| 1 |
PRIMECAP MANAGEMENT CO/CA/ |
4,475,700 |
7,743,000 |
26.94% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
2,286,783 |
3,956,000 |
13.76% |
|
|
| 3 |
First Eagle Investment Management, LLC |
1,746,591 |
3,022,000 |
10.51% |
|
|
| 4 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
1,615,203 |
2,795,000 |
9.72% |
|
|
| 5 |
FMR LLC |
1,576,666 |
2,728,000 |
9.49% |
|
|
| 6 |
BVF INC/IL |
1,162,000 |
2,010,000 |
6.99% |
|
|
| 7 |
VANGUARD GROUP INC |
603,681 |
1,044,000 |
3.63% |
|
|
| 8 |
Opus Point Partners Management, LLC |
546,467 |
945,000 |
3.29% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
419,362 |
725,000 |
2.52% |
|
|
| 10 |
SSI INVESTMENT MANAGEMENT LLC |
353,190 |
612,000 |
2.13% |
|
|
| 11 |
SPHERA FUNDS MANAGEMENT LTD. |
349,560 |
605,000 |
2.10% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
264,900 |
458,000 |
1.59% |
|
|
| 13 |
Weiss Multi-Strategy Advisers LLC |
200,000 |
346,000 |
1.20% |
|
|
| 14 |
HARBOURVEST PARTNERS LLC |
107,604 |
186,000 |
0.65% |
|
|
| 15 |
Spark Investment Management LLC |
106,100 |
180,000 |
0.63% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
90,232 |
155,000 |
0.54% |
|
|
| 17 |
MORGAN STANLEY |
77,788 |
135,000 |
0.47% |
|
|
| 18 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
76,884 |
133,000 |
0.46% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
76,360 |
132,000 |
0.46% |
|
|
| 20 |
BLAIR WILLIAM & CO/IL |
70,635 |
122,000 |
0.42% |
|
|
| 21 |
BlackRock Fund Advisors |
62,043 |
107,000 |
0.37% |
|
|
| 22 |
Old West Investment Management, LLC |
61,089 |
105,000 |
0.37% |
|
|
| 23 |
GLENMEDE TRUST CO NA |
56,716 |
98,000 |
0.34% |
|
|
| 24 |
Nationwide Fund Advisors |
52,000 |
90,000 |
0.31% |
|
|
| 25 |
NORTHERN TRUST CORP |
40,670 |
70,000 |
0.24% |
|
|
| 26 |
PNC FINANCIAL SERVICES GROUP, INC. |
35,000 |
60,000 |
0.21% |
|
|
| 27 |
Virtu KCG Holdings LLC |
29,770 |
52,000 |
0.18% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
86,700 |
36,000 |
0.13% |
|
|
| 29 |
VALLEY WEALTH MANAGERS, INC. |
15,861 |
27,000 |
0.09% |
|
|
| 30 |
GOLDMAN SACHS GROUP INC |
13,613 |
24,000 |
0.08% |
|
|
| 31 |
D. E. Shaw & Co., Inc. |
11,725 |
20,000 |
0.07% |
|
|
| 32 |
DIMENSIONAL FUND ADVISORS LP |
5,656 |
10,000 |
0.03% |
|
|
| 33 |
BlackRock Investment Management, LLC |
5,103 |
9,000 |
0.03% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
2,698 |
5,000 |
0.02% |
|
|
| 35 |
CITIGROUP INC |
489 |
1,000 |
0.00% |
|
|
| 36 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
229 |
0 |
0.00% |
|
|
