Dark
Light
System
Security
SHIRE PLC
SHIRE PLC. Institutional holdings reported to the SEC.

Institutional Holders (2015Q1)
Portfolio Summary: 369 Institutional holders with a total value of $11,453,491,006.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 PAULSON & CO. INC. 8,328,304 1,992,880,000 17.40%
2 JENNISON ASSOCIATES LLC 5,815,878 1,391,681,000 12.15%
3 FMR LLC 4,049,021 968,890,000 8.46%
4 WADDELL & REED FINANCIAL INC 2,616,132 626,014,000 5.47%
5 PRICE T ROWE ASSOCIATES INC /MD/ 1,478,092 353,693,000 3.09%
6 ORBIMED ADVISORS LLC 1,385,000 331,417,000 2.89%
7 LAZARD ASSET MANAGEMENT LLC 1,144,523 273,872,000 2.39%
8 Invesco Ltd. 1,080,438 258,538,000 2.26%
9 MORGAN STANLEY 1,013,146 242,435,000 2.12%
10 Boston Partners 964,890 230,888,000 2.02%
11 WELLS FARGO & COMPANY/MN 871,426 208,479,000 1.82%
12 GOLDMAN SACHS GROUP INC 857,965 205,302,000 1.79%
13 BLACKROCK ADVISORS LLC 779,794 186,596,000 1.63%
14 MILLENNIUM MANAGEMENT LLC 669,680 160,248,000 1.40%
15 ORBIS HOLDINGS LTD 655,647 156,890,000 1.37%
16 JPMORGAN CHASE & CO 643,201 153,910,000 1.34%
17 BlackRock Fund Advisors 626,452 149,904,000 1.31%
18 DEUTSCHE BANK AG\ 618,799 148,066,000 1.29%
19 DSM CAPITAL PARTNERS LLC 595,444 142,484,000 1.24%
20 Omega Advisors Inc. 500,192 119,691,000 1.05%
21 JANUS HENDERSON INVESTORS US LLC 448,957 107,431,000 0.94%
22 FRANKLIN RESOURCES INC 408,700 97,798,000 0.85%
23 Senator Investment Group LP 350,000 83,752,000 0.73%
24 M.D. Sass, LLC 338,344 80,962,000 0.71%
25 CADIAN CAPITAL MANAGEMENT, LP 319,900 76,549,000 0.67%
26 D. E. Shaw & Co., Inc. 300,482 71,902,000 0.63%
27 First Eagle Investment Management, LLC 294,539 70,480,000 0.62%
28 HARDING LOEVNER LP 272,276 65,153,000 0.57%
29 SUVRETTA CAPITAL MANAGEMENT, LLC 258,100 61,761,000 0.54%
30 PARAMETRIC PORTFOLIO ASSOCIATES LLC 254,665 60,939,000 0.53%
31 SECTORAL ASSET MANAGEMENT INC 248,859 59,549,000 0.52%
32 BlackRock Group LTD 246,197 58,912,000 0.51%
33 NORTHERN TRUST CORP 245,228 58,680,000 0.51%
34 NEW MOUNTAIN VANTAGE ADVISERS, L.L.C. 239,449 57,298,000 0.50%
35 RAINIER INVESTMENT MANAGEMENT LLC 235,995 56,469,000 0.49%
36 FRED ALGER MANAGEMENT, LLC 230,786 55,225,000 0.48%
37 ACADIAN ASSET MANAGEMENT LLC 229,820 54,993,000 0.48%
38 SUSQUEHANNA INTERNATIONAL GROUP, LLP 222,800 53,314,000 0.47% Put
39 MANAGED ACCOUNT ADVISORS LLC 220,159 52,682,000 0.46%
40 RENAISSANCE TECHNOLOGIES LLC 197,512 47,263,000 0.41%
41 Tiger Eye Capital LLC 188,572 45,123,000 0.39%
42 Allianz Asset Management GmbH 180,763 43,255,000 0.38%
43 CREDIT AGRICOLE S A 177,500 42,474,000 0.37%
44 PNC FINANCIAL SERVICES GROUP, INC. 173,281 41,465,000 0.36%
45 NORGES BANK 154,491 36,968,000 0.32%
46 Alyeska Investment Group, L.P. 148,660 35,573,000 0.31%
47 CAPITAL FUND MANAGEMENT S.A. 141,234 33,796,000 0.30%
48 Bank of New York Mellon Corp 139,356 33,346,000 0.29%
49 Hardman Johnston Global Advisors LLC 136,165 32,583,000 0.28%
50 Provident Investment Management, Inc. 134,375 32,155,000 0.28%
Page 1 of 8

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.