| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 3,493,636 | 53,068,000 | 25.06% | ||
| 2 | Novo Holdings A/S | 2,031,562 | 30,859,000 | 14.57% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,574,979 | 23,923,000 | 11.30% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 1,190,270 | 18,080,000 | 8.54% | ||
| 5 | Rock Springs Capital Management LP | 826,000 | 12,547,000 | 5.93% | ||
| 6 | VHCP MANAGEMENT II, LLC | 542,500 | 8,241,000 | 3.89% | ||
| 7 | ACUTA CAPITAL PARTNERS, LLC | 377,909 | 5,740,000 | 2.71% | ||
| 8 | FRANKLIN RESOURCES INC | 366,000 | 5,560,000 | 2.63% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 323,630 | 4,916,000 | 2.32% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 252,940 | 3,842,000 | 1.81% | ||
| 11 | BlackRock Fund Advisors | 238,058 | 3,616,000 | 1.71% | ||
| 12 | VHCP Management, LLC | 232,500 | 3,532,000 | 1.67% | ||
| 13 | JENNISON ASSOCIATES LLC | 202,500 | 3,076,000 | 1.45% | ||
| 14 | AMERIPRISE FINANCIAL INC | 198,770 | 3,027,000 | 1.43% | ||
| 15 | Redmile Group, LLC | 180,310 | 2,739,000 | 1.29% | ||
| 16 | BAKER BROS. ADVISORS LP | 177,952 | 2,703,000 | 1.28% | ||
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,000 | 2,658,000 | 1.26% | ||
| 18 | JPMORGAN CHASE & CO | 166,816 | 2,534,000 | 1.20% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 165,000 | 2,506,000 | 1.18% | ||
| 20 | BLACKROCK ADVISORS LLC | 133,613 | 2,029,000 | 0.96% | ||
| 21 | FIL Ltd | 130,000 | 1,975,000 | 0.93% | ||
| 22 | VANGUARD GROUP INC | 99,775 | 1,515,000 | 0.72% | ||
| 23 | Ghost Tree Capital, LLC | 75,000 | 1,139,000 | 0.54% | ||
| 24 | BlackRock Group LTD | 74,653 | 1,134,000 | 0.54% | ||
| 25 | NORTHERN TRUST CORP | 74,188 | 1,127,000 | 0.53% | ||
| 26 | STATE STREET CORP | 69,688 | 1,060,000 | 0.50% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 65,341 | 992,000 | 0.47% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 61,888 | 940,000 | 0.44% | ||
| 29 | SPHERA FUNDS MANAGEMENT LTD. | 60,000 | 911,000 | 0.43% | ||
| 30 | Iguana Healthcare Management, LLC | 50,000 | 760,000 | 0.36% | ||
| 31 | D. E. Shaw & Co., Inc. | 41,400 | 629,000 | 0.30% | ||
| 32 | Laurion Capital Management LP | 40,000 | 608,000 | 0.29% | ||
| 33 | DEUTSCHE BANK AG\ | 28,635 | 432,000 | 0.20% | ||
| 34 | MORGAN STANLEY | 23,878 | 363,000 | 0.17% | ||
| 35 | NORGES BANK | 20,000 | 304,000 | 0.14% | ||
| 36 | BlackRock Finance, Inc. | 17,107 | 260,000 | 0.12% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,900 | 257,000 | 0.12% | ||
| 38 | MONASHEE INVESTMENT MANAGEMENT LLC | 15,147 | 230,000 | 0.11% | ||
| 39 | BlackRock Institutional Trust Company, N.A. | 14,770 | 224,000 | 0.11% | ||
| 40 | FRED ALGER MANAGEMENT, LLC | 14,654 | 223,000 | 0.11% | ||
| 41 | BALYASNY ASSET MANAGEMENT L.P. | 13,580 | 206,000 | 0.10% | ||
| 42 | Bank of New York Mellon Corp | 13,558 | 206,000 | 0.10% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,800 | 195,000 | 0.09% | ||
| 44 | BlackRock Investment Management, LLC | 11,099 | 169,000 | 0.08% | ||
| 45 | TEACHERS ADVISORS, LLC | 8,910 | 135,000 | 0.06% | ||
| 46 | CITIGROUP INC | 8,263 | 125,000 | 0.06% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 6,400 | 97,000 | 0.05% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 3,978 | 60,000 | 0.03% | ||
| 49 | WELLS FARGO & COMPANY/MN | 3,755 | 57,000 | 0.03% | ||
| 50 | BARCLAYS PLC | 3,479 | 52,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
