000 | 0.18% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,700 | 297,000 | 0.18% | Call | |
| 32 | D. E. Shaw & Co., Inc. | 66,659 | 276,000 | 0.16% | ||
| 33 | Segantii Capital Management Ltd | 58,647 | 243,000 | 0.14% | ||
| 34 | ACADIAN ASSET MANAGEMENT LLC | 57,525 | 238,000 | 0.14% | ||
| 35 | PERKINS CAPITAL MANAGEMENT INC | 48,129 | 199,000 | 0.12% | ||
| 36 | SHEPHERD KAPLAN KROCHUK, LLC | 38,609 | 160,000 | 0.10% | ||
| 37 | Squarepoint Ops LLC | 37,650 | 156,000 | 0.09% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 37,528 | 155,000 | 0.09% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 36,885 | 153,000 | 0.09% | ||
| 40 | CITADEL ADVISORS LLC | 34,115 | 142,000 | 0.08% | ||
| 41 | STATE STREET CORP | 33,889 | 140,000 | 0.08% | ||
| 42 | A.R.T. Advisors, LLC | 34,019 | 140,000 | 0.08% | ||
| 43 | DIMENSIONAL FUND ADVISORS LP | 32,229 | 133,000 | 0.08% | ||
| 44 | BlueCrest Capital Management Ltd | 29,400 | 122,000 | 0.07% | ||
| 45 | BARCLAYS PLC | 29,164 | 120,000 | 0.07% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 27,832 | 115,000 | 0.07% | ||
| 47 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 22,193 | 92,000 | 0.05% | ||
| 48 | Bank of New York Mellon Corp | 20,613 | 85,000 | 0.05% | ||
| 49 | Telemetry Investments, L.L.C. | 18,190 | 75,000 | 0.04% | ||
| 50 | RENAISSANCE TECHNOLOGIES LLC | 17,988 | 74,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
