| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 14,568,290 | 643,190,000 | 13.63% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,042,757 | 443,388,000 | 9.39% | ||
| 3 | VANGUARD GROUP INC | 5,855,803 | 258,533,000 | 5.48% | ||
| 4 | ORBIMED ADVISORS LLC | 5,425,200 | 239,523,000 | 5.08% | ||
| 5 | Palo Alto Investors LP | 5,134,058 | 226,669,000 | 4.80% | ||
| 6 | BAKER BROS. ADVISORS LP | 4,722,869 | 208,515,000 | 4.42% | ||
| 7 | PRIMECAP MANAGEMENT CO/CA/ | 4,525,925 | 199,820,000 | 4.23% | ||
| 8 | BlackRock Fund Advisors | 3,381,454 | 149,291,000 | 3.16% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,628,438 | 116,046,000 | 2.46% | ||
| 10 | FRANKLIN RESOURCES INC | 2,451,903 | 108,249,000 | 2.29% | ||
| 11 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,315,521 | 102,230,000 | 2.17% | ||
| 12 | FIRST TRUST ADVISORS LP | 2,038,138 | 89,984,000 | 1.91% | ||
| 13 | STATE STREET CORP | 1,995,683 | 88,118,000 | 1.87% | ||
| 14 | LORD, ABBETT & CO. LLC | 1,870,822 | 82,597,000 | 1.75% | ||
| 15 | Invesco Ltd. | 1,787,016 | 78,896,000 | 1.67% | ||
| 16 | BLACKROCK ADVISORS LLC | 1,410,667 | 62,281,000 | 1.32% | ||
| 17 | NEA Management Company, LLC | 1,341,000 | 59,205,000 | 1.25% | ||
| 18 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,301,860 | 57,477,000 | 1.22% | ||
| 19 | FEDERATED HERMES, INC. | 1,292,031 | 57,043,000 | 1.21% | ||
| 20 | CITADEL ADVISORS LLC | 1,194,658 | 52,744,000 | 1.12% | ||
| 21 | NORTHERN TRUST CORP | 1,157,631 | 51,109,000 | 1.08% | ||
| 22 | PUTNAM INVESTMENTS LLC | 1,108,389 | 48,936,000 | 1.04% | ||
| 23 | JPMORGAN CHASE & CO | 1,067,708 | 47,139,000 | 1.00% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,038,700 | 45,859,000 | 0.97% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 992,800 | 43,833,000 | 0.93% | Call | |
| 26 | D. E. Shaw & Co., Inc. | 901,169 | 39,787,000 | 0.84% | ||
| 27 | OAK RIDGE INVESTMENTS LLC | 817,155 | 36,072,000 | 0.76% | ||
| 28 | MORGAN STANLEY | 702,041 | 30,994,000 | 0.66% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 691,197 | 30,516,000 | 0.65% | ||
| 30 | Hudson Bay Capital Management LP | 650,839 | 28,735,000 | 0.61% | ||
| 31 | Visium Asset Management, LP | 631,255 | 27,870,000 | 0.59% | ||
| 32 | NORGES BANK | 618,614 | 27,312,000 | 0.58% | ||
| 33 | VOYA INVESTMENT MANAGEMENT LLC | 587,738 | 25,949,000 | 0.55% | ||
| 34 | Bank of New York Mellon Corp | 580,454 | 25,628,000 | 0.54% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 575,762 | 25,419,000 | 0.54% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 572,060 | 25,257,000 | 0.54% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 570,851 | 25,203,000 | 0.53% | ||
| 38 | Rock Springs Capital Management LP | 538,000 | 23,753,000 | 0.50% | ||
| 39 | GOLDMAN SACHS GROUP INC | 531,837 | 23,481,000 | 0.50% | ||
| 40 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 451,954 | 19,954,000 | 0.42% | ||
| 41 | Polar Capital LLP | 431,326 | 19,042,000 | 0.40% | ||
| 42 | BlackRock Group LTD | 427,429 | 18,870,000 | 0.40% | ||
| 43 | RENAISSANCE TECHNOLOGIES LLC | 426,129 | 18,814,000 | 0.40% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 425,634 | 18,792,000 | 0.40% | ||
| 45 | Capital World Investors | 383,000 | 16,909,000 | 0.36% | ||
| 46 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 366,758 | 16,192,000 | 0.34% | ||
| 47 | BlackRock Investment Management, LLC | 342,385 | 15,116,000 | 0.32% | ||
| 48 | BARCLAYS PLC | 335,500 | 14,762,000 | 0.31% | Call | |
| 49 | DEUTSCHE BANK AG\ | 324,856 | 14,339,000 | 0.30% | ||
| 50 | OppenheimerFunds, Inc. | 300,500 | 13,267,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
