| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 14,289,159 | 478,259,000 | 13.13% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,026,463 | 335,586,000 | 9.21% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 6,627,500 | 221,822,000 | 6.09% | ||
| 4 | ORBIMED ADVISORS LLC | 5,952,000 | 199,213,000 | 5.47% | ||
| 5 | VANGUARD GROUP INC | 5,520,813 | 184,782,000 | 5.07% | ||
| 6 | Palo Alto Investors LP | 4,418,662 | 147,893,000 | 4.06% | ||
| 7 | BAKER BROS. ADVISORS LP | 4,324,843 | 144,752,000 | 3.97% | ||
| 8 | BlackRock Fund Advisors | 3,579,033 | 119,790,000 | 3.29% | ||
| 9 | FIRST TRUST ADVISORS LP | 3,250,713 | 108,801,000 | 2.99% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,596,093 | 86,891,000 | 2.39% | ||
| 11 | STATE STREET CORP | 2,200,856 | 73,664,000 | 2.02% | ||
| 12 | PUTNAM INVESTMENTS LLC | 1,675,675 | 56,084,000 | 1.54% | ||
| 13 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,663,624 | 55,681,000 | 1.53% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,612,700 | 53,977,000 | 1.48% | Put | |
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,583,942 | 53,015,000 | 1.46% | ||
| 16 | CITADEL ADVISORS LLC | 1,459,722 | 48,857,000 | 1.34% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,414,700 | 47,350,000 | 1.30% | Call | |
| 18 | JPMORGAN CHASE & CO | 1,389,750 | 46,515,000 | 1.28% | ||
| 19 | NEA Management Company, LLC | 1,341,000 | 44,883,000 | 1.23% | ||
| 20 | FEDERATED HERMES, INC. | 1,331,205 | 44,556,000 | 1.22% | ||
| 21 | D. E. Shaw & Co., Inc. | 1,268,128 | 42,444,000 | 1.17% | ||
| 22 | NORTHERN TRUST CORP | 1,214,612 | 40,653,000 | 1.12% | ||
| 23 | Invesco Ltd. | 1,137,594 | 38,075,000 | 1.05% | ||
| 24 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,120,800 | 37,513,000 | 1.03% | ||
| 25 | LORD, ABBETT & CO. LLC | 1,075,416 | 35,994,000 | 0.99% | ||
| 26 | BARCLAYS PLC | 1,042,800 | 34,412,000 | 0.94% | Put | |
| 27 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,000,000 | 33,470,000 | 0.92% | Call | |
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 878,137 | 29,391,000 | 0.81% | ||
| 29 | BARCLAYS PLC | 830,700 | 27,413,000 | 0.75% | Call | |
| 30 | OAK RIDGE INVESTMENTS LLC | 812,291 | 27,187,000 | 0.75% | ||
| 31 | VOYA INVESTMENT MANAGEMENT LLC | 785,665 | 26,296,000 | 0.72% | ||
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 753,397 | 25,217,000 | 0.69% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 701,000 | 23,462,000 | 0.64% | Call | |
| 34 | BLACKROCK ADVISORS LLC | 696,339 | 23,307,000 | 0.64% | ||
| 35 | GOLDMAN SACHS GROUP INC | 662,073 | 22,160,000 | 0.61% | ||
| 36 | NORGES BANK | 618,614 | 20,705,000 | 0.57% | ||
| 37 | Visium Asset Management, LP | 602,456 | 20,165,000 | 0.55% | ||
| 38 | Lombard Odier Asset Management (USA) Corp | 600,000 | 20,082,000 | 0.55% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 545,216 | 18,248,000 | 0.50% | ||
| 40 | Polar Capital LLP | 543,074 | 18,176,000 | 0.50% | ||
| 41 | Bank of New York Mellon Corp | 519,141 | 17,376,000 | 0.48% | ||
| 42 | BARCLAYS PLC | 493,735 | 16,293,000 | 0.45% | ||
| 43 | OppenheimerFunds, Inc. | 473,240 | 15,839,000 | 0.43% | ||
| 44 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 450,000 | 15,062,000 | 0.41% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 418,290 | 14,000,000 | 0.38% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 416,131 | 13,928,000 | 0.38% | ||
| 47 | Rock Springs Capital Management LP | 410,000 | 13,723,000 | 0.38% | ||
| 48 | Hudson Bay Capital Management LP | 409,148 | 13,694,000 | 0.38% | ||
| 49 | EMERALD ADVISERS, LLC | 385,290 | 12,896,000 | 0.35% | ||
| 50 | Capital World Investors | 383,000 | 12,819,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
