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VERTEX PHARMACEUTICALS INC
VERTEX PHARMACEUTICALS INC. Institutional holdings reported to the SEC.

Institutional Holders (2015Q3)
Portfolio Summary: 515 Institutional holders with a total value of $24,679,152,462.
#
Manager Name
Shares
Value ($)
%
Options
Notes
101 ProShare Advisors LLC 276,749 28,821,000 0.12%
102 HOLLAND CAPITAL MANAGEMENT LLC 264,393 27,534,000 0.11%
103 Candriam S.C.A. 262,845 27,374,000 0.11%
104 MANUFACTURERS LIFE INSURANCE COMPANY, THE 255,098 26,566,000 0.11%
105 VAN ECK ASSOCIATES CORP 251,151 26,155,000 0.11%
106 TIVERTON ASSET MANAGEMENT LLC 250,000 26,035,000 0.11%
107 UNITED SERVICES AUTOMOBILE ASSOCIATION 249,700 26,004,000 0.11%
108 MACQUARIE GROUP LTD 240,690 25,066,000 0.10%
109 UBS Group AG 233,257 24,291,000 0.10%
110 DekaBank Deutsche Girozentrale 232,377 23,721,000 0.10%
111 DIMENSIONAL FUND ADVISORS LP 225,605 23,489,000 0.10%
112 Chevy Chase Trust Holdings, LLC 200,394 20,869,000 0.08%
113 Tourbillon Capital Partners, L.P. 200,000 20,828,000 0.08%
114 ARROWGRASS CAPITAL PARTNERS (US) LP 199,200 20,745,000 0.08%
115 MORGAN STANLEY 197,385 20,556,000 0.08%
116 CLOUGH CAPITAL PARTNERS L P 196,950 20,510,000 0.08%
117 WELCH & FORBES LLC 193,306 20,131,000 0.08%
118 PROFUND ADVISORS LLC 188,107 19,589,000 0.08%
119 COLUMBUS CIRCLE INVESTORS 181,632 18,915,000 0.08%
120 BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp 181,387 18,890,000 0.08%
121 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 177,202 18,454,000 0.07%
122 HSBC HOLDINGS PLC 163,528 17,030,000 0.07%
123 STATE OF WISCONSIN INVESTMENT BOARD 162,075 16,878,000 0.07%
124 GATEWAY INVESTMENT ADVISERS LLC 161,724 16,842,000 0.07%
125 SUSQUEHANNA INTERNATIONAL GROUP, LLP 161,482 16,817,000 0.07%
126 Retirement Systems of Alabama 153,176 15,952,000 0.06%
127 JANUS HENDERSON GROUP PLC 150,317 15,647,000 0.06%
128 MILLENNIUM MANAGEMENT LLC 150,000 15,621,000 0.06% Put
129 GLG LLC 146,716 15,279,000 0.06%
130 METROPOLITAN LIFE INSURANCE CO/NY 142,953 14,887,000 0.06%
131 SEI INVESTMENTS CO 141,487 14,735,000 0.06%
132 BLUE JAY CAPITAL MANAGEMENT, LLC 138,138 14,386,000 0.06%
133 AVIVA PLC 134,961 14,054,000 0.06%
134 BANK OF MONTREAL /CAN/ 132,486 13,797,000 0.06%
135 CITIGROUP INC 131,995 13,748,000 0.06%
136 BARCLAYS PLC 128,919 13,407,000 0.05%
137 CANADA LIFE ASSURANCE Co 125,026 13,035,000 0.05%
138 EULAV Asset Management 122,000 12,705,000 0.05%
139 National Pension Service 119,773 12,473,000 0.05%
140 BNP PARIBAS FINANCIAL MARKETS 117,952 12,283,522 0.05%
141 Korea Investment CORP 115,958 12,075,000 0.05%
142 PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 115,464 12,024,000 0.05%
143 EDMOND DE ROTHSCHILD HOLDING S.A. 115,214 11,998,000 0.05%
144 ORBIMED ADVISORS LLC 115,000 11,976,000 0.05%
145 EDMOND DE ROTHSCHILD ASSET MANAGEMENT (FRANCE) 115,000 11,976,000 0.05%
146 CAISSE DE DEPOT ET PLACEMENT DU QUEBEC 108,100 11,258,000 0.05%
147 AMERICAN INTERNATIONAL GROUP, INC. 107,913 11,239,000 0.05%
148 SECTOR GAMMA AS 107,063 11,150,000 0.05%
149 Rhenman & Partners Asset Management AB 105,000 10,935,000 0.04%
150 AMP Capital Investors Ltd 108,411 10,823,000 0.04%
Page 3 of 11

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.