| 1 |
NEA Management Company, LLC |
10,362,694 |
9,948,000 |
34.92% |
|
|
| 2 |
PERCEPTIVE ADVISORS LLC |
3,108,808 |
2,987,000 |
10.48% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
2,590,673 |
2,490,000 |
8.74% |
|
|
| 4 |
VANGUARD GROUP INC |
2,470,485 |
2,374,000 |
8.33% |
|
|
| 5 |
RENAISSANCE TECHNOLOGIES LLC |
2,405,400 |
2,312,000 |
8.11% |
|
|
| 6 |
Sarissa Capital Management LP |
2,000,000 |
1,922,000 |
6.75% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
1,945,975 |
1,870,000 |
6.56% |
|
|
| 8 |
Cormorant Asset Management, LP |
1,087,715 |
1,045,000 |
3.67% |
|
|
| 9 |
Deer VI & Co. LLC |
675,242 |
648,000 |
2.27% |
|
|
| 10 |
NEXTHERA CAPITAL LP |
518,134 |
498,000 |
1.75% |
|
|
| 11 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
514,051 |
494,000 |
1.73% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
303,283 |
291,000 |
1.02% |
|
|
| 13 |
Spark Investment Management LLC |
292,800 |
281,000 |
0.99% |
|
|
| 14 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
289,229 |
278,000 |
0.98% |
|
|
| 15 |
DAFNA Capital Management LLC |
259,067 |
249,000 |
0.87% |
|
SH |
| 16 |
Cannell & Co. |
127,500 |
123,000 |
0.43% |
|
|
| 17 |
NORTHERN TRUST CORP |
102,170 |
98,000 |
0.34% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
95,403 |
92,000 |
0.32% |
|
|
| 19 |
TUDOR INVESTMENT CORP ET AL |
83,869 |
81,000 |
0.28% |
|
|
| 20 |
Bank of New York Mellon Corp |
77,460 |
75,000 |
0.26% |
|
|
| 21 |
Evercore Wealth Management, LLC |
38,881 |
37,000 |
0.13% |
|
|
| 22 |
Virtu KCG Holdings LLC |
34,968 |
34,000 |
0.12% |
|
|
| 23 |
Tower Research Capital LLC (TRC) |
33,843 |
33,000 |
0.12% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
33,400 |
32,000 |
0.11% |
|
|
| 25 |
STATE STREET CORP |
25,375 |
25,000 |
0.09% |
|
|
| 26 |
NOMURA HOLDINGS INC |
24,763 |
24,000 |
0.08% |
|
|
| 27 |
BlackRock Fund Advisors |
24,154 |
23,000 |
0.08% |
|
|
| 28 |
Connor, Clark & Lunn Investment Management Ltd. |
18,500 |
18,000 |
0.06% |
|
|
| 29 |
GUGGENHEIM CAPITAL LLC |
18,592 |
18,000 |
0.06% |
|
|
| 30 |
MILLENNIUM MANAGEMENT LLC |
17,435 |
17,000 |
0.06% |
|
|
| 31 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
15,100 |
15,000 |
0.05% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
13,305 |
13,000 |
0.05% |
|
|
| 33 |
Creative Planning |
13,000 |
12,000 |
0.04% |
|
|
| 34 |
UBS Group AG |
10,030 |
10,000 |
0.04% |
|
|
| 35 |
Edge Wealth Management LLC |
10,000 |
10,000 |
0.04% |
|
SH |
| 36 |
BANK OF AMERICA CORP /DE/ |
5,503 |
5,000 |
0.02% |
|
|
| 37 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,600 |
2,000 |
0.01% |
|
|
| 38 |
CUTLER GROUP LLC / CA |
2,963 |
2,000 |
0.01% |
|
|
| 39 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
1,000 |
1,000 |
0.00% |
|
|
| 40 |
WELLS FARGO & COMPANY/MN |
800 |
1,000 |
0.00% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,190 |
1,000 |
0.00% |
|
|
| 42 |
MORGAN STANLEY |
1,093 |
1,000 |
0.00% |
|
|
| 43 |
BlackRock Finance, Inc. |
669 |
1,000 |
0.00% |
|
|
| 44 |
CT Financial Advisors LLC |
800 |
769 |
0.00% |
|
|
| 45 |
ADVISOR GROUP, INC. |
467 |
0 |
0.00% |
|
|
| 46 |
FIRST MANHATTAN CO. LLC. |
1,000 |
0 |
0.00% |
|
|
| 47 |
US BANCORP \DE\ |
500 |
0 |
0.00% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
44 |
0 |
0.00% |
|
|
