| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 6,358,642 | 74,714,000 | 25.73% | ||
| 2 | FMR LLC | 4,980,794 | 58,524,000 | 20.15% | ||
| 3 | Cormorant Asset Management, LP | 2,652,436 | 31,166,000 | 10.73% | ||
| 4 | HIGHLAND CAPITAL MANAGEMENT LP | 1,141,333 | 13,411,000 | 4.62% | ||
| 5 | BlackRock Fund Advisors | 1,091,730 | 12,828,000 | 4.42% | ||
| 6 | FRANKLIN RESOURCES INC | 833,100 | 9,789,000 | 3.37% | ||
| 7 | VANGUARD GROUP INC | 828,421 | 9,735,000 | 3.35% | ||
| 8 | PERCEPTIVE ADVISORS LLC | 810,537 | 9,523,000 | 3.28% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 600,952 | 7,061,000 | 2.43% | ||
| 10 | ORBIMED ADVISORS LLC | 556,200 | 6,535,000 | 2.25% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 536,097 | 6,299,000 | 2.17% | ||
| 12 | NEXTHERA CAPITAL LP | 492,958 | 5,792,000 | 1.99% | ||
| 13 | MARSHALL WACE, LLP | 442,820 | 5,203,000 | 1.79% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 302,650 | 3,556,000 | 1.22% | ||
| 15 | STATE STREET CORP | 275,144 | 3,231,000 | 1.11% | ||
| 16 | BAKER BROS. ADVISORS LP | 258,805 | 3,041,000 | 1.05% | ||
| 17 | Artal Group S.A. | 251,300 | 2,953,000 | 1.02% | ||
| 18 | NORTHERN TRUST CORP | 237,220 | 2,787,000 | 0.96% | ||
| 19 | Iguana Healthcare Management, LLC | 150,000 | 1,763,000 | 0.61% | ||
| 20 | Informed Momentum Co LLC | 137,685 | 1,618,000 | 0.56% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 127,433 | 1,497,000 | 0.52% | ||
| 22 | Invesco Ltd. | 122,640 | 1,441,000 | 0.50% | ||
| 23 | J. Goldman & Co LP | 103,281 | 1,214,000 | 0.42% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 80,000 | 940,000 | 0.32% | ||
| 25 | Bank of New York Mellon Corp | 78,915 | 927,000 | 0.32% | ||
| 26 | BlackRock Investment Management, LLC | 74,701 | 878,000 | 0.30% | ||
| 27 | MORGAN STANLEY | 72,675 | 854,000 | 0.29% | ||
| 28 | NORGES BANK | 71,428 | 839,000 | 0.29% | ||
| 29 | HANDELSBANKEN FONDER AB | 70,000 | 822,000 | 0.28% | ||
| 30 | ALLIANCEBERNSTEIN L.P. | 58,500 | 687,000 | 0.24% | ||
| 31 | RUSSELL INVESTMENTS GROUP, LTD. | 51,967 | 619,000 | 0.21% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 51,474 | 605,000 | 0.21% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,705 | 596,000 | 0.21% | ||
| 34 | JPMORGAN CHASE & CO | 49,976 | 587,000 | 0.20% | ||
| 35 | GOLDMAN SACHS GROUP INC | 49,133 | 577,000 | 0.20% | ||
| 36 | Swiss National Bank | 40,003 | 470,000 | 0.16% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,137 | 460,000 | 0.16% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 34,600 | 407,000 | 0.14% | ||
| 39 | AQR CAPITAL MANAGEMENT LLC | 34,521 | 406,000 | 0.14% | ||
| 40 | ALPS ADVISORS INC | 33,448 | 393,000 | 0.14% | ||
| 41 | CREDIT SUISSE AG/ | 30,522 | 359,000 | 0.12% | ||
| 42 | TEACHERS ADVISORS, LLC | 29,085 | 342,000 | 0.12% | ||
| 43 | ClariVest Asset Management LLC | 28,900 | 339,000 | 0.12% | ||
| 44 | JACOBS LEVY EQUITY MANAGEMENT, INC | 28,500 | 335,000 | 0.12% | ||
| 45 | TD ASSET MANAGEMENT INC | 26,743 | 314,000 | 0.11% | ||
| 46 | ProShare Advisors LLC | 26,048 | 306,000 | 0.11% | ||
| 47 | M&T BANK CORP | 24,617 | 289,000 | 0.10% | ||
| 48 | RHUMBLINE ADVISERS | 19,140 | 225,000 | 0.08% | ||
| 49 | VIRTUS ETF ADVISERS LLC | 18,814 | 221,000 | 0.08% | ||
| 50 | OXFORD ASSET MANAGEMENT LLP | 18,578 | 218,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
