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VERTEX PHARMACEUT
VERTEX PHARMACEUT. Institutional holdings reported to the SEC.

Institutional Holders (2015Q4)
Portfolio Summary: 538 Institutional holders with a total value of $29,661,308,289.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 Capital World Investors 20,737,911 2,609,451,000 8.80%
2 PRICE T ROWE ASSOCIATES INC /MD/ 18,823,471 2,368,557,000 7.99%
3 FMR LLC 15,009,185 1,888,606,000 6.37%
4 WELLINGTON MANAGEMENT GROUP LLP 14,863,986 1,870,336,000 6.31%
5 VANGUARD GROUP INC 14,503,469 1,824,972,000 6.15%
6 JPMORGAN CHASE & CO 12,618,064 1,587,733,000 5.35%
7 STATE STREET CORP 9,801,580 1,233,325,000 4.16%
8 AMERIPRISE FINANCIAL INC 9,590,194 1,206,754,000 4.07%
9 Clearbridge Investments, LLC 7,712,258 970,433,000 3.27%
10 BlackRock Institutional Trust Company, N.A. 6,251,676 786,648,000 2.65%
11 BlackRock Fund Advisors 5,435,591 683,960,000 2.31%
12 WADDELL & REED FINANCIAL INC 4,987,763 627,610,000 2.12%
13 Invesco Ltd. 4,251,208 534,929,000 1.80%
14 Bank of New York Mellon Corp 3,598,438 452,792,000 1.53%
15 NORTHERN TRUST CORP 2,904,573 365,481,000 1.23%
16 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 2,902,738 365,251,000 1.23%
17 GOLDMAN SACHS GROUP INC 2,869,924 361,123,000 1.22%
18 WELLS FARGO & COMPANY/MN 2,610,825 328,521,000 1.11%
19 Winslow Capital Management, LLC 2,501,991 314,826,000 1.06%
20 FRED ALGER MANAGEMENT, LLC 2,282,291 287,180,000 0.97%
21 BlackRock Group LTD 2,150,949 270,654,000 0.91%
22 JENNISON ASSOCIATES LLC 2,083,792 262,204,000 0.88%
23 GEODE CAPITAL MANAGEMENT, LLC 1,945,339 244,269,000 0.82%
24 BLACKROCK ADVISORS LLC 1,851,260 232,944,000 0.79%
25 BANK OF AMERICA CORP /DE/ 1,786,568 224,804,000 0.76%
26 NORGES BANK 1,774,121 223,237,000 0.75%
27 TIAA CREF INVESTMENT MANAGEMENT LLC 1,591,762 200,291,000 0.68%
28 BlackRock Investment Management, LLC 1,518,732 191,102,000 0.64%
29 AMERICAN CENTURY COMPANIES INC 1,510,545 190,072,000 0.64%
30 VIKING GLOBAL INVESTORS LP 1,421,673 178,889,000 0.60%
31 ADAGE CAPITAL PARTNERS GP, L.L.C. 1,413,776 177,895,000 0.60%
32 MILLENNIUM MANAGEMENT LLC 1,400,137 176,179,000 0.59%
33 BB BIOTECH AG 1,365,445 171,814,000 0.58%
34 DEUTSCHE BANK AG\ 1,296,585 163,145,000 0.55%
35 THRIVENT FINANCIAL FOR LUTHERANS 1,055,092 132,762,000 0.45%
36 Tekla Capital Management LLC 1,033,503 130,046,000 0.44%
37 JANUS HENDERSON INVESTORS US LLC 1,023,030 128,728,000 0.43%
38 OppenheimerFunds, Inc. 1,016,185 127,867,000 0.43%
39 FIRST TRUST ADVISORS LP 979,725 123,279,000 0.42%
40 Legal & General Group Plc 976,442 122,865,000 0.41%
41 HOPLITE CAPITAL MANAGEMENT, L.P. 961,531 120,989,000 0.41%
42 FRANKLIN RESOURCES INC 872,700 109,812,000 0.37%
43 LAZARD ASSET MANAGEMENT LLC 785,410 98,826,000 0.33%
44 abrdn Investment Management Ltd 782,975 98,534,000 0.33%
45 AMUNDI ASSET MANAGEMENT US, INC. 767,325 96,553,000 0.33%
46 BlackRock Finance, Inc. 712,622 89,669,000 0.30%
47 CITADEL ADVISORS LLC 708,486 89,148,000 0.30%
48 SECTORAL ASSET MANAGEMENT INC 688,200 86,596,000 0.29%
49 ORBIMED ADVISORS LLC 673,000 84,684,000 0.29%
50 D. E. Shaw & Co., Inc. 662,524 83,366,000 0.28%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.