| 1 |
NEA Management Company, LLC |
10,362,694 |
9,223,000 |
35.83% |
|
|
| 2 |
PERCEPTIVE ADVISORS LLC |
3,108,808 |
2,766,000 |
10.75% |
|
|
| 3 |
RENAISSANCE TECHNOLOGIES LLC |
2,595,400 |
2,310,000 |
8.97% |
|
|
| 4 |
New Leaf Venture Partners, L.L.C. |
2,590,673 |
2,306,000 |
8.96% |
|
|
| 5 |
VANGUARD GROUP INC |
2,420,586 |
2,154,000 |
8.37% |
|
|
| 6 |
Sarissa Capital Management LP |
2,000,000 |
1,780,000 |
6.91% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
1,945,975 |
1,732,000 |
6.73% |
|
|
| 8 |
Cormorant Asset Management, LP |
1,087,715 |
968,000 |
3.76% |
|
|
| 9 |
Deer VI & Co. LLC |
675,242 |
601,000 |
2.33% |
|
|
| 10 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
514,051 |
458,000 |
1.78% |
|
|
| 11 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
306,129 |
272,000 |
1.06% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
303,283 |
269,000 |
1.04% |
|
|
| 13 |
Spark Investment Management LLC |
232,657 |
207,000 |
0.80% |
|
|
| 14 |
Cannell & Co. |
127,500 |
113,000 |
0.44% |
|
|
| 15 |
NORTHERN TRUST CORP |
102,170 |
91,000 |
0.35% |
|
|
| 16 |
TUDOR INVESTMENT CORP ET AL |
83,869 |
75,000 |
0.29% |
|
|
| 17 |
Bank of New York Mellon Corp |
65,390 |
58,000 |
0.23% |
|
|
| 18 |
WOLVERINE TRADING LP /BD |
45,500 |
40,000 |
0.16% |
Call |
|
| 19 |
Tower Research Capital LLC (TRC) |
45,344 |
40,000 |
0.16% |
|
|
| 20 |
CITADEL ADVISORS LLC |
43,287 |
39,000 |
0.15% |
|
|
| 21 |
Evercore Wealth Management, LLC |
38,881 |
35,000 |
0.14% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
33,400 |
30,000 |
0.12% |
|
|
| 23 |
STATE STREET CORP |
25,375 |
22,000 |
0.09% |
|
|
| 24 |
CITADEL ADVISORS LLC |
18,600 |
17,000 |
0.07% |
Call |
|
| 25 |
ACADIAN ASSET MANAGEMENT LLC |
19,105 |
17,000 |
0.07% |
|
|
| 26 |
Connor, Clark & Lunn Investment Management Ltd. |
18,500 |
16,000 |
0.06% |
|
|
| 27 |
GUGGENHEIM CAPITAL LLC |
18,454 |
16,000 |
0.06% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
16,931 |
15,000 |
0.06% |
|
|
| 29 |
MILLENNIUM MANAGEMENT LLC |
14,804 |
13,000 |
0.05% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
13,305 |
12,000 |
0.05% |
|
|
| 31 |
WOLVERINE TRADING LP /BD |
12,000 |
11,000 |
0.04% |
|
|
| 32 |
BlackRock Fund Advisors |
12,492 |
11,000 |
0.04% |
|
|
| 33 |
Edge Wealth Management LLC |
10,000 |
9,000 |
0.03% |
|
SH |
| 34 |
BANK OF AMERICA CORP /DE/ |
5,500 |
5,000 |
0.02% |
|
|
| 35 |
Creative Planning |
3,000 |
3,000 |
0.01% |
|
|
| 36 |
CUTLER GROUP LLC / CA |
2,963 |
2,000 |
0.01% |
|
|
| 37 |
MSI Financial Services Inc |
1,000 |
1,000 |
0.00% |
|
|
| 38 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,190 |
1,000 |
0.00% |
|
|
| 39 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,000 |
1,000 |
0.00% |
|
|
| 40 |
BlackRock Finance, Inc. |
669 |
1,000 |
0.00% |
|
|
| 41 |
WELLS FARGO & COMPANY/MN |
800 |
1,000 |
0.00% |
|
|
| 42 |
CT Financial Advisors LLC |
800 |
712 |
0.00% |
|
|
| 43 |
ADVISOR GROUP, INC. |
467 |
0 |
0.00% |
|
|
| 44 |
MORGAN STANLEY |
593 |
0 |
0.00% |
|
|
| 45 |
UBS Group AG |
415 |
0 |
0.00% |
|
|
| 46 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
250 |
0 |
0.00% |
|
|
