| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 3,493,636 | 74,380,000 | 25.04% | ||
| 2 | Novo Holdings A/S | 2,031,562 | 43,252,000 | 14.56% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,631,429 | 34,733,000 | 11.70% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,351,808 | 28,780,000 | 9.69% | ||
| 5 | Rock Springs Capital Management LP | 788,959 | 16,797,000 | 5.66% | ||
| 6 | VHCP MANAGEMENT II, LLC | 725,029 | 15,436,000 | 5.20% | ||
| 7 | FRANKLIN RESOURCES INC | 366,000 | 7,792,000 | 2.62% | ||
| 8 | BlackRock Finance, Inc. | 345,041 | 7,346,000 | 2.47% | ||
| 9 | Ghost Tree Capital, LLC | 300,000 | 6,387,000 | 2.15% | ||
| 10 | VANGUARD GROUP INC | 270,253 | 5,753,000 | 1.94% | ||
| 11 | ACUTA CAPITAL PARTNERS, LLC | 247,956 | 5,279,000 | 1.78% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 225,340 | 4,797,000 | 1.62% | ||
| 13 | JENNISON ASSOCIATES LLC | 202,500 | 4,311,000 | 1.45% | ||
| 14 | BAKER BROS. ADVISORS LP | 177,952 | 3,789,000 | 1.28% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 177,830 | 3,786,000 | 1.27% | ||
| 16 | JPMORGAN CHASE & CO | 149,468 | 3,182,000 | 1.07% | ||
| 17 | AMERIPRISE FINANCIAL INC | 142,061 | 3,024,000 | 1.02% | ||
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 141,000 | 3,002,000 | 1.01% | ||
| 19 | Redmile Group, LLC | 110,769 | 2,358,000 | 0.79% | ||
| 20 | STATE STREET CORP | 107,687 | 2,294,000 | 0.77% | ||
| 21 | FIL Ltd | 104,400 | 2,223,000 | 0.75% | ||
| 22 | EMORY UNIVERSITY | 103,606 | 2,206,000 | 0.74% | ||
| 23 | PERCEPTIVE ADVISORS LLC | 100,000 | 2,129,000 | 0.72% | ||
| 24 | NORTHERN TRUST CORP | 76,396 | 1,626,000 | 0.55% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 70,863 | 1,508,000 | 0.51% | ||
| 26 | GOLDMAN SACHS GROUP INC | 68,352 | 1,455,000 | 0.49% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 60,000 | 1,277,000 | 0.43% | ||
| 28 | Iguana Healthcare Management, LLC | 50,000 | 1,065,000 | 0.36% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 45,978 | 979,000 | 0.33% | ||
| 30 | D. E. Shaw & Co., Inc. | 37,844 | 806,000 | 0.27% | ||
| 31 | Spark Investment Management LLC | 32,900 | 700,000 | 0.24% | ||
| 32 | Bank of New York Mellon Corp | 24,051 | 512,000 | 0.17% | ||
| 33 | RUSSELL INVESTMENTS GROUP, LTD. | 20,951 | 446,000 | 0.15% | ||
| 34 | DEUTSCHE BANK AG\ | 18,483 | 392,000 | 0.13% | ||
| 35 | FRED ALGER MANAGEMENT, LLC | 18,000 | 383,000 | 0.13% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,500 | 351,000 | 0.12% | ||
| 37 | MONASHEE INVESTMENT MANAGEMENT LLC | 15,147 | 322,000 | 0.11% | PRN | |
| 38 | BALYASNY ASSET MANAGEMENT L.P. | 14,170 | 302,000 | 0.10% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,800 | 273,000 | 0.09% | ||
| 40 | MORGAN STANLEY | 10,836 | 231,000 | 0.08% | ||
| 41 | WELLS FARGO & COMPANY/MN | 9,455 | 202,000 | 0.07% | ||
| 42 | TEACHERS ADVISORS, LLC | 8,910 | 190,000 | 0.06% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,317 | 178,000 | 0.06% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 7,837 | 167,000 | 0.06% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 7,401 | 158,000 | 0.05% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 4,814 | 102,000 | 0.03% | ||
| 47 | BARCLAYS PLC | 3,370 | 72,000 | 0.02% | ||
| 48 | Nationwide Fund Advisors | 2,787 | 59,000 | 0.02% | ||
| 49 | STRS OHIO | 2,600 | 55,000 | 0.02% | ||
| 50 | UBS Group AG | 1,465 | 31,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
