| 1 |
PRIMECAP MANAGEMENT CO/CA/ |
4,475,700 |
6,937,000 |
27.61% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,074,972 |
4,766,000 |
18.97% |
|
|
| 3 |
First Eagle Investment Management, LLC |
1,746,591 |
2,707,000 |
10.78% |
|
|
| 4 |
FMR LLC |
1,576,666 |
2,444,000 |
9.73% |
|
|
| 5 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1,534,477 |
2,378,000 |
9.47% |
|
|
| 6 |
BVF INC/IL |
1,162,000 |
1,801,000 |
7.17% |
|
|
| 7 |
VANGUARD GROUP INC |
533,792 |
827,000 |
3.29% |
|
|
| 8 |
SSI INVESTMENT MANAGEMENT LLC |
360,440 |
561,000 |
2.23% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
360,979 |
560,000 |
2.23% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
349,560 |
542,000 |
2.16% |
|
|
| 11 |
Weiss Multi-Strategy Advisers LLC |
200,000 |
310,000 |
1.23% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
126,866 |
197,000 |
0.78% |
|
|
| 13 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
86,700 |
134,000 |
0.53% |
|
|
| 14 |
BLAIR WILLIAM & CO/IL |
83,635 |
129,000 |
0.51% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
76,884 |
119,000 |
0.47% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
76,360 |
118,000 |
0.47% |
|
|
| 17 |
Old West Investment Management, LLC |
59,140 |
91,000 |
0.36% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
50,528 |
78,000 |
0.31% |
|
|
| 19 |
NORTHERN TRUST CORP |
40,670 |
63,000 |
0.25% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
39,596 |
60,000 |
0.24% |
|
|
| 21 |
Nationwide Fund Advisors |
34,300 |
53,000 |
0.21% |
|
|
| 22 |
BlackRock Fund Advisors |
28,916 |
45,000 |
0.18% |
|
|
| 23 |
Nine Chapters Capital Management LLC |
22,700 |
35,000 |
0.14% |
|
|
| 24 |
VALLEY WEALTH MANAGERS, INC. |
15,861 |
25,000 |
0.10% |
|
|
| 25 |
Virtu KCG Holdings LLC |
14,191 |
22,000 |
0.09% |
|
|
| 26 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
13,306 |
21,000 |
0.08% |
|
|
| 27 |
D. E. Shaw & Co., Inc. |
12,972 |
20,000 |
0.08% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
13,086 |
20,000 |
0.08% |
|
|
| 29 |
BARCLAYS PLC |
17,547 |
18,000 |
0.07% |
|
|
| 30 |
CITADEL ADVISORS LLC |
10,084 |
16,000 |
0.06% |
|
|
| 31 |
DIMENSIONAL FUND ADVISORS LP |
5,656 |
9,000 |
0.04% |
|
|
| 32 |
BlackRock Investment Management, LLC |
5,834 |
9,000 |
0.04% |
|
|
| 33 |
Tower Research Capital LLC (TRC) |
2,557 |
3,000 |
0.01% |
|
|
| 34 |
UBS AG |
2,190 |
3,000 |
0.01% |
|
|
| 35 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
229 |
0 |
0.00% |
|
|
