| 1 |
BAUPOST GROUP LLC/MA |
3,013,848 |
21,519,000 |
25.54% |
|
|
| 2 |
JENNISON ASSOCIATES LLC |
2,147,182 |
15,331,000 |
18.20% |
|
|
| 3 |
EcoR1 Capital, LLC |
1,294,431 |
9,242,000 |
10.97% |
|
|
| 4 |
Sarissa Capital Management LP |
689,091 |
4,920,000 |
5.84% |
|
|
| 5 |
VANGUARD GROUP INC |
372,801 |
2,662,000 |
3.16% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
348,753 |
2,490,000 |
2.96% |
|
|
| 7 |
Gruss Capital Management LP |
330,000 |
2,356,000 |
2.80% |
|
|
| 8 |
Cormorant Asset Management, LP |
328,497 |
2,345,000 |
2.78% |
|
|
| 9 |
BlackRock Fund Advisors |
293,603 |
2,096,000 |
2.49% |
|
|
| 10 |
ARIEL INVESTMENTS, LLC |
283,600 |
2,025,000 |
2.40% |
|
|
| 11 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
279,204 |
1,994,000 |
2.37% |
|
|
| 12 |
Rock Springs Capital Management LP |
275,000 |
1,964,000 |
2.33% |
|
|
| 13 |
JPMORGAN CHASE & CO |
156,500 |
1,117,000 |
1.33% |
|
|
| 14 |
PUTNAM INVESTMENTS LLC |
149,500 |
1,067,000 |
1.27% |
|
|
| 15 |
STATE STREET CORP |
139,427 |
996,000 |
1.18% |
|
|
| 16 |
COLUMBUS CIRCLE INVESTORS |
124,765 |
891,000 |
1.06% |
|
|
| 17 |
Leonard Capital Management, Inc. |
117,068 |
836,000 |
0.99% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
114,700 |
819,000 |
0.97% |
|
|
| 19 |
NORTHERN TRUST CORP |
111,490 |
797,000 |
0.95% |
|
|
| 20 |
Ghost Tree Capital, LLC |
100,500 |
718,000 |
0.85% |
|
|
| 21 |
Lombard Odier Asset Management (USA) Corp |
92,434 |
660,000 |
0.78% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
87,354 |
624,000 |
0.74% |
|
|
| 23 |
BLACKROCK ADVISORS LLC |
85,651 |
612,000 |
0.73% |
|
|
| 24 |
BANK OF AMERICA CORP /DE/ |
76,044 |
542,000 |
0.64% |
|
|
| 25 |
ACUTA CAPITAL PARTNERS, LLC |
75,000 |
536,000 |
0.64% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
67,881 |
484,000 |
0.57% |
|
|
| 27 |
JOHNSON INVESTMENT COUNSEL INC |
62,700 |
447,000 |
0.53% |
|
|
| 28 |
JACKSON PARK CAPITAL, LLC |
57,000 |
407,000 |
0.48% |
|
|
| 29 |
Connor, Clark & Lunn Investment Management Ltd. |
47,800 |
341,000 |
0.40% |
|
|
| 30 |
Old West Investment Management, LLC |
44,016 |
314,000 |
0.37% |
|
|
| 31 |
Bank of New York Mellon Corp |
39,466 |
282,000 |
0.33% |
|
|
| 32 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
36,171 |
258,000 |
0.31% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
35,829 |
255,000 |
0.30% |
|
|
| 34 |
BlackRock Investment Management, LLC |
29,824 |
213,000 |
0.25% |
|
|
| 35 |
MILLENNIUM MANAGEMENT LLC |
28,806 |
206,000 |
0.24% |
|
|
| 36 |
MORGAN STANLEY |
27,594 |
197,000 |
0.23% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
27,290 |
195,000 |
0.23% |
|
|
| 38 |
NORTHERN CAPITAL MANAGEMENT LLC |
25,925 |
185,000 |
0.22% |
|
|
| 39 |
Nine Chapters Capital Management LLC |
24,400 |
174,000 |
0.21% |
|
|
| 40 |
A.R.T. Advisors, LLC |
23,395 |
167,000 |
0.20% |
|
|
| 41 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
19,393 |
138,000 |
0.16% |
|
|
| 42 |
LPL Financial LLC |
17,994 |
124,000 |
0.15% |
|
|
| 43 |
TEACHERS ADVISORS, LLC |
17,251 |
123,000 |
0.15% |
|
|
| 44 |
Norman Fields, Gottscho Capital Management, LLC |
16,750 |
120,000 |
0.14% |
|
|
| 45 |
Evanson Asset Management, LLC |
16,545 |
118,000 |
0.14% |
|
|
| 46 |
BlackRock Group LTD |
14,850 |
106,000 |
0.13% |
|
|
| 47 |
Nationwide Fund Advisors |
11,772 |
84,000 |
0.10% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,598 |
47,110 |
0.06% |
|
|
| 49 |
UBS Group AG |
4,347 |
31,000 |
0.04% |
|
|
| 50 |
PANAGORA ASSET MANAGEMENT INC |
3,895 |
28,000 |
0.03% |
|
|
