| 1 |
PRIMECAP MANAGEMENT CO/CA/ |
4,475,700 |
10,205,000 |
25.67% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
2,786,783 |
6,354,000 |
15.98% |
|
|
| 3 |
First Eagle Investment Management, LLC |
1,746,591 |
3,982,000 |
10.02% |
|
|
| 4 |
FMR LLC |
1,576,666 |
3,595,000 |
9.04% |
|
|
| 5 |
BVF INC/IL |
1,162,000 |
2,649,000 |
6.66% |
|
|
| 6 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1,084,493 |
2,473,000 |
6.22% |
|
|
| 7 |
GREAT POINT PARTNERS LLC |
910,699 |
2,076,000 |
5.22% |
|
|
| 8 |
WALL STREET ASSOCIATES |
608,300 |
1,387,000 |
3.49% |
|
|
| 9 |
VANGUARD GROUP INC |
470,690 |
1,073,000 |
2.70% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
360,000 |
821,000 |
2.07% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
352,200 |
803,000 |
2.02% |
|
|
| 12 |
Opaleye Management Inc. |
320,000 |
730,000 |
1.84% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
245,301 |
559,000 |
1.41% |
|
|
| 14 |
Weiss Multi-Strategy Advisers LLC |
200,000 |
456,000 |
1.15% |
|
|
| 15 |
SSI INVESTMENT MANAGEMENT LLC |
173,360 |
394,000 |
0.99% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
140,281 |
318,000 |
0.80% |
|
|
| 17 |
NORTHERN TRUST CORP |
111,466 |
254,000 |
0.64% |
|
|
| 18 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
86,700 |
198,000 |
0.50% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
76,360 |
174,000 |
0.44% |
|
|
| 20 |
BLAIR WILLIAM & CO/IL |
74,635 |
170,000 |
0.43% |
|
|
| 21 |
Old West Investment Management, LLC |
58,838 |
134,000 |
0.34% |
|
|
| 22 |
Paloma Partners Management Co |
51,027 |
116,000 |
0.29% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
50,528 |
115,000 |
0.29% |
|
|
| 24 |
BANK OF AMERICA CORP /DE/ |
48,720 |
111,000 |
0.28% |
|
|
| 25 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
34,089 |
78,000 |
0.20% |
|
|
| 26 |
Nationwide Fund Advisors |
34,300 |
78,000 |
0.20% |
|
|
| 27 |
BlackRock Fund Advisors |
31,024 |
71,000 |
0.18% |
|
|
| 28 |
LMR Partners LLP |
25,780 |
58,000 |
0.15% |
|
|
| 29 |
Nine Chapters Capital Management LLC |
21,400 |
49,000 |
0.12% |
|
|
| 30 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
17,304 |
39,000 |
0.10% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
17,314 |
39,000 |
0.10% |
|
|
| 32 |
BARCLAYS PLC |
18,339 |
37,000 |
0.09% |
|
|
| 33 |
VALLEY WEALTH MANAGERS, INC. |
15,861 |
36,000 |
0.09% |
|
|
| 34 |
CREDIT SUISSE AG/ |
14,664 |
33,000 |
0.08% |
|
|
| 35 |
D. E. Shaw & Co., Inc. |
13,172 |
30,000 |
0.08% |
|
|
| 36 |
DIMENSIONAL FUND ADVISORS LP |
5,656 |
13,000 |
0.03% |
|
|
| 37 |
UBS AG |
5,747 |
13,000 |
0.03% |
|
|
| 38 |
BlackRock Investment Management, LLC |
5,338 |
12,000 |
0.03% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
5,262 |
12,000 |
0.03% |
|
|
| 40 |
MORGAN STANLEY |
2,304 |
5,000 |
0.01% |
|
|
| 41 |
CITIGROUP INC |
1,284 |
3,000 |
0.01% |
|
|
| 42 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
229 |
1,000 |
0.00% |
|
|
| 43 |
BANK OF MONTREAL /CAN/ |
310 |
1,000 |
0.00% |
|
|
