| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 10,539,986 | 162,105,000 | 15.22% | ||
| 2 | VANGUARD GROUP INC | 4,160,274 | 63,985,000 | 6.01% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,884,409 | 59,742,000 | 5.61% | ||
| 4 | FMR LLC | 3,795,700 | 58,378,000 | 5.48% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 3,741,656 | 57,547,000 | 5.40% | ||
| 6 | Camber Capital Management LP | 3,000,000 | 46,140,000 | 4.33% | ||
| 7 | FRANKLIN RESOURCES INC | 2,946,900 | 45,323,000 | 4.26% | ||
| 8 | STATE STREET CORP | 2,631,452 | 40,469,000 | 3.80% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,554,011 | 39,281,000 | 3.69% | ||
| 10 | OAK RIDGE INVESTMENTS LLC | 2,081,792 | 32,012,000 | 3.01% | ||
| 11 | BlackRock Fund Advisors | 2,047,374 | 31,489,000 | 2.96% | ||
| 12 | EAGLE ASSET MANAGEMENT INC | 1,562,270 | 24,027,000 | 2.26% | ||
| 13 | Allianz Asset Management GmbH | 1,491,020 | 22,931,000 | 2.15% | ||
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,277,096 | 19,642,000 | 1.84% | ||
| 15 | Point72 Asset Management, L.P. | 1,247,000 | 19,179,000 | 1.80% | ||
| 16 | Apex Capital Management | 1,119,172 | 17,213,000 | 1.62% | ||
| 17 | JPMORGAN CHASE & CO | 1,108,206 | 17,043,000 | 1.60% | ||
| 18 | NORTHERN TRUST CORP | 1,043,831 | 16,054,000 | 1.51% | ||
| 19 | Invesco Ltd. | 948,182 | 14,583,000 | 1.37% | ||
| 20 | HARVEY CAPITAL MANAGEMENT INC | 932,400 | 14,340,000 | 1.35% | ||
| 21 | NORTHPOINTE CAPITAL LLC | 892,011 | 13,719,000 | 1.29% | ||
| 22 | OppenheimerFunds, Inc. | 847,405 | 13,033,000 | 1.22% | ||
| 23 | STIFEL FINANCIAL CORP | 791,982 | 12,181,000 | 1.14% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 719,100 | 11,059,000 | 1.04% | Call | |
| 25 | VHCP Management, LLC | 700,273 | 10,770,000 | 1.01% | ||
| 26 | JANUS HENDERSON INVESTORS US LLC | 676,690 | 10,407,000 | 0.98% | ||
| 27 | AMERIPRISE FINANCIAL INC | 675,588 | 10,392,000 | 0.98% | ||
| 28 | QVT Financial LP | 626,200 | 9,631,000 | 0.90% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 599,900 | 9,226,000 | 0.87% | Put | |
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 518,057 | 7,967,000 | 0.75% | ||
| 31 | Bank of New York Mellon Corp | 512,770 | 7,886,000 | 0.74% | ||
| 32 | OXFORD ASSET MANAGEMENT LLP | 451,190 | 6,952,000 | 0.65% | ||
| 33 | MANAGED ACCOUNT ADVISORS LLC | 437,405 | 6,728,000 | 0.63% | ||
| 34 | LORD, ABBETT & CO. LLC | 391,277 | 6,018,000 | 0.57% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 348,796 | 5,364,000 | 0.50% | ||
| 36 | CITY NATIONAL BANK | 314,287 | 4,834,000 | 0.45% | ||
| 37 | BlackRock Investment Management, LLC | 250,130 | 3,847,000 | 0.36% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 248,635 | 3,824,000 | 0.36% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 245,776 | 3,780,000 | 0.35% | ||
| 40 | Clearbridge Investments, LLC | 242,737 | 3,733,000 | 0.35% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 240,361 | 3,697,000 | 0.35% | ||
| 42 | Rhenman & Partners Asset Management AB | 240,000 | 3,691,000 | 0.35% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 229,598 | 3,532,000 | 0.33% | ||
| 44 | MORGAN STANLEY | 225,860 | 3,473,000 | 0.33% | ||
| 45 | GROUP ONE TRADING LLC | 223,879 | 3,443,000 | 0.32% | ||
| 46 | PICTET ASSET MANAGEMENT LTD | 218,000 | 3,353,000 | 0.31% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 202,600 | 3,116,000 | 0.29% | ||
| 48 | Knoll Capital Management, LLC | 200,000 | 3,076,000 | 0.29% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 182,300 | 2,804,000 | 0.26% | ||
| 50 | Informed Momentum Co LLC | 168,513 | 2,592,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
