| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 1,948,554 | 16,407,000 | 15.27% | ||
| 2 | STONEPINE CAPITAL MANAGEMENT, LLC | 1,524,034 | 12,832,000 | 11.94% | ||
| 3 | ARMISTICE CAPITAL, LLC | 1,420,000 | 11,956,000 | 11.13% | ||
| 4 | SCOPIA CAPITAL MANAGEMENT LP | 1,169,912 | 9,851,000 | 9.17% | ||
| 5 | Sarissa Capital Management LP | 1,025,000 | 8,630,000 | 8.03% | ||
| 6 | Healthcare Value Capital, LLC | 831,440 | 7,001,000 | 6.52% | ||
| 7 | FMR LLC | 613,277 | 5,164,000 | 4.81% | ||
| 8 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 599,998 | 5,052,000 | 4.70% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 332,870 | 2,803,000 | 2.61% | ||
| 10 | JW Asset Management, LLC | 324,280 | 2,731,000 | 2.54% | ||
| 11 | Tiger Legatus Capital Management, LLC | 320,000 | 2,694,000 | 2.51% | ||
| 12 | LEVIN CAPITAL STRATEGIES, L.P. | 270,553 | 2,278,000 | 2.12% | ||
| 13 | K2 PRINCIPAL FUND, L.P. | 269,536 | 2,270,000 | 2.11% | ||
| 14 | GILDER GAGNON HOWE & CO LLC | 260,190 | 2,191,000 | 2.04% | ||
| 15 | Artal Group S.A. | 256,400 | 2,159,000 | 2.01% | ||
| 16 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 215,000 | 1,810,000 | 1.68% | Call | |
| 17 | DEERFIELD MANAGEMENT COMPANY, L.P. | 170,454 | 1,435,000 | 1.34% | ||
| 18 | Connor, Clark & Lunn Investment Management Ltd. | 169,235 | 1,418,000 | 1.32% | ||
| 19 | GOLDMAN SACHS GROUP INC | 111,013 | 935,000 | 0.87% | ||
| 20 | KNOTT DAVID M | 109,184 | 919,000 | 0.86% | ||
| 21 | ORBIMED ADVISORS LLC | 100,000 | 842,000 | 0.78% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,500 | 821,000 | 0.76% | Call | |
| 23 | DEUTSCHE BANK AG\ | 96,419 | 811,000 | 0.75% | ||
| 24 | D. E. Shaw & Co., Inc. | 72,520 | 611,000 | 0.57% | ||
| 25 | NORGES BANK | 70,935 | 594,000 | 0.55% | ||
| 26 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 40,492 | 341,000 | 0.32% | ||
| 27 | BRANDES INVESTMENT PARTNERS, LP | 38,582 | 325,000 | 0.30% | ||
| 28 | Jefferies Group LLC | 35,156 | 296,000 | 0.28% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 34,500 | 290,000 | 0.27% | ||
| 30 | CREDIT SUISSE AG/ | 28,386 | 239,000 | 0.22% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,400 | 239,000 | 0.22% | Put | |
| 32 | PRELUDE CAPITAL MANAGEMENT, LLC | 24,676 | 208,000 | 0.19% | ||
| 33 | VANGUARD GROUP INC | 24,780 | 208,000 | 0.19% | ||
| 34 | TWO SIGMA INVESTMENTS, LP | 23,795 | 200,000 | 0.19% | ||
| 35 | 1492 Capital Management LLC | 12,400 | 104,000 | 0.10% | ||
| 36 | CUTLER GROUP LLC / CA | 11,996 | 101,000 | 0.09% | ||
| 37 | WOLVERINE ASSET MANAGEMENT LLC | 10,400 | 87,000 | 0.08% | Put | |
| 38 | BlackRock Group LTD | 9,930 | 84,000 | 0.08% | ||
| 39 | Parallax Volatility Advisers, L.P. | 9,400 | 79,000 | 0.07% | Call | |
| 40 | BANK OF AMERICA CORP /DE/ | 8,750 | 74,000 | 0.07% | ||
| 41 | CITIGROUP INC | 7,015 | 59,000 | 0.05% | ||
| 42 | SIMPLEX TRADING, LLC | 6,168 | 51,000 | 0.05% | ||
| 43 | BlackRock Finance, Inc. | 5,502 | 46,000 | 0.04% | ||
| 44 | GROUP ONE TRADING LLC | 5,332 | 45,000 | 0.04% | ||
| 45 | JPMORGAN CHASE & CO | 3,852 | 32,000 | 0.03% | ||
| 46 | WOLVERINE ASSET MANAGEMENT LLC | 2,739 | 23,000 | 0.02% | ||
| 47 | CITIGROUP INC | 2,220 | 19,000 | 0.02% | Put | |
| 48 | UBS Group AG | 1,726 | 14,000 | 0.01% | ||
| 49 | MORGAN STANLEY | 1,543 | 13,000 | 0.01% | ||
| 50 | BANK OF MONTREAL /CAN/ | 1,006 | 10,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
