| 1 |
Novo Holdings A/S |
2,024,448 |
60,733,000 |
19.16% |
|
|
| 2 |
Capital Research Global Investors |
1,180,600 |
35,418,000 |
11.17% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
1,059,795 |
31,794,000 |
10.03% |
|
|
| 4 |
COLUMBIA WANGER ASSET MANAGEMENT LLC |
553,847 |
16,615,000 |
5.24% |
|
|
| 5 |
WADDELL & REED FINANCIAL INC |
463,942 |
13,918,000 |
4.39% |
|
|
| 6 |
FMR LLC |
440,000 |
13,200,000 |
4.16% |
|
|
| 7 |
PERCEPTIVE ADVISORS LLC |
352,241 |
10,567,000 |
3.33% |
|
|
| 8 |
Point72 Asset Management, L.P. |
318,973 |
9,569,000 |
3.02% |
|
|
| 9 |
WELLS FARGO & COMPANY/MN |
304,624 |
9,139,000 |
2.88% |
|
|
| 10 |
Board of Trustees of The Leland Stanford Junior University |
253,302 |
7,599,000 |
2.40% |
|
|
| 11 |
Redmile Group, LLC |
228,800 |
6,864,000 |
2.17% |
|
|
| 12 |
BlackRock Fund Advisors |
227,657 |
6,830,000 |
2.15% |
|
|
| 13 |
York Capital Management Global Advisors, LLC |
225,392 |
6,762,000 |
2.13% |
|
|
| 14 |
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
209,539 |
6,286,000 |
1.98% |
|
|
| 15 |
JENNISON ASSOCIATES LLC |
205,294 |
6,159,000 |
1.94% |
|
|
| 16 |
LORD, ABBETT & CO. LLC |
195,501 |
5,865,000 |
1.85% |
|
|
| 17 |
FORESITE CAPITAL MANAGEMENT III, LLC |
166,210 |
4,986,000 |
1.57% |
|
|
| 18 |
AMERIPRISE FINANCIAL INC |
128,373 |
3,851,000 |
1.21% |
|
|
| 19 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
126,796 |
3,804,000 |
1.20% |
|
|
| 20 |
Ghost Tree Capital, LLC |
115,182 |
3,455,000 |
1.09% |
|
|
| 21 |
Elk Creek Partners, LLC |
110,595 |
3,318,000 |
1.05% |
|
|
| 22 |
PRICE T ROWE ASSOCIATES INC /MD/ |
105,530 |
3,166,000 |
1.00% |
|
|
| 23 |
NEXT CENTURY GROWTH INVESTORS LLC |
100,779 |
3,023,000 |
0.95% |
|
|
| 24 |
JANUS HENDERSON INVESTORS US LLC |
100,359 |
3,011,000 |
0.95% |
|
|
| 25 |
FEDERATED HERMES, INC. |
100,000 |
3,000,000 |
0.95% |
|
|
| 26 |
BLACKROCK ADVISORS LLC |
97,905 |
2,937,000 |
0.93% |
|
|
| 27 |
GILDER GAGNON HOWE & CO LLC |
97,605 |
2,928,000 |
0.92% |
|
|
| 28 |
ALLIANCEBERNSTEIN L.P. |
96,372 |
2,891,000 |
0.91% |
|
|
| 29 |
BlackRock Group LTD |
93,160 |
2,795,000 |
0.88% |
|
|
| 30 |
GEODE CAPITAL MANAGEMENT, LLC |
85,712 |
2,571,000 |
0.81% |
|
|
| 31 |
NORTHERN TRUST CORP |
84,315 |
2,529,000 |
0.80% |
|
|
| 32 |
VANGUARD GROUP INC |
78,194 |
2,345,000 |
0.74% |
|
|
| 33 |
LAZARD ASSET MANAGEMENT LLC |
71,400 |
2,142,000 |
0.68% |
|
|
| 34 |
STATE STREET CORP |
63,857 |
1,916,000 |
0.60% |
|
|
| 35 |
MILLENNIUM MANAGEMENT LLC |
62,019 |
1,861,000 |
0.59% |
|
|
| 36 |
Laurion Capital Management LP |
60,000 |
1,800,000 |
0.57% |
|
|
| 37 |
JPMORGAN CHASE & CO |
44,029 |
1,321,000 |
0.42% |
|
|
| 38 |
BlackRock Institutional Trust Company, N.A. |
31,456 |
944,000 |
0.30% |
|
|
| 39 |
BlackRock Investment Management, LLC |
25,195 |
756,000 |
0.24% |
|
|
| 40 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
24,700 |
741,000 |
0.23% |
|
|
| 41 |
MORGAN STANLEY |
23,279 |
698,000 |
0.22% |
|
|
| 42 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
20,836 |
626,000 |
0.20% |
|
|
| 43 |
Spark Investment Management LLC |
20,800 |
624,000 |
0.20% |
|
|
| 44 |
MONASHEE INVESTMENT MANAGEMENT LLC |
18,791 |
564,000 |
0.18% |
|
|
| 45 |
GOLDMAN SACHS GROUP INC |
17,989 |
540,000 |
0.17% |
|
|
| 46 |
Bank of New York Mellon Corp |
17,921 |
538,000 |
0.17% |
|
|
| 47 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
17,564 |
527,000 |
0.17% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
17,512 |
524,000 |
0.17% |
|
|
| 49 |
BlackRock Finance, Inc. |
14,819 |
445,000 |
0.14% |
|
|
| 50 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,800 |
444,000 |
0.14% |
|
|
