| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,411,661 | 203,466,000 | 11.53% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,439,653 | 158,637,000 | 8.99% | ||
| 3 | JPMORGAN CHASE & CO | 2,465,923 | 113,876,000 | 6.45% | ||
| 4 | PUTNAM INVESTMENTS LLC | 1,905,612 | 87,887,000 | 4.98% | ||
| 5 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,716,355 | 79,261,000 | 4.49% | ||
| 6 | VANGUARD GROUP INC | 1,593,956 | 73,513,000 | 4.17% | ||
| 7 | LORD, ABBETT & CO. LLC | 1,563,782 | 72,122,000 | 4.09% | ||
| 8 | BlackRock Fund Advisors | 1,122,282 | 51,827,000 | 2.94% | ||
| 9 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,099,200 | 50,695,000 | 2.87% | Put | |
| 10 | EAGLE ASSET MANAGEMENT INC | 1,060,633 | 48,980,000 | 2.78% | ||
| 11 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,013,800 | 46,756,000 | 2.65% | Call | |
| 12 | SECTORAL ASSET MANAGEMENT INC | 934,100 | 43,137,000 | 2.44% | ||
| 13 | PointState Capital LP | 925,000 | 42,717,000 | 2.42% | ||
| 14 | STATE STREET CORP | 912,178 | 42,071,000 | 2.38% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 761,212 | 35,153,000 | 1.99% | ||
| 16 | Consonance Capital Management LP | 758,970 | 35,049,000 | 1.99% | ||
| 17 | GOLDMAN SACHS GROUP INC | 636,100 | 29,375,000 | 1.66% | Put | |
| 18 | BAKER BROS. ADVISORS LP | 513,922 | 23,702,000 | 1.34% | ||
| 19 | ADVENT INTERNATIONAL, L.P. | 497,001 | 22,952,000 | 1.30% | ||
| 20 | DEUTSCHE BANK AG\ | 496,190 | 22,911,000 | 1.30% | ||
| 21 | JANUS HENDERSON INVESTORS US LLC | 449,128 | 20,714,000 | 1.17% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 446,977 | 20,642,000 | 1.17% | ||
| 23 | BARCLAYS PLC | 413,600 | 19,026,000 | 1.08% | Put | |
| 24 | NORTHERN TRUST CORP | 400,989 | 18,518,000 | 1.05% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 377,577 | 17,414,000 | 0.99% | ||
| 26 | Alberta Investment Management Corp | 376,510 | 17,365,000 | 0.98% | ||
| 27 | GOLDMAN SACHS GROUP INC | 358,900 | 16,574,000 | 0.94% | Call | |
| 28 | Broadfin Capital, LLC | 350,000 | 16,163,000 | 0.92% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 315,412 | 14,546,000 | 0.82% | ||
| 30 | HealthCor Management, L.P. | 300,000 | 13,854,000 | 0.79% | Call | |
| 31 | BLACKROCK ADVISORS LLC | 293,992 | 13,577,000 | 0.77% | ||
| 32 | BANK OF MONTREAL /CAN/ | 259,710 | 11,993,000 | 0.68% | ||
| 33 | BARCLAYS PLC | 252,307 | 11,606,000 | 0.66% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 211,597 | 9,772,000 | 0.55% | ||
| 35 | CHARTWELL INVESTMENT PARTNERS/PA | 207,870 | 9,599,000 | 0.54% | ||
| 36 | KBC Group NV | 201,208 | 9,292,000 | 0.53% | ||
| 37 | ORBIMED ADVISORS LLC | 200,000 | 9,236,000 | 0.52% | Put | |
| 38 | PRICE MICHAEL F | 200,000 | 9,236,000 | 0.52% | ||
| 39 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 200,000 | 9,236,000 | 0.52% | Call | |
| 40 | ORBIMED ADVISORS LLC | 200,000 | 9,236,000 | 0.52% | Call | |
| 41 | GOLDMAN SACHS GROUP INC | 182,029 | 8,406,000 | 0.48% | ||
| 42 | BARCLAYS PLC | 177,700 | 8,174,000 | 0.46% | Call | |
| 43 | Bank of New York Mellon Corp | 159,092 | 7,347,000 | 0.42% | ||
| 44 | FRED ALGER MANAGEMENT, LLC | 154,579 | 7,138,000 | 0.40% | ||
| 45 | D. E. Shaw & Co., Inc. | 152,500 | 7,034,000 | 0.40% | Put | |
| 46 | CAPITAL FUND MANAGEMENT S.A. | 151,925 | 7,007,000 | 0.40% | ||
| 47 | AXA S.A. | 151,156 | 6,971,000 | 0.39% | ||
| 48 | GEODE CAPITAL MANAGEMENT, LLC | 140,240 | 6,467,000 | 0.37% | ||
| 49 | WADDELL & REED FINANCIAL INC | 130,320 | 6,010,000 | 0.34% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 119,061 | 5,491,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
