| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,737,602 | 157,278,000 | 22.10% | ||
| 2 | Devon Park Associates, LLC | 2,576,723 | 108,429,000 | 15.24% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,360,578 | 57,253,000 | 8.05% | ||
| 4 | SCOPIA CAPITAL MANAGEMENT LP | 974,486 | 41,006,000 | 5.76% | ||
| 5 | PFM Health Sciences, LP | 884,575 | 37,223,000 | 5.23% | ||
| 6 | VANGUARD GROUP INC | 834,585 | 35,119,000 | 4.93% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 659,089 | 27,734,000 | 3.90% | ||
| 8 | RA CAPITAL MANAGEMENT, L.P. | 564,483 | 23,753,000 | 3.34% | ||
| 9 | BlackRock Fund Advisors | 437,054 | 18,391,000 | 2.58% | ||
| 10 | Redmile Group, LLC | 405,688 | 17,071,000 | 2.40% | ||
| 11 | LOOMIS SAYLES & CO L P | 243,315 | 10,239,000 | 1.44% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 219,303 | 9,228,000 | 1.30% | ||
| 13 | Bank of New York Mellon Corp | 213,868 | 8,999,000 | 1.26% | ||
| 14 | WADDELL & REED FINANCIAL INC | 208,290 | 8,765,000 | 1.23% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 186,777 | 7,860,000 | 1.10% | ||
| 16 | EMERALD ADVISERS, LLC | 181,122 | 7,247,000 | 1.02% | ||
| 17 | Ghost Tree Capital, LLC | 165,000 | 6,943,000 | 0.98% | ||
| 18 | Rock Springs Capital Management LP | 158,000 | 6,649,000 | 0.93% | ||
| 19 | Alyeska Investment Group, L.P. | 151,507 | 6,375,000 | 0.90% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 147,385 | 6,202,000 | 0.87% | ||
| 21 | EMERALD MUTUAL FUND ADVISERS TRUST | 152,754 | 6,112,000 | 0.86% | ||
| 22 | WALL STREET ASSOCIATES | 135,700 | 5,710,000 | 0.80% | ||
| 23 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 124,569 | 5,242,000 | 0.74% | ||
| 24 | Asset Management One Co., Ltd. | 102,022 | 4,340,000 | 0.61% | ||
| 25 | VHCP Management, LLC | 100,000 | 4,208,000 | 0.59% | ||
| 26 | JENNISON ASSOCIATES LLC | 97,496 | 4,103,000 | 0.58% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 92,451 | 3,890,000 | 0.55% | ||
| 28 | STATE STREET CORP | 90,584 | 3,809,000 | 0.54% | ||
| 29 | LAZARD ASSET MANAGEMENT LLC | 89,175 | 3,752,000 | 0.53% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 88,476 | 3,723,000 | 0.52% | ||
| 31 | CITADEL ADVISORS LLC | 86,148 | 3,625,000 | 0.51% | ||
| 32 | Nicholas Investment Partners, LP | 84,743 | 3,566,000 | 0.50% | ||
| 33 | Laurion Capital Management LP | 81,634 | 3,435,000 | 0.48% | ||
| 34 | Opaleye Management Inc. | 75,000 | 3,156,000 | 0.44% | ||
| 35 | AQR ARBITRAGE LLC | 75,000 | 3,156,000 | 0.44% | ||
| 36 | RTW INVESTMENTS, LP | 71,315 | 3,001,000 | 0.42% | ||
| 37 | NORTHERN TRUST CORP | 70,583 | 2,970,000 | 0.42% | ||
| 38 | Informed Momentum Co LLC | 70,251 | 2,956,000 | 0.42% | ||
| 39 | MAZAMA CAPITAL MANAGEMENT INC | 64,089 | 2,697,000 | 0.38% | ||
| 40 | MONASHEE INVESTMENT MANAGEMENT LLC | 60,000 | 2,525,000 | 0.35% | ||
| 41 | JPMORGAN CHASE & CO | 58,733 | 2,472,000 | 0.35% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 40,410 | 1,700,000 | 0.24% | ||
| 43 | DAFNA Capital Management LLC | 39,100 | 1,645,000 | 0.23% | ||
| 44 | DRIEHAUS CAPITAL MANAGEMENT LLC | 38,021 | 1,600,000 | 0.22% | ||
| 45 | TD ASSET MANAGEMENT INC | 37,300 | 1,570,000 | 0.22% | ||
| 46 | UBS Group AG | 36,914 | 1,553,000 | 0.22% | ||
| 47 | WELLS FARGO & COMPANY/MN | 36,484 | 1,536,000 | 0.22% | ||
| 48 | PICTET ASSET MANAGEMENT LTD | 37,800 | 1,439,000 | 0.20% | ||
| 49 | CREDIT SUISSE AG/ | 32,662 | 1,375,000 | 0.19% | ||
| 50 | Quantitative Systematic Strategies LLC | 31,593 | 1,344,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
