| 1 |
BAUPOST GROUP LLC/MA |
3,013,848 |
22,453,000 |
25.31% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,142,466 |
15,961,000 |
17.99% |
|
|
| 3 |
EcoR1 Capital, LLC |
1,294,431 |
9,644,000 |
10.87% |
|
|
| 4 |
Sarissa Capital Management LP |
689,091 |
5,134,000 |
5.79% |
|
|
| 5 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
398,753 |
2,971,000 |
3.35% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
352,384 |
2,625,000 |
2.96% |
|
|
| 7 |
Cormorant Asset Management, LP |
350,000 |
2,608,000 |
2.94% |
|
|
| 8 |
VANGUARD GROUP INC |
334,920 |
2,495,000 |
2.81% |
|
|
| 9 |
Gruss Capital Management LP |
300,000 |
2,235,000 |
2.52% |
|
|
| 10 |
BlackRock Fund Advisors |
292,247 |
2,177,000 |
2.45% |
|
|
| 11 |
Rock Springs Capital Management LP |
275,000 |
2,049,000 |
2.31% |
|
|
| 12 |
JPMORGAN CHASE & CO |
176,000 |
1,311,000 |
1.48% |
|
|
| 13 |
ACUTA CAPITAL PARTNERS, LLC |
171,807 |
1,280,000 |
1.44% |
|
|
| 14 |
PUTNAM INVESTMENTS LLC |
149,500 |
1,114,000 |
1.26% |
|
|
| 15 |
STATE STREET CORP |
139,099 |
1,034,000 |
1.17% |
|
|
| 16 |
ARIEL INVESTMENTS, LLC |
134,425 |
1,001,000 |
1.13% |
|
|
| 17 |
MORGAN STANLEY |
132,090 |
984,000 |
1.11% |
|
|
| 18 |
AWM Investment Company, Inc. |
131,090 |
977,000 |
1.10% |
|
|
| 19 |
Leonard Capital Management, Inc. |
115,000 |
857,000 |
0.97% |
|
|
| 20 |
NORTHERN TRUST CORP |
112,620 |
839,000 |
0.95% |
|
|
| 21 |
Lombard Odier Asset Management (USA) Corp |
100,000 |
745,000 |
0.84% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
88,033 |
656,000 |
0.74% |
|
|
| 23 |
BLACKROCK ADVISORS LLC |
84,958 |
633,000 |
0.71% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
77,793 |
579,000 |
0.65% |
|
|
| 25 |
COLUMBUS CIRCLE INVESTORS |
72,990 |
544,000 |
0.61% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
70,515 |
525,000 |
0.59% |
|
|
| 27 |
JOHNSON INVESTMENT COUNSEL INC |
63,091 |
470,000 |
0.53% |
|
|
| 28 |
JACKSON PARK CAPITAL, LLC |
57,000 |
425,000 |
0.48% |
|
|
| 29 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
54,701 |
408,000 |
0.46% |
|
|
| 30 |
MILLENNIUM MANAGEMENT LLC |
50,640 |
377,000 |
0.42% |
|
|
| 31 |
Old West Investment Management, LLC |
44,226 |
329,000 |
0.37% |
|
|
| 32 |
Bank of New York Mellon Corp |
39,539 |
295,000 |
0.33% |
|
|
| 33 |
A.R.T. Advisors, LLC |
36,067 |
268,000 |
0.30% |
|
|
| 34 |
Connor, Clark & Lunn Investment Management Ltd. |
35,300 |
263,000 |
0.30% |
|
|
| 35 |
BlackRock Investment Management, LLC |
30,572 |
228,000 |
0.26% |
|
|
| 36 |
CREDIT SUISSE AG/ |
26,450 |
197,000 |
0.22% |
|
|
| 37 |
Virtu KCG Holdings LLC |
25,357 |
189,000 |
0.21% |
|
|
| 38 |
RENAISSANCE TECHNOLOGIES LLC |
20,400 |
152,000 |
0.17% |
|
|
| 39 |
TFS CAPITAL LLC |
20,453 |
152,000 |
0.17% |
|
|
| 40 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
19,393 |
144,000 |
0.16% |
|
|
| 41 |
NORTHERN CAPITAL MANAGEMENT LLC |
19,000 |
142,000 |
0.16% |
|
|
| 42 |
Norman Fields, Gottscho Capital Management, LLC |
16,750 |
125,000 |
0.14% |
|
|
| 43 |
Evanson Asset Management, LLC |
16,545 |
123,000 |
0.14% |
|
|
| 44 |
CITADEL ADVISORS LLC |
16,138 |
120,000 |
0.14% |
|
|
| 45 |
TEACHERS ADVISORS, LLC |
15,048 |
112,000 |
0.13% |
|
|
| 46 |
BlackRock Group LTD |
14,850 |
111,000 |
0.13% |
|
|
| 47 |
LPL Financial LLC |
14,594 |
109,000 |
0.12% |
|
|
| 48 |
Absolute Return Capital, LLC |
13,904 |
104,000 |
0.12% |
|
|
| 49 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
12,900 |
97,000 |
0.11% |
|
|
| 50 |
Nationwide Fund Advisors |
10,320 |
77,000 |
0.09% |
|
|
