| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,820,000 | 94,328,000 | 17.33% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,137,550 | 61,403,000 | 11.28% | ||
| 3 | Consonance Capital Management LP | 2,666,354 | 52,181,000 | 9.59% | ||
| 4 | VICTORY CAPITAL MANAGEMENT INC | 1,328,678 | 26,002,000 | 4.78% | ||
| 5 | VANGUARD GROUP INC | 1,318,705 | 25,807,000 | 4.74% | ||
| 6 | BlackRock Fund Advisors | 1,132,907 | 22,171,000 | 4.07% | ||
| 7 | HUDSON EXECUTIVE CAPITAL LP | 1,085,600 | 21,245,000 | 3.90% | ||
| 8 | First Light Asset Management, LLC | 939,012 | 18,376,000 | 3.38% | ||
| 9 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 902,520 | 17,662,000 | 3.24% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 829,491 | 16,233,000 | 2.98% | ||
| 11 | Cortina Asset Management, LLC | 622,683 | 12,186,000 | 2.24% | ||
| 12 | EMERALD ADVISERS, LLC | 583,737 | 11,424,000 | 2.10% | ||
| 13 | STATE STREET CORP | 555,334 | 10,872,000 | 2.00% | ||
| 14 | DAFNA Capital Management LLC | 518,946 | 10,156,000 | 1.87% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 485,043 | 9,492,000 | 1.74% | ||
| 16 | WASATCH ADVISORS LP | 475,299 | 9,302,000 | 1.71% | ||
| 17 | LOOMIS SAYLES & CO L P | 444,653 | 8,702,000 | 1.60% | ||
| 18 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 439,054 | 8,592,000 | 1.58% | ||
| 19 | NORTHERN TRUST CORP | 422,776 | 8,273,000 | 1.52% | ||
| 20 | ROYCE & ASSOCIATES LP | 329,300 | 6,444,000 | 1.18% | ||
| 21 | DEUTSCHE BANK AG\ | 306,566 | 5,998,000 | 1.10% | ||
| 22 | Portolan Capital Management, LLC | 297,592 | 5,824,000 | 1.07% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 244,712 | 4,789,000 | 0.88% | ||
| 24 | Rothschild Capital Partners, LLC | 240,260 | 4,702,000 | 0.86% | ||
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | 180,000 | 3,523,000 | 0.65% | ||
| 26 | AXIOM INVESTORS LLC /DE | 178,304 | 3,489,000 | 0.64% | ||
| 27 | KOPP INVESTMENT ADVISORS LLC | 177,309 | 3,470,000 | 0.64% | ||
| 28 | Allianz Asset Management GmbH | 153,957 | 3,013,000 | 0.55% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 148,731 | 2,911,000 | 0.53% | ||
| 30 | Bank of New York Mellon Corp | 144,573 | 2,829,000 | 0.52% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 142,347 | 2,786,000 | 0.51% | ||
| 32 | D. E. Shaw & Co., Inc. | 132,995 | 2,603,000 | 0.48% | ||
| 33 | PERKINS CAPITAL MANAGEMENT INC | 127,750 | 2,500,000 | 0.46% | ||
| 34 | BlackRock Investment Management, LLC | 126,695 | 2,479,000 | 0.46% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 121,945 | 2,386,000 | 0.44% | ||
| 36 | MORGAN STANLEY | 110,394 | 2,161,000 | 0.40% | ||
| 37 | ESSEX INVESTMENT MANAGEMENT CO LLC | 108,928 | 2,132,000 | 0.39% | ||
| 38 | COLUMBUS CIRCLE INVESTORS | 104,179 | 2,039,000 | 0.37% | ||
| 39 | BLAIR WILLIAM & CO/IL | 99,035 | 1,938,000 | 0.36% | ||
| 40 | PERCEPTIVE ADVISORS LLC | 94,400 | 1,847,000 | 0.34% | ||
| 41 | MACQUARIE GROUP LTD | 87,496 | 1,712,000 | 0.31% | ||
| 42 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 83,570 | 1,635,000 | 0.30% | ||
| 43 | GMT CAPITAL CORP | 73,193 | 1,432,000 | 0.26% | ||
| 44 | TWO SIGMA ADVISERS, LP | 73,100 | 1,431,000 | 0.26% | ||
| 45 | TEACHERS ADVISORS, LLC | 71,668 | 1,403,000 | 0.26% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 69,759 | 1,365,000 | 0.25% | ||
| 47 | CREDIT SUISSE AG/ | 69,251 | 1,355,000 | 0.25% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,806 | 1,268,000 | 0.23% | ||
| 49 | RENAISSANCE TECHNOLOGIES LLC | 57,200 | 1,119,000 | 0.21% | ||
| 50 | Swiss National Bank | 51,100 | 1,000,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
