| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Broadfin Capital, LLC | 1,948,554 | 20,927,000 | 14.95% | ||
| 2 | ARMISTICE CAPITAL, LLC | 1,852,000 | 19,890,000 | 14.21% | ||
| 3 | STONEPINE CAPITAL MANAGEMENT, LLC | 1,560,487 | 16,760,000 | 11.97% | ||
| 4 | Sarissa Capital Management LP | 1,025,000 | 11,008,000 | 7.86% | ||
| 5 | Healthcare Value Capital, LLC | 831,440 | 8,930,000 | 6.38% | ||
| 6 | Opaleye Management Inc. | 730,000 | 7,840,000 | 5.60% | ||
| 7 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 625,268 | 6,716,000 | 4.80% | ||
| 8 | KINGSTOWN CAPITAL MANAGEMENT L.P. | 599,998 | 6,444,000 | 4.60% | ||
| 9 | FMR LLC | 581,477 | 6,245,000 | 4.46% | ||
| 10 | Tiger Legatus Capital Management, LLC | 447,852 | 4,810,000 | 3.44% | ||
| 11 | GILDER GAGNON HOWE & CO LLC | 331,599 | 3,561,000 | 2.54% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 327,550 | 3,518,000 | 2.51% | ||
| 13 | JW Asset Management, LLC | 310,299 | 3,333,000 | 2.38% | ||
| 14 | Artal Group S.A. | 256,400 | 2,754,000 | 1.97% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 190,110 | 2,042,000 | 1.46% | ||
| 16 | LEVIN CAPITAL STRATEGIES, L.P. | 183,795 | 1,974,000 | 1.41% | ||
| 17 | DEUTSCHE BANK AG\ | 172,922 | 1,856,000 | 1.33% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 115,310 | 1,238,000 | 0.88% | ||
| 19 | GOLDMAN SACHS GROUP INC | 112,902 | 1,213,000 | 0.87% | ||
| 20 | KNOTT DAVID M | 109,184 | 1,173,000 | 0.84% | ||
| 21 | ORBIMED ADVISORS LLC | 100,000 | 1,074,000 | 0.77% | ||
| 22 | TWO SIGMA INVESTMENTS, LP | 65,987 | 709,000 | 0.51% | ||
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 57,329 | 615,000 | 0.44% | ||
| 24 | MORGAN STANLEY | 56,286 | 604,000 | 0.43% | ||
| 25 | K2 PRINCIPAL FUND, L.P. | 49,350 | 530,000 | 0.38% | ||
| 26 | D. E. Shaw & Co., Inc. | 47,520 | 510,000 | 0.36% | ||
| 27 | NORGES BANK | 46,196 | 495,000 | 0.35% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 39,891 | 428,000 | 0.31% | ||
| 29 | Yakira Capital Management, Inc. | 36,428 | 391,000 | 0.28% | SH | |
| 30 | BRANDES INVESTMENT PARTNERS, LP | 34,828 | 374,000 | 0.27% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,000 | 236,000 | 0.17% | Call | |
| 32 | CREDIT SUISSE AG/ | 21,660 | 233,000 | 0.17% | ||
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,600 | 200,000 | 0.14% | ||
| 34 | PRELUDE CAPITAL MANAGEMENT, LLC | 18,091 | 194,000 | 0.14% | ||
| 35 | CUTLER GROUP LLC / CA | 15,119 | 162,000 | 0.12% | ||
| 36 | FRANKLIN RESOURCES INC | 12,287 | 132,000 | 0.09% | ||
| 37 | BlackRock Finance, Inc. | 11,619 | 125,000 | 0.09% | ||
| 38 | JPMORGAN CHASE & CO | 10,292 | 110,000 | 0.08% | ||
| 39 | STIFEL FINANCIAL CORP | 10,000 | 107,000 | 0.08% | ||
| 40 | GROUP ONE TRADING LLC | 9,873 | 106,000 | 0.08% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 8,047 | 87,000 | 0.06% | ||
| 42 | SIMPLEX TRADING, LLC | 6,819 | 73,000 | 0.05% | ||
| 43 | Creative Planning | 6,253 | 67,000 | 0.05% | ||
| 44 | CITIGROUP INC | 4,895 | 52,000 | 0.04% | ||
| 45 | THOMPSON DAVIS & CO., INC. | 2,430 | 26,000 | 0.02% | ||
| 46 | Walleye Trading LLC | 2,000 | 21,000 | 0.02% | ||
| 47 | FNY PARTNERS FUND LP | 1,100 | 11,000 | 0.01% | ||
| 48 | BANK OF MONTREAL /CAN/ | 1,006 | 11,000 | 0.01% | ||
| 49 | Tower Research Capital LLC (TRC) | 900 | 10,000 | 0.01% | ||
| 50 | UBS Group AG | 801 | 8,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
