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VERTEX PHARMACEUT
VERTEX PHARMACEUT. Institutional holdings reported to the SEC.

Institutional Holders (2016Q1)
Portfolio Summary: 518 Institutional holders with a total value of $18,941,759,021.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 PRICE T ROWE ASSOCIATES INC /MD/ 25,008,493 1,987,925,000 10.49%
2 Capital World Investors 21,598,162 1,716,838,000 9.06%
3 FMR LLC 15,134,753 1,203,062,000 6.35%
4 VANGUARD GROUP INC 14,935,838 1,187,250,000 6.27%
5 WELLINGTON MANAGEMENT GROUP LLP 14,727,173 1,170,662,000 6.18%
6 JPMORGAN CHASE & CO 11,688,327 929,105,000 4.91%
7 STATE STREET CORP 9,790,008 778,214,000 4.11%
8 AMERIPRISE FINANCIAL INC 9,403,147 747,465,000 3.95%
9 Clearbridge Investments, LLC 7,623,324 605,978,000 3.20%
10 BlackRock Institutional Trust Company, N.A. 6,338,154 503,820,000 2.66%
11 BlackRock Fund Advisors 5,852,428 465,210,000 2.46%
12 WADDELL & REED FINANCIAL INC 4,561,643 362,605,000 1.91%
13 GOLDMAN SACHS GROUP INC 4,409,972 350,549,000 1.85%
14 Invesco Ltd. 3,325,110 264,314,000 1.40%
15 Bank of New York Mellon Corp 3,166,038 251,669,000 1.33%
16 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 2,953,715 234,790,000 1.24%
17 NORTHERN TRUST CORP 2,912,990 231,554,000 1.22%
18 BlackRock Group LTD 2,132,681 169,525,000 0.89%
19 GEODE CAPITAL MANAGEMENT, LLC 1,986,187 157,561,000 0.83%
20 WELLS FARGO & COMPANY/MN 1,979,217 157,328,000 0.83%
21 FRED ALGER MANAGEMENT, LLC 1,968,489 156,475,000 0.83%
22 ORBIMED ADVISORS LLC 1,869,400 148,599,000 0.78%
23 BLACKROCK ADVISORS LLC 1,855,988 147,532,000 0.78%
24 AMERICAN CENTURY COMPANIES INC 1,756,022 139,586,000 0.74%
25 BlackRock Investment Management, LLC 1,723,031 136,964,000 0.72%
26 NORGES BANK 1,720,494 136,763,000 0.72%
27 BANK OF AMERICA CORP /DE/ 1,467,300 116,635,000 0.62%
28 BB BIOTECH AG 1,365,445 108,539,000 0.57%
29 OppenheimerFunds, Inc. 1,235,305 98,193,000 0.52%
30 TIAA CREF INVESTMENT MANAGEMENT LLC 1,220,014 96,979,000 0.51%
31 DEUTSCHE BANK AG\ 1,194,474 94,943,000 0.50%
32 D. E. Shaw & Co., Inc. 1,146,335 91,122,000 0.48%
33 GENERAL ELECTRIC CO 1,110,952 88,310,000 0.47%
34 JENNISON ASSOCIATES LLC 1,054,142 83,794,000 0.44%
35 Tekla Capital Management LLC 1,033,503 82,153,000 0.43%
36 ADAGE CAPITAL PARTNERS GP, L.L.C. 1,023,376 81,348,000 0.43%
37 THRIVENT FINANCIAL FOR LUTHERANS 1,007,732 80,104,000 0.42%
38 Senator Investment Group LP 1,000,000 79,490,000 0.42%
39 TWO SIGMA INVESTMENTS, LP 995,248 79,112,000 0.42%
40 FRANKLIN RESOURCES INC 990,015 78,696,000 0.42%
41 LAZARD ASSET MANAGEMENT LLC 982,343 78,085,000 0.41%
42 Legal & General Group Plc 976,361 77,611,000 0.41%
43 TWO SIGMA ADVISERS, LP 945,666 75,171,000 0.40%
44 JANUS HENDERSON INVESTORS US LLC 898,666 71,436,000 0.38%
45 SECTORAL ASSET MANAGEMENT INC 896,479 71,261,000 0.38%
46 AMUNDI ASSET MANAGEMENT US, INC. 876,770 69,695,000 0.37%
47 Point72 Asset Management, L.P. 838,700 66,668,000 0.35%
48 abrdn Investment Management Ltd 777,628 61,848,000 0.33%
49 NEW YORK STATE COMMON RETIREMENT FUND 697,700 55,460,000 0.29%
50 MILLENNIUM MANAGEMENT LLC 679,656 54,026,000 0.29%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.