| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,748,920 | 196,406,000 | 19.56% | ||
| 2 | Devon Park Associates, LLC | 2,576,723 | 134,995,000 | 13.45% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,354,558 | 70,965,000 | 7.07% | ||
| 4 | VANGUARD GROUP INC | 965,989 | 50,608,000 | 5.04% | ||
| 5 | SCOPIA CAPITAL MANAGEMENT LP | 924,804 | 48,450,000 | 4.83% | ||
| 6 | STATE STREET CORP | 839,124 | 43,962,000 | 4.38% | ||
| 7 | BlackRock Fund Advisors | 753,828 | 39,493,000 | 3.93% | ||
| 8 | USS Investment Management Ltd | 590,396 | 30,931,000 | 3.08% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 538,618 | 28,218,000 | 2.81% | ||
| 10 | Brandywine Global Investment Management, LLC | 486,906 | 25,510,000 | 2.54% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 465,839 | 24,405,000 | 2.43% | ||
| 12 | PFM Health Sciences, LP | 451,071 | 23,632,000 | 2.35% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 361,777 | 18,953,000 | 1.89% | ||
| 14 | BARCLAYS PLC | 329,100 | 17,113,000 | 1.70% | Call | |
| 15 | Redmile Group, LLC | 302,988 | 15,874,000 | 1.58% | ||
| 16 | LOOMIS SAYLES & CO L P | 291,210 | 15,257,000 | 1.52% | ||
| 17 | Bank of New York Mellon Corp | 274,663 | 14,390,000 | 1.43% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 269,274 | 14,107,000 | 1.41% | ||
| 19 | WADDELL & REED FINANCIAL INC | 205,990 | 10,792,000 | 1.07% | ||
| 20 | CITADEL ADVISORS LLC | 201,002 | 10,531,000 | 1.05% | ||
| 21 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 195,860 | 10,261,000 | 1.02% | ||
| 22 | EMERALD ADVISERS, LLC | 182,877 | 9,581,000 | 0.95% | ||
| 23 | Rock Springs Capital Management LP | 159,000 | 8,330,000 | 0.83% | ||
| 24 | EMERALD MUTUAL FUND ADVISERS TRUST | 134,954 | 7,070,000 | 0.70% | ||
| 25 | DEERFIELD MANAGEMENT COMPANY, L.P. | 132,000 | 6,915,000 | 0.69% | ||
| 26 | WALL STREET ASSOCIATES | 130,700 | 6,847,000 | 0.68% | ||
| 27 | NORTHERN TRUST CORP | 103,586 | 5,427,000 | 0.54% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 102,226 | 5,355,000 | 0.53% | ||
| 29 | VHCP Management, LLC | 100,000 | 5,239,000 | 0.52% | ||
| 30 | RENAISSANCE TECHNOLOGIES LLC | 99,334 | 5,204,000 | 0.52% | ||
| 31 | JENNISON ASSOCIATES LLC | 98,479 | 5,159,000 | 0.51% | ||
| 32 | Opaleye Management Inc. | 95,000 | 4,977,000 | 0.50% | ||
| 33 | LAZARD ASSET MANAGEMENT LLC | 91,575 | 4,797,000 | 0.48% | ||
| 34 | MAZAMA CAPITAL MANAGEMENT INC | 88,943 | 4,660,000 | 0.46% | ||
| 35 | DAFNA Capital Management LLC | 67,100 | 3,515,000 | 0.35% | ||
| 36 | BlackRock Investment Management, LLC | 61,847 | 3,240,000 | 0.32% | ||
| 37 | DEUTSCHE BANK AG\ | 59,703 | 3,126,000 | 0.31% | ||
| 38 | Alyeska Investment Group, L.P. | 56,130 | 2,941,000 | 0.29% | ||
| 39 | RUSSELL FRANK CO/ | 49,800 | 2,609,000 | 0.26% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 49,336 | 2,585,000 | 0.26% | ||
| 41 | PICTET ASSET MANAGEMENT LTD | 42,000 | 2,509,000 | 0.25% | ||
| 42 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 47,400 | 2,483,000 | 0.25% | ||
| 43 | Nicholas Investment Partners, LP | 45,300 | 2,373,000 | 0.24% | ||
| 44 | TWO SIGMA INVESTMENTS, LP | 44,645 | 2,339,000 | 0.23% | ||
| 45 | JPMORGAN CHASE & CO | 43,858 | 2,298,000 | 0.23% | ||
| 46 | PEAK6 Group LLC | 43,000 | 2,253,000 | 0.22% | Call | |
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 38,936 | 2,040,000 | 0.20% | ||
| 48 | WELLS FARGO & COMPANY/MN | 38,023 | 1,992,000 | 0.20% | ||
| 49 | CREDIT SUISSE AG/ | 36,462 | 1,909,000 | 0.19% | ||
| 50 | TD ASSET MANAGEMENT INC | 35,100 | 1,839,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
