| 1 |
NEA Management Company, LLC |
2,759,217 |
13,520,000 |
44.58% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
869,565 |
4,261,000 |
14.05% |
|
|
| 3 |
EVENTIDE ASSET MANAGEMENT, LLC |
865,526 |
4,241,000 |
13.98% |
|
|
| 4 |
QVT Financial LP |
381,477 |
1,711,000 |
5.64% |
|
|
| 5 |
WALL STREET ASSOCIATES |
241,536 |
1,184,000 |
3.90% |
|
|
| 6 |
AWM Investment Company, Inc. |
224,153 |
1,098,000 |
3.62% |
|
|
| 7 |
VANGUARD GROUP INC |
164,230 |
805,000 |
2.65% |
|
|
| 8 |
Candriam S.C.A. |
143,000 |
701,000 |
2.31% |
|
|
| 9 |
PERCEPTIVE ADVISORS LLC |
100,000 |
490,000 |
1.62% |
|
|
| 10 |
Alyeska Investment Group, L.P. |
100,000 |
490,000 |
1.62% |
|
|
| 11 |
ClariVest Asset Management LLC |
62,100 |
305,000 |
1.01% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
40,300 |
197,000 |
0.65% |
|
|
| 13 |
SII INVESTMENTS INC/WI |
29,406 |
144,000 |
0.47% |
|
|
| 14 |
STIFEL FINANCIAL CORP |
29,750 |
144,000 |
0.47% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
29,135 |
143,000 |
0.47% |
|
|
| 16 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
28,700 |
141,000 |
0.46% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
28,488 |
139,000 |
0.46% |
|
|
| 18 |
Kinsight, LLC |
21,318 |
104,000 |
0.34% |
|
|
| 19 |
BlackRock Fund Advisors |
20,990 |
103,000 |
0.34% |
|
|
| 20 |
TFS CAPITAL LLC |
16,753 |
82,000 |
0.27% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
13,236 |
65,000 |
0.21% |
|
|
| 22 |
Bank of New York Mellon Corp |
12,994 |
64,000 |
0.21% |
|
|
| 23 |
NEXTHERA CAPITAL LP |
12,714 |
62,000 |
0.20% |
|
|
| 24 |
NORTHERN TRUST CORP |
11,230 |
55,000 |
0.18% |
|
|
| 25 |
BANK OF AMERICA CORP /DE/ |
5,001 |
25,000 |
0.08% |
|
|
| 26 |
UBS Group AG |
4,625 |
23,000 |
0.08% |
|
|
| 27 |
Tower Research Capital LLC (TRC) |
1,765 |
9,000 |
0.03% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
1,428 |
7,000 |
0.02% |
|
|
| 29 |
BlackRock Investment Management, LLC |
1,432 |
7,000 |
0.02% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
763 |
4,000 |
0.01% |
|
|
| 31 |
BlackRock Japan Co. Ltd |
408 |
2,000 |
0.01% |
|
|
