| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 38,513,713 | 652,807,000 | 23.61% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 23,465,722 | 397,744,000 | 14.38% | ||
| 3 | VANGUARD GROUP INC | 8,989,968 | 152,380,000 | 5.51% | ||
| 4 | BlackRock Fund Advisors | 8,614,625 | 146,018,000 | 5.28% | ||
| 5 | WATER ISLAND CAPITAL LLC | 5,306,423 | 89,943,870 | 3.25% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 4,968,630 | 84,218,000 | 3.05% | ||
| 7 | STATE STREET CORP | 4,931,809 | 83,594,000 | 3.02% | ||
| 8 | FMR LLC | 4,667,500 | 79,115,000 | 2.86% | ||
| 9 | OXFORD ASSET MANAGEMENT LLP | 4,008,100 | 67,737,000 | 2.45% | ||
| 10 | AQR CAPITAL MANAGEMENT LLC | 3,898,656 | 66,082,000 | 2.39% | ||
| 11 | ALPINE ASSOCIATES MANAGEMENT INC. | 3,027,177 | 51,311,000 | 1.86% | ||
| 12 | Miura Global Management, LLC | 2,758,000 | 46,748,000 | 1.69% | ||
| 13 | Tyrus Capital S.A.M. | 2,295,000 | 38,900,000 | 1.41% | ||
| 14 | NORTHERN TRUST CORP | 2,026,900 | 34,355,000 | 1.24% | ||
| 15 | GABELLI FUNDS LLC | 1,986,189 | 33,666,000 | 1.22% | ||
| 16 | BARCLAYS PLC | 2,085,179 | 33,364,000 | 1.21% | ||
| 17 | JPMORGAN CHASE & CO | 1,690,342 | 28,651,000 | 1.04% | ||
| 18 | CREDIT SUISSE AG/ | 1,651,002 | 27,985,000 | 1.01% | ||
| 19 | Jefferies Group LLC | 1,521,986 | 25,798,000 | 0.93% | ||
| 20 | OMERS ADMINISTRATION Corp | 1,510,600 | 25,605,000 | 0.93% | ||
| 21 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 1,481,900 | 25,118,000 | 0.91% | ||
| 22 | MORGAN STANLEY | 1,392,136 | 23,597,000 | 0.85% | ||
| 23 | TimesSquare Capital Management, LLC | 1,227,503 | 20,806,000 | 0.75% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 1,112,115 | 18,850,000 | 0.68% | ||
| 25 | Rock Springs Capital Management LP | 1,100,000 | 18,645,000 | 0.67% | ||
| 26 | DEUTSCHE BANK AG\ | 1,061,123 | 17,985,000 | 0.65% | ||
| 27 | Bank of New York Mellon Corp | 1,038,102 | 17,596,000 | 0.64% | ||
| 28 | GLAZER CAPITAL, LLC | 1,004,815 | 17,032,000 | 0.62% | ||
| 29 | Pentwater Capital Management LP | 1,000,000 | 16,950,000 | 0.61% | ||
| 30 | ARROWGRASS CAPITAL PARTNERS (US) LP | 971,020 | 16,459,000 | 0.60% | ||
| 31 | RENAISSANCE TECHNOLOGIES LLC | 884,514 | 14,993,000 | 0.54% | ||
| 32 | TIG Advisors, LLC | 820,863 | 13,914,000 | 0.50% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 784,190 | 13,292,000 | 0.48% | ||
| 34 | Sandell Asset Management Corp. | 748,730 | 12,691,000 | 0.46% | ||
| 35 | GABELLI & Co INVESTMENT ADVISERS, INC. | 740,335 | 12,549,000 | 0.45% | ||
| 36 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 735,294 | 12,463,000 | 0.45% | ||
| 37 | GARDNER LEWIS ASSET MANAGEMENT L P | 716,994 | 12,153,000 | 0.44% | ||
| 38 | Verition Fund Management LLC | 703,900 | 11,931,000 | 0.43% | Call | |
| 39 | SG Americas Securities, LLC | 680,739 | 11,539,000 | 0.42% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 611,025 | 10,357,000 | 0.37% | ||
| 41 | GILDER GAGNON HOWE & CO LLC | 567,469 | 9,619,000 | 0.35% | ||
| 42 | BlackRock Investment Management, LLC | 555,479 | 9,415,000 | 0.34% | ||
| 43 | Alyeska Investment Group, L.P. | 553,190 | 9,377,000 | 0.34% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 518,515 | 8,789,000 | 0.32% | ||
| 45 | Artal Group S.A. | 500,000 | 8,475,000 | 0.31% | Call | |
| 46 | GAMCO INVESTORS, INC. ET AL | 493,524 | 8,365,000 | 0.30% | ||
| 47 | Magnetar Financial LLC | 485,000 | 8,221,000 | 0.30% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 411,600 | 6,977,000 | 0.25% | Put | |
| 49 | WOLVERINE ASSET MANAGEMENT LLC | 408,646 | 6,926,000 | 0.25% | ||
| 50 | ROYCE & ASSOCIATES LP | 405,100 | 6,866,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
