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Institutional Investment Manager
Palo Alto Investors LP
Palo Alto Investors LP (CIK: 0001306923) incorporated in California, located at 101 University Ave, Palo Alto, CA. Institutional holdings reported to the SEC.

Institutional Holdings (2014Q2)
Portfolio Summary: 42 holdings with a total value of $1,342,913,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 INTERMUNE INC 5,134,058 226,669,000 16.88%
2 UNITED THERAPEUTICS 1,213,828 107,412,000 8.00%
3 LIVANOVA PLC 1,715,430 107,146,000 7.98%
4 CUBIST PHARMACEUTI 1,526,916 106,609,000 7.94%
5 AUXILIUM PHARMACEUTICALS INC 4,854,631 97,384,000 7.25%
6 BIOMARIN 915,587 56,959,000 4.24%
7 ABIOMED INC 2,207,489 55,496,000 4.13%
8 VANDA PHARMACEUTICALS INC COM 3,240,424 52,430,000 3.90%
9 STAAR SURGICAL CO 2,599,553 43,672,000 3.25%
10 SEQUENOM INC 9,810,442 37,966,000 2.83%
11 CLOVIS ONCOLOGY INC 915,321 37,903,000 2.82%
12 KYTHERA BIOPHARMACEUTICALS I 949,959 36,450,000 2.71%
13 AMAG PHARMACEUTICALS INC COM 1,614,536 33,453,000 2.49%
14 Anacor Pharmaceuticals Inc 1,661,612 29,460,000 2.19%
15 CELLADON CORP 1,468,300 23,522,000 1.75%
16 ALIMERA SCIENCES INC 3,634,984 21,737,000 1.62%
17 Questcor 218,995 20,255,000 1.51%
18 NPS Pharmaceuticals, Inc. 609,300 20,137,000 1.50%
19 INSMED INC COM PAR .01 962,101 19,223,000 1.43%
20 RIGEL PHARMACEUTICAL INC 5,180,101 18,804,000 1.40%
21 Momenta Pharmaceuticals Inc 1,455,176 17,579,000 1.31%
22 SHIRE PLC 63,700 15,001,000 1.12%
23 ARIAD PHARMACEUTICALS INC 2,275,603 14,496,000 1.08%
24 CELGENE CORP 155,180 13,327,000 0.99%
25 AMICUS THERAPEUTICS INC 3,971,576 13,265,000 0.99%
26 EXACT SCIENCES CORP 777,676 13,244,000 0.99%
27 GILEAD SCIENCES INC 154,400 12,801,000 0.95%
28 Allergan plc 73,900 12,505,000 0.93%
29 PROTHENA CORP PLC 534,018 12,042,000 0.90%
30 Orexigen Therapeutics, Inc. 1,931,324 11,936,000 0.89%
31 QLT INC 1,887,208 11,663,000 0.87%
32 ALIGN TECHNOLOGY INC 176,788 9,907,000 0.74%
33 MEDIVATION INC 122,900 9,473,000 0.71%
34 Intuitive Surgical Inc 18,400 7,577,000 0.56%
35 GERON CORP 1,259,500 4,043,000 0.30%
36 REVANCE THERAPEUTICS INC COM 91,669 3,117,000 0.23%
37 XOMA CORP DEL 624,900 2,868,000 0.21%
38 AVEO PHARMACEUTICALS INC 1,200,800 2,197,000 0.16%
39 HYPERION THERAPEUTICS INC 62,700 1,636,000 0.12%
40 SOPHIRIS BIO INC 292,900 656,000 0.05%
41 CYTOKINETICS INC 123,686 591,000 0.04%
42 BIOSPECIFICS TECHNOLOGIES CORP COM 11,184 302,000 0.02%

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001306923-14-000006, filed 2014.08.14).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.