| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 6,058,642 | 61,859,000 | 27.50% | ||
| 2 | FMR LLC | 4,980,794 | 50,854,000 | 22.60% | ||
| 3 | Cormorant Asset Management, LP | 2,800,000 | 28,588,000 | 12.71% | ||
| 4 | HIGHLAND CAPITAL MANAGEMENT LP | 868,333 | 8,866,000 | 3.94% | ||
| 5 | FRANKLIN RESOURCES INC | 850,000 | 8,679,000 | 3.86% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 830,586 | 8,480,000 | 3.77% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 810,537 | 8,275,000 | 3.68% | ||
| 8 | VANGUARD GROUP INC | 604,570 | 6,173,000 | 2.74% | ||
| 9 | BAKER BROS. ADVISORS LP | 508,405 | 5,191,000 | 2.31% | ||
| 10 | BlackRock Fund Advisors | 413,604 | 4,223,000 | 1.88% | ||
| 11 | ORBIMED ADVISORS LLC | 321,500 | 3,283,000 | 1.46% | ||
| 12 | MARSHALL WACE, LLP | 261,505 | 2,670,000 | 1.19% | ||
| 13 | STATE STREET CORP | 243,476 | 2,484,000 | 1.10% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 201,600 | 2,058,000 | 0.91% | ||
| 15 | VIVO CAPITAL, LLC | 200,000 | 2,042,000 | 0.91% | ||
| 16 | Informed Momentum Co LLC | 197,025 | 2,012,000 | 0.89% | ||
| 17 | NORTHERN TRUST CORP | 178,509 | 1,823,000 | 0.81% | ||
| 18 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 170,697 | 1,743,000 | 0.77% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 134,055 | 1,369,000 | 0.61% | ||
| 20 | Iguana Healthcare Management, LLC | 125,000 | 1,276,000 | 0.57% | ||
| 21 | NEXTHERA CAPITAL LP | 107,000 | 1,092,000 | 0.49% | ||
| 22 | J. Goldman & Co LP | 100,938 | 1,031,000 | 0.46% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 99,728 | 1,018,000 | 0.45% | ||
| 24 | DAFNA Capital Management LLC | 80,100 | 818,000 | 0.36% | ||
| 25 | EMERALD ACQUISITION LTD. | 62,911 | 642,000 | 0.29% | ||
| 26 | BlackRock Investment Management, LLC | 61,707 | 630,000 | 0.28% | ||
| 27 | ALLIANCEBERNSTEIN L.P. | 58,500 | 597,000 | 0.27% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,221 | 533,000 | 0.24% | ||
| 29 | Bank of New York Mellon Corp | 51,128 | 523,000 | 0.23% | ||
| 30 | HANDELSBANKEN FONDER AB | 50,000 | 510,000 | 0.23% | ||
| 31 | D. E. Shaw & Co., Inc. | 48,790 | 498,000 | 0.22% | ||
| 32 | MONASHEE INVESTMENT MANAGEMENT LLC | 43,000 | 439,000 | 0.20% | PRN | |
| 33 | SABBY MANAGEMENT, LLC | 38,000 | 388,000 | 0.17% | ||
| 34 | JACOBS LEVY EQUITY MANAGEMENT, INC | 37,357 | 381,000 | 0.17% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,537 | 342,000 | 0.15% | ||
| 36 | ClariVest Asset Management LLC | 26,100 | 266,000 | 0.12% | ||
| 37 | TEACHERS ADVISORS, LLC | 25,964 | 265,000 | 0.12% | ||
| 38 | VIRTUS ETF ADVISERS LLC | 25,630 | 262,000 | 0.12% | ||
| 39 | M&T BANK CORP | 25,465 | 260,000 | 0.12% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,000 | 256,000 | 0.11% | ||
| 41 | TUDOR INVESTMENT CORP ET AL | 22,500 | 230,000 | 0.10% | ||
| 42 | MORGAN STANLEY | 20,316 | 208,000 | 0.09% | ||
| 43 | Visium Asset Management, LP | 19,856 | 203,000 | 0.09% | ||
| 44 | SUMMIT SECURITIES GROUP LLC | 17,483 | 179,000 | 0.08% | ||
| 45 | RHUMBLINE ADVISERS | 15,638 | 160,000 | 0.07% | ||
| 46 | BANK OF MONTREAL /CAN/ | 15,300 | 156,000 | 0.07% | ||
| 47 | Sterling Capital Management LLC | 13,613 | 139,000 | 0.06% | ||
| 48 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 13,489 | 138,000 | 0.06% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,538 | 128,000 | 0.06% | ||
| 50 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 10,502 | 107,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
