| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,261,561 | 49,491,000 | 16.89% | ||
| 2 | PFM Health Sciences, LP | 729,044 | 28,600,000 | 9.76% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 618,071 | 24,247,000 | 8.28% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 564,483 | 22,145,000 | 7.56% | ||
| 5 | Novo Holdings A/S | 506,730 | 19,879,000 | 6.78% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 493,910 | 19,376,000 | 6.61% | ||
| 7 | Redmile Group, LLC | 474,132 | 18,600,000 | 6.35% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 391,800 | 15,370,000 | 5.25% | ||
| 9 | VANGUARD GROUP INC | 329,223 | 12,915,000 | 4.41% | ||
| 10 | BlackRock Fund Advisors | 151,940 | 5,961,000 | 2.03% | ||
| 11 | EMERALD ADVISERS, LLC | 150,281 | 5,896,000 | 2.01% | ||
| 12 | WALL STREET ASSOCIATES | 143,400 | 5,626,000 | 1.92% | ||
| 13 | EMERALD MUTUAL FUND ADVISERS TRUST | 136,204 | 5,343,000 | 1.82% | ||
| 14 | Asset Management One Co., Ltd. | 101,461 | 3,990,000 | 1.36% | ||
| 15 | VHCP Management, LLC | 100,000 | 3,923,000 | 1.34% | ||
| 16 | JENNISON ASSOCIATES LLC | 97,292 | 3,817,000 | 1.30% | ||
| 17 | Rock Springs Capital Management LP | 92,000 | 3,609,000 | 1.23% | ||
| 18 | Ghost Tree Capital, LLC | 85,000 | 3,335,000 | 1.14% | ||
| 19 | JPMORGAN CHASE & CO | 73,975 | 2,902,000 | 0.99% | ||
| 20 | WADDELL & REED FINANCIAL INC | 62,120 | 2,437,000 | 0.83% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 56,253 | 2,207,000 | 0.75% | ||
| 22 | STATE STREET CORP | 56,200 | 2,206,000 | 0.75% | ||
| 23 | Visium Asset Management, LP | 55,011 | 2,158,000 | 0.74% | ||
| 24 | Bank of New York Mellon Corp | 51,484 | 2,019,000 | 0.69% | ||
| 25 | Cormorant Asset Management, LP | 50,000 | 1,962,000 | 0.67% | ||
| 26 | MORGAN STANLEY | 49,817 | 1,953,000 | 0.67% | ||
| 27 | Nicholas Investment Partners, LP | 47,054 | 1,846,000 | 0.63% | ||
| 28 | HIGHLAND CAPITAL MANAGEMENT LP | 37,134 | 1,457,000 | 0.50% | ||
| 29 | Informed Momentum Co LLC | 33,409 | 1,311,000 | 0.45% | ||
| 30 | MAZAMA CAPITAL MANAGEMENT INC | 31,830 | 1,249,000 | 0.43% | ||
| 31 | Atika Capital Management LLC | 31,000 | 1,216,000 | 0.42% | ||
| 32 | AMERIPRISE FINANCIAL INC | 26,734 | 1,049,000 | 0.36% | ||
| 33 | UBS AG | 26,467 | 1,038,000 | 0.35% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 24,948 | 978,000 | 0.33% | ||
| 35 | Alyeska Investment Group, L.P. | 23,930 | 939,000 | 0.32% | ||
| 36 | PANAGORA ASSET MANAGEMENT INC | 23,264 | 913,000 | 0.31% | ||
| 37 | RUSSELL FRANK CO/ | 21,764 | 854,000 | 0.29% | ||
| 38 | PUTNAM INVESTMENTS LLC | 21,335 | 837,000 | 0.29% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,889 | 819,000 | 0.28% | ||
| 40 | GILDER GAGNON HOWE & CO LLC | 20,873 | 819,000 | 0.28% | ||
| 41 | SPHERA FUNDS MANAGEMENT LTD. | 20,682 | 811,000 | 0.28% | ||
| 42 | BlackRock Investment Management, LLC | 18,507 | 726,000 | 0.25% | ||
| 43 | Spark Investment Management LLC | 18,400 | 718,000 | 0.25% | ||
| 44 | Partner Investment Management, L.P. | 16,708 | 655,000 | 0.22% | ||
| 45 | NORTHERN TRUST CORP | 15,246 | 598,000 | 0.20% | ||
| 46 | CITADEL ADVISORS LLC | 14,120 | 554,000 | 0.19% | ||
| 47 | ROYAL BANK OF CANADA | 13,200 | 518,000 | 0.18% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,600 | 494,000 | 0.17% | ||
| 49 | Quantitative Systematic Strategies LLC | 9,047 | 357,000 | 0.12% | ||
| 50 | TEACHERS ADVISORS, LLC | 8,709 | 342,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
