| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 34,705,000 | 62,469,000 | 17.73% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 17,883,954 | 32,331,000 | 9.18% | ||
| 3 | WESTFIELD CAPITAL MANAGEMENT CO LP | 13,688,379 | 24,742,000 | 7.02% | ||
| 4 | STATE STREET CORP | 13,717,708 | 24,693,000 | 7.01% | ||
| 5 | Polar Capital LLP | 10,747,844 | 19,422,000 | 5.51% | ||
| 6 | VANGUARD GROUP INC | 9,134,611 | 16,442,000 | 4.67% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 8,020,933 | 14,498,000 | 4.11% | ||
| 8 | FRANKLIN RESOURCES INC | 7,879,100 | 14,182,000 | 4.03% | ||
| 9 | Broadfin Capital, LLC | 7,660,100 | 13,846,000 | 3.93% | ||
| 10 | FMR LLC | 7,400,352 | 13,321,000 | 3.78% | ||
| 11 | Bain Capital Public Equity Management, LLC | 7,150,036 | 12,924,000 | 3.67% | ||
| 12 | BlackRock Fund Advisors | 6,620,926 | 11,967,000 | 3.40% | ||
| 13 | PUTNAM INVESTMENTS LLC | 5,780,241 | 10,405,000 | 2.95% | ||
| 14 | HealthCor Management, L.P. | 4,794,984 | 8,667,000 | 2.46% | ||
| 15 | NORTHERN TRUST CORP | 3,356,191 | 6,067,000 | 1.72% | ||
| 16 | Amici Capital, LLC | 2,884,100 | 5,191,000 | 1.47% | ||
| 17 | D. E. Shaw & Co., Inc. | 2,285,442 | 4,114,000 | 1.17% | ||
| 18 | AMERIPRISE FINANCIAL INC | 2,122,372 | 3,820,000 | 1.08% | ||
| 19 | OXFORD ASSET MANAGEMENT LLP | 1,993,164 | 3,588,000 | 1.02% | ||
| 20 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,944,375 | 3,500,000 | 0.99% | ||
| 21 | PANAGORA ASSET MANAGEMENT INC | 1,824,373 | 3,284,000 | 0.93% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 1,546,589 | 2,795,000 | 0.79% | ||
| 23 | BLACKROCK ADVISORS LLC | 1,507,244 | 2,724,000 | 0.77% | ||
| 24 | BLAIR WILLIAM & CO/IL | 1,501,263 | 2,713,000 | 0.77% | ||
| 25 | MORGAN STANLEY | 1,454,429 | 2,628,000 | 0.75% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 1,425,746 | 2,566,000 | 0.73% | ||
| 27 | Bank of New York Mellon Corp | 1,399,710 | 2,530,000 | 0.72% | ||
| 28 | Rhenman & Partners Asset Management AB | 1,228,354 | 2,211,000 | 0.63% | ||
| 29 | KENNEDY CAPITAL MANAGEMENT LLC | 1,170,643 | 2,116,000 | 0.60% | ||
| 30 | Manatuck Hill Partners, LLC | 1,070,000 | 1,934,000 | 0.55% | ||
| 31 | DEUTSCHE BANK AG\ | 931,479 | 1,682,000 | 0.48% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 910,116 | 1,638,000 | 0.46% | ||
| 33 | BlackRock Investment Management, LLC | 748,634 | 1,353,000 | 0.38% | ||
| 34 | CADENCE CAPITAL MANAGEMENT LLC | 735,990 | 1,330,000 | 0.38% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 490,500 | 883,000 | 0.25% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 475,491 | 856,000 | 0.24% | ||
| 37 | MHR FUND MANAGEMENT LLC | 445,000 | 804,000 | 0.23% | ||
| 38 | HOWARD HUGHES MEDICAL INSTITUTE | 433,557 | 784,000 | 0.22% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 426,909 | 768,000 | 0.22% | ||
| 40 | TURNER INVESTMENTS LLC | 394,910 | 714,000 | 0.20% | ||
| 41 | TEACHERS ADVISORS, LLC | 319,395 | 575,000 | 0.16% | ||
| 42 | Neuberger Berman Group LLC | 315,000 | 569,000 | 0.16% | ||
| 43 | Swiss National Bank | 271,400 | 489,000 | 0.14% | ||
| 44 | ProShare Advisors LLC | 265,870 | 479,000 | 0.14% | ||
| 45 | Ghost Tree Capital, LLC | 247,340 | 447,000 | 0.13% | ||
| 46 | CREDIT SUISSE AG/ | 224,651 | 406,000 | 0.12% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 215,798 | 388,000 | 0.11% | ||
| 48 | PRICE T ROWE ASSOCIATES INC /MD/ | 205,800 | 370,000 | 0.11% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 202,370 | 364,000 | 0.10% | ||
| 50 | Nationwide Fund Advisors | 202,356 | 364,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
