| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 25,556,122 | 144,137,000 | 21.55% | ||
| 2 | BAKER BROS. ADVISORS LP | 18,558,487 | 104,670,000 | 15.65% | ||
| 3 | FMR LLC | 13,304,800 | 75,039,000 | 11.22% | ||
| 4 | BlackRock Fund Advisors | 7,108,983 | 40,095,000 | 5.99% | ||
| 5 | STATE STREET CORP | 6,704,566 | 37,819,000 | 5.65% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 4,868,557 | 27,459,000 | 4.10% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 4,678,430 | 26,386,000 | 3.94% | ||
| 8 | VANGUARD GROUP INC | 4,582,561 | 25,846,000 | 3.86% | ||
| 9 | TimesSquare Capital Management, LLC | 3,965,253 | 22,364,000 | 3.34% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 2,675,514 | 15,090,000 | 2.26% | ||
| 11 | Artal Group S.A. | 2,000,000 | 11,280,000 | 1.69% | ||
| 12 | NORTHERN TRUST CORP | 1,948,823 | 10,991,000 | 1.64% | ||
| 13 | CITADEL ADVISORS LLC | 1,199,622 | 6,766,000 | 1.01% | ||
| 14 | TEACHERS ADVISORS, LLC | 1,097,985 | 6,193,000 | 0.93% | ||
| 15 | Artal Group S.A. | 1,000,000 | 5,640,000 | 0.84% | Call | |
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 1,000,000 | 5,640,000 | 0.84% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 880,233 | 4,964,000 | 0.74% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 874,800 | 4,934,000 | 0.74% | Put | |
| 19 | Bank of New York Mellon Corp | 834,603 | 4,707,000 | 0.70% | ||
| 20 | FIL Ltd | 815,855 | 4,601,000 | 0.69% | ||
| 21 | GOLDMAN SACHS GROUP INC | 744,155 | 4,197,000 | 0.63% | ||
| 22 | Rock Springs Capital Management LP | 700,000 | 3,948,000 | 0.59% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 696,783 | 3,930,000 | 0.59% | ||
| 24 | SECTOR GAMMA AS | 669,400 | 3,775,000 | 0.56% | ||
| 25 | BARCLAYS PLC | 680,585 | 3,404,000 | 0.51% | ||
| 26 | EverPoint Asset Management, LLC | 600,000 | 3,384,000 | 0.51% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 567,800 | 3,202,000 | 0.48% | Call | |
| 28 | TD ASSET MANAGEMENT INC | 502,881 | 2,836,000 | 0.42% | ||
| 29 | BlackRock Investment Management, LLC | 464,372 | 2,619,000 | 0.39% | ||
| 30 | GREAT POINT PARTNERS LLC | 450,000 | 2,538,000 | 0.38% | ||
| 31 | SABBY MANAGEMENT, LLC | 434,000 | 2,448,000 | 0.37% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 416,221 | 2,348,000 | 0.35% | ||
| 33 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 368,766 | 2,080,000 | 0.31% | ||
| 34 | DRIEHAUS CAPITAL MANAGEMENT LLC | 361,695 | 2,040,000 | 0.30% | ||
| 35 | Allianz Asset Management GmbH | 357,522 | 2,016,000 | 0.30% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 291,760 | 1,646,000 | 0.25% | ||
| 37 | VIRTUS CAPITAL ADVISERS, LLC | 290,129 | 1,636,000 | 0.24% | ||
| 38 | Alyeska Investment Group, L.P. | 278,318 | 1,570,000 | 0.23% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 258,100 | 1,456,000 | 0.22% | ||
| 40 | Iguana Healthcare Management, LLC | 250,000 | 1,410,000 | 0.21% | ||
| 41 | Invesco Ltd. | 227,923 | 1,285,000 | 0.19% | ||
| 42 | DEUTSCHE BANK AG\ | 203,681 | 1,147,000 | 0.17% | ||
| 43 | Point72 Asset Management, L.P. | 201,800 | 1,138,000 | 0.17% | ||
| 44 | HighTower Advisors, LLC | 199,703 | 1,126,000 | 0.17% | ||
| 45 | Informed Momentum Co LLC | 191,188 | 1,078,000 | 0.16% | ||
| 46 | Nicholas Investment Partners, LP | 179,921 | 1,015,000 | 0.15% | ||
| 47 | ProShare Advisors LLC | 174,922 | 987,000 | 0.15% | ||
| 48 | CREDIT SUISSE AG/ | 168,471 | 950,000 | 0.14% | ||
| 49 | Swiss National Bank | 166,100 | 937,000 | 0.14% | ||
| 50 | TFS CAPITAL LLC | 165,384 | 933,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
