| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SCOPIA CAPITAL MANAGEMENT LP | 5,703,587 | 77,569,000 | 18.47% | ||
| 2 | FMR LLC | 4,281,264 | 58,225,000 | 13.86% | ||
| 3 | Sarissa Capital Management LP | 2,555,000 | 34,748,000 | 8.27% | ||
| 4 | Broadfin Capital, LLC | 2,320,366 | 31,557,000 | 7.51% | ||
| 5 | PUTNAM INVESTMENTS LLC | 1,913,600 | 26,025,000 | 6.20% | ||
| 6 | VANGUARD GROUP INC | 1,887,779 | 25,674,000 | 6.11% | ||
| 7 | BlackRock Fund Advisors | 1,510,603 | 20,544,000 | 4.89% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,408,396 | 19,154,000 | 4.56% | ||
| 9 | MORGAN STANLEY | 1,093,114 | 14,866,000 | 3.54% | ||
| 10 | NORTH TIDE CAPITAL, LLC | 919,414 | 12,504,000 | 2.98% | ||
| 11 | Avoro Capital Advisors LLC | 806,300 | 10,966,000 | 2.61% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 753,227 | 10,244,000 | 2.44% | ||
| 13 | CREDIT SUISSE AG/ | 444,316 | 6,043,000 | 1.44% | ||
| 14 | NORTHERN TRUST CORP | 320,878 | 4,364,000 | 1.04% | ||
| 15 | HighVista Strategies LLC | 265,110 | 3,605,000 | 0.86% | ||
| 16 | Ghost Tree Capital, LLC | 250,000 | 3,400,000 | 0.81% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 232,800 | 3,166,000 | 0.75% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 222,700 | 3,029,000 | 0.72% | Call | |
| 19 | Tekla Capital Management LLC | 206,000 | 2,802,000 | 0.67% | ||
| 20 | TFS CAPITAL LLC | 184,947 | 2,515,000 | 0.60% | ||
| 21 | GOLDMAN SACHS GROUP INC | 182,408 | 2,481,000 | 0.59% | ||
| 22 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 175,709 | 2,390,000 | 0.57% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 173,655 | 2,361,000 | 0.56% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 172,143 | 2,341,000 | 0.56% | ||
| 25 | Bank of New York Mellon Corp | 165,921 | 2,258,000 | 0.54% | ||
| 26 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 2,040,000 | 0.49% | ||
| 27 | DEUTSCHE BANK AG\ | 122,163 | 1,660,000 | 0.40% | ||
| 28 | Candriam S.C.A. | 115,800 | 1,575,000 | 0.38% | ||
| 29 | PDT Partners, LLC | 103,286 | 1,405,000 | 0.33% | ||
| 30 | CQS Cayman LP | 100,000 | 1,360,000 | 0.32% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,100 | 1,266,000 | 0.30% | Put | |
| 32 | WOLVERINE ASSET MANAGEMENT LLC | 1,275 | 1,263,000 | 0.30% | Put | |
| 33 | AJO, LP | 91,510 | 1,245,000 | 0.30% | ||
| 34 | BlackRock Investment Management, LLC | 89,331 | 1,215,000 | 0.29% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 81,785 | 1,112,000 | 0.26% | ||
| 36 | RICE HALL JAMES & ASSOCIATES, LLC | 78,804 | 1,072,000 | 0.26% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 77,692 | 1,056,000 | 0.25% | ||
| 38 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 75,100 | 1,021,000 | 0.24% | ||
| 39 | NORGES BANK | 72,473 | 986,000 | 0.23% | ||
| 40 | Connor, Clark & Lunn Investment Management Ltd. | 70,900 | 964,000 | 0.23% | ||
| 41 | Spark Investment Management LLC | 64,800 | 880,000 | 0.21% | ||
| 42 | Freedom Investment Management, Inc. | 32,925 | 866,000 | 0.21% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 59,250 | 806,000 | 0.19% | ||
| 44 | Healthcare Value Capital, LLC | 50,000 | 680,000 | 0.16% | ||
| 45 | GROUP ONE TRADING LLC | 47,325 | 644,000 | 0.15% | ||
| 46 | Birchview Capital, LP | 46,000 | 626,000 | 0.15% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,598 | 620,000 | 0.15% | ||
| 48 | AMERICAFIRST CAPITAL MANAGEMENT, LLC | 45,483 | 618,569 | 0.15% | ||
| 49 | GOLDMAN SACHS GROUP INC | 45,000 | 612,000 | 0.15% | Put | |
| 50 | STRS OHIO | 44,000 | 598,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
