Dark
Light
System
Institutional Investment Manager
SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. (CIK: 0001496201), located at 4 Itzhak Sade Building A, Tel Aviv, L3. Institutional holdings reported to the SEC.

Institutional Holdings (2015Q3)
Portfolio Summary: 127 holdings with a total value of $783,792,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 SELECT SECTOR SPDR TR SBI HEALTHCARE 10,000 66,230,000 8.45% Put
2 ALLERGAN PLC 177,100 48,138,000 6.14%
3 SPDR S&P 500 ETF TR PUT 2,451 46,969,000 5.99% Put
4 TEVA PHARMACEUTICAL INDS LTD 752,905 42,509,000 5.42%
5 SPDR S&P BIOTECH ETF 6,000 37,350,000 4.77% Put
6 ISHARES TR 1,000 30,333,000 3.87% Put
7 ELBIT SYS LTD 100,618 29,169,000 3.72%
8 BIOGEN INC 85,000 24,804,000 3.16%
9 PFIZER INC 574,013 18,030,000 2.30%
10 ABBVIE INC 327,000 17,792,000 2.27%
11 ORMAT TECHNOLOGIES INC 132,659 17,551,000 2.24%
12 SHIRE PLC 169,751 13,252,000 1.69%
13 BIOMARIN 125,000 13,165,000 1.68%
14 CELGENE CORP 120,000 12,980,000 1.66%
15 MYLAN N.V. 3,000 12,078,000 1.54% Call
16 GILEAD SCIENCES INC 120,000 11,783,000 1.50%
17 INCYTE 100,000 11,033,000 1.41%
18 CLOVIS ONCOLOGY INC 105,000 9,656,000 1.23%
19 BRISTOL MYERS SQUIBB CO 150,000 8,880,000 1.13%
20 CELLCOM ISRAEL LTD 357,452 8,793,000 1.12%
21 PERRIGO CO PLC 547 8,603,000 1.10% Call
22 MYLAN N V 200,000 8,052,000 1.03%
23 ACORDA THERAPEUTICS 270,000 7,158,000 0.91%
24 AMGEN INC 50,200 6,944,000 0.89%
25 HORIZON PHARMA PLC 3,500 6,937,000 0.89% Call
26 DEPOMED INC 360,000 6,786,000 0.87%
27 SELECT SECTOR SPDR TR 89,216 6,625,000 0.85%
28 VANDA PHARMACEUTICALS INC COM 513,390 5,791,000 0.74%
29 CHECK POINT SOFTWARE TECH LT 72,327 5,738,000 0.73%
30 ALEXION PHARMACEUTIC 35,000 5,474,000 0.70%
31 TESARO INC 117,500 4,712,000 0.60%
32 AMICUS THERAPEUTICS INC 310,000 4,337,000 0.55%
33 Egalet Corp 325,000 4,284,000 0.55%
34 PTC THERAPEUTICS INC 1,600 4,272,000 0.55% Call
35 INTRA CELLULAR THERAPIES INC COM 105,400 4,220,000 0.54%
36 VERTEX PHARMACEUT 40,000 4,166,000 0.53%
37 ALDER BIOPHARMACEUTICALS INC 125,000 4,095,000 0.52%
38 PORTOLA PHARMACEUTICALS INC 95,000 4,049,000 0.52%
39 HORIZON PHARMA PLC 200,000 3,964,000 0.51%
40 KEMPHARM INC 204,393 3,961,000 0.51%
41 GW PHARMACEUTICALS PLC 43,100 3,938,000 0.50%
42 UNITED THERAPEUTICS 28,840 3,785,000 0.48%
43 CONCERT PHARMACEUTICALS INC COM 200,000 3,754,000 0.48%
44 MACROGENICS INC 170,000 3,641,000 0.46%
45 STARBUCKS CORP 62,683 3,563,000 0.45%
46 RAPTOR PHARMACEUTICAL CORP 584,089 3,534,000 0.45%
47 ARRAY BIOPHARMA INC 7,500 3,420,000 0.44% Call
48 AMAG PHARMACEUTICALS INC COM 85,230 3,386,000 0.43%
49 BELLICUM PHARMACEUTICALS INC COM 231,514 3,364,000 0.43%
50 CATALYST PHARMACEUTICALS INC 1,100,000 3,300,000 0.42%
Page 1 of 3

Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001178913-15-003433, filed 2015.11.16).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.