| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 6,372,923 | 51,621,000 | 24.72% | ||
| 2 | FMR LLC | 4,980,794 | 40,344,000 | 19.32% | ||
| 3 | HIGHLAND CAPITAL MANAGEMENT LP | 2,440,521 | 19,768,000 | 9.47% | ||
| 4 | Cormorant Asset Management, LP | 2,307,903 | 18,694,000 | 8.95% | ||
| 5 | BlackRock Finance, Inc. | 1,518,325 | 12,298,000 | 5.89% | ||
| 6 | VANGUARD GROUP INC | 939,297 | 7,608,000 | 3.64% | ||
| 7 | FRANKLIN RESOURCES INC | 833,100 | 6,748,000 | 3.23% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 810,537 | 6,565,000 | 3.14% | ||
| 9 | NEXTHERA CAPITAL LP | 757,200 | 6,133,000 | 2.94% | ||
| 10 | ORBIMED ADVISORS LLC | 704,300 | 5,705,000 | 2.73% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 609,344 | 4,936,000 | 2.36% | ||
| 12 | MARSHALL WACE NORTH AMERICA, L.P. | 432,171 | 3,457,000 | 1.66% | ||
| 13 | MARSHALL WACE ASIA LTD | 432,171 | 3,457,000 | 1.66% | ||
| 14 | STATE STREET CORP | 299,947 | 2,429,000 | 1.16% | ||
| 15 | Artal Group S.A. | 251,300 | 2,036,000 | 0.98% | ||
| 16 | NORTHERN TRUST CORP | 233,451 | 1,891,000 | 0.91% | ||
| 17 | PNC FINANCIAL SERVICES GROUP, INC. | 205,083 | 1,660,000 | 0.80% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 137,443 | 1,113,000 | 0.53% | ||
| 19 | DAFNA Capital Management LLC | 101,317 | 821,000 | 0.39% | ||
| 20 | Iguana Healthcare Management, LLC | 100,000 | 810,000 | 0.39% | ||
| 21 | HANDELSBANKEN FONDER AB | 95,000 | 770,000 | 0.37% | ||
| 22 | Bank of New York Mellon Corp | 80,201 | 649,000 | 0.31% | ||
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 80,000 | 648,000 | 0.31% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 75,661 | 613,000 | 0.29% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 69,700 | 565,000 | 0.27% | ||
| 26 | ALLIANCEBERNSTEIN L.P. | 56,200 | 455,000 | 0.22% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,673 | 402,000 | 0.19% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,437 | 336,000 | 0.16% | ||
| 29 | Swiss National Bank | 40,003 | 324,000 | 0.16% | ||
| 30 | GSA CAPITAL PARTNERS LLP | 39,600 | 321,000 | 0.15% | ||
| 31 | GOLDMAN SACHS GROUP INC | 37,901 | 307,000 | 0.15% | ||
| 32 | JPMORGAN CHASE & CO | 34,854 | 282,000 | 0.14% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 34,600 | 281,000 | 0.13% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 34,427 | 279,000 | 0.13% | ||
| 35 | MORGAN STANLEY | 33,561 | 272,000 | 0.13% | ||
| 36 | J. Goldman & Co LP | 33,200 | 269,000 | 0.13% | ||
| 37 | TEACHERS ADVISORS, LLC | 31,226 | 253,000 | 0.12% | ||
| 38 | ALPS ADVISORS INC | 29,944 | 243,000 | 0.12% | ||
| 39 | ClariVest Asset Management LLC | 29,200 | 236,000 | 0.11% | ||
| 40 | JACOBS LEVY EQUITY MANAGEMENT, INC | 28,500 | 231,000 | 0.11% | ||
| 41 | TD ASSET MANAGEMENT INC | 27,100 | 220,000 | 0.11% | ||
| 42 | D. E. Shaw & Co., Inc. | 26,139 | 212,000 | 0.10% | ||
| 43 | DEUTSCHE BANK AG\ | 23,713 | 191,000 | 0.09% | ||
| 44 | VIRTUS ETF ADVISERS LLC | 20,809 | 169,000 | 0.08% | ||
| 45 | ProShare Advisors LLC | 20,766 | 168,000 | 0.08% | ||
| 46 | RHUMBLINE ADVISERS | 19,932 | 161,000 | 0.08% | ||
| 47 | CREDIT SUISSE AG/ | 18,327 | 149,000 | 0.07% | ||
| 48 | SECOR Capital Advisors, LP | 18,031 | 146,000 | 0.07% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 17,301 | 140,000 | 0.07% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,108 | 130,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
