| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAUPOST GROUP LLC/MA | 18,300,000 | 258,945,000 | 23.20% | ||
| 2 | VANGUARD GROUP INC | 5,690,238 | 80,517,000 | 7.21% | ||
| 3 | FRANKLIN RESOURCES INC | 5,344,500 | 75,625,000 | 6.78% | ||
| 4 | FMR LLC | 4,000,792 | 56,612,000 | 5.07% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 3,257,358 | 46,092,000 | 4.13% | ||
| 6 | OAK RIDGE INVESTMENTS LLC | 3,247,990 | 45,959,000 | 4.12% | ||
| 7 | Camber Capital Management LP | 3,000,000 | 42,450,000 | 3.80% | ||
| 8 | STATE STREET CORP | 2,653,395 | 37,549,000 | 3.36% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,419,339 | 34,234,000 | 3.07% | ||
| 10 | BlackRock Fund Advisors | 2,333,888 | 33,025,000 | 2.96% | ||
| 11 | EAGLE ASSET MANAGEMENT INC | 2,191,461 | 31,009,000 | 2.78% | ||
| 12 | Apex Capital Management | 1,843,754 | 26,089,000 | 2.34% | ||
| 13 | JPMORGAN CHASE & CO | 1,650,452 | 23,353,000 | 2.09% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,183,484 | 16,746,000 | 1.50% | ||
| 15 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,053,396 | 14,906,000 | 1.34% | ||
| 16 | NORTHERN TRUST CORP | 1,007,373 | 14,254,000 | 1.28% | ||
| 17 | Cormorant Asset Management, LP | 1,000,000 | 14,150,000 | 1.27% | ||
| 18 | OppenheimerFunds, Inc. | 950,192 | 13,445,000 | 1.20% | ||
| 19 | Invesco Ltd. | 948,182 | 13,416,000 | 1.20% | ||
| 20 | C WorldWide Group Holding A/S | 805,502 | 11,398,000 | 1.02% | ||
| 21 | Bank of New York Mellon Corp | 774,675 | 10,962,000 | 0.98% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 636,900 | 9,012,000 | 0.81% | Put | |
| 23 | EcoR1 Capital, LLC | 589,000 | 8,334,000 | 0.75% | Call | |
| 24 | MANAGED ACCOUNT ADVISORS LLC | 573,818 | 8,120,000 | 0.73% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 532,270 | 7,531,000 | 0.67% | ||
| 26 | NORTHPOINTE CAPITAL LLC | 514,445 | 7,279,000 | 0.65% | ||
| 27 | PointState Capital LP | 500,000 | 7,075,000 | 0.63% | ||
| 28 | AMERIPRISE FINANCIAL INC | 473,264 | 6,697,000 | 0.60% | ||
| 29 | PICTET ASSET MANAGEMENT LTD | 451,565 | 6,390,000 | 0.57% | ||
| 30 | VICTORY CAPITAL MANAGEMENT INC | 419,575 | 5,937,000 | 0.53% | ||
| 31 | Candriam S.C.A. | 390,000 | 5,519,000 | 0.49% | ||
| 32 | CITY NATIONAL BANK | 350,514 | 4,959,000 | 0.44% | ||
| 33 | Allianz Asset Management GmbH | 330,892 | 4,682,000 | 0.42% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 319,265 | 4,518,000 | 0.40% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 313,500 | 4,436,000 | 0.40% | Call | |
| 36 | 1832 Asset Management L.P. | 311,500 | 4,403,000 | 0.39% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 280,804 | 3,973,000 | 0.36% | ||
| 38 | MORGAN STANLEY | 272,685 | 3,859,000 | 0.35% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 259,948 | 3,679,000 | 0.33% | ||
| 40 | BlackRock Investment Management, LLC | 248,814 | 3,521,000 | 0.32% | ||
| 41 | HIGHLAND CAPITAL MANAGEMENT LP | 237,822 | 3,365,000 | 0.30% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 230,317 | 3,259,000 | 0.29% | ||
| 43 | BNP Paribas Asset Management Holding S.A. | 226,252 | 3,201,000 | 0.29% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 239,800 | 3,134,000 | 0.28% | ||
| 45 | DEUTSCHE BANK AG\ | 221,387 | 3,129,000 | 0.28% | ||
| 46 | Nantahala Capital Management, LLC | 209,000 | 2,957,000 | 0.26% | Put | |
| 47 | PERCEPTIVE ADVISORS LLC | 200,000 | 2,830,000 | 0.25% | Put | |
| 48 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 2,830,000 | 0.25% | ||
| 49 | Knoll Capital Management, LLC | 200,000 | 2,830,000 | 0.25% | ||
| 50 | HealthCor Management, L.P. | 178,300 | 2,523,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
