| 1 |
WELLINGTON MANAGEMENT GROUP LLP |
5,240,212 |
31,074,000 |
45.98% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
2,667,500 |
15,818,000 |
23.41% |
|
|
| 3 |
RENAISSANCE TECHNOLOGIES LLC |
1,396,100 |
8,279,000 |
12.25% |
|
|
| 4 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
358,578 |
2,126,000 |
3.15% |
|
|
| 5 |
FIRST MANHATTAN CO. LLC. |
336,747 |
1,996,000 |
2.95% |
|
|
| 6 |
CITIGROUP INC |
283,505 |
1,681,000 |
2.49% |
|
|
| 7 |
Freedom Investment Management, Inc. |
228,350 |
1,354,000 |
2.00% |
|
|
| 8 |
ACUTA CAPITAL PARTNERS, LLC |
132,503 |
786,000 |
1.16% |
|
|
| 9 |
Invesco Ltd. |
114,045 |
676,000 |
1.00% |
|
|
| 10 |
DEUTSCHE BANK AG\ |
84,210 |
499,000 |
0.74% |
|
|
| 11 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
69,300 |
411,000 |
0.61% |
|
|
| 12 |
CREDIT SUISSE AG/ |
60,343 |
358,000 |
0.53% |
|
|
| 13 |
GLG Partners LP |
57,800 |
343,000 |
0.51% |
|
|
| 14 |
TWO SIGMA INVESTMENTS, LP |
56,994 |
338,000 |
0.50% |
|
|
| 15 |
MORGAN STANLEY |
50,272 |
298,000 |
0.44% |
|
|
| 16 |
PANAGORA ASSET MANAGEMENT INC |
42,816 |
254,000 |
0.38% |
|
|
| 17 |
TWO SIGMA ADVISERS, LP |
40,500 |
240,000 |
0.36% |
|
|
| 18 |
OMERS ADMINISTRATION Corp |
35,700 |
212,000 |
0.31% |
|
|
| 19 |
GUGGENHEIM CAPITAL LLC |
24,718 |
147,000 |
0.22% |
|
|
| 20 |
TFS CAPITAL LLC |
24,650 |
146,000 |
0.22% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
23,139 |
137,000 |
0.20% |
|
|
| 22 |
STATE STREET CORP |
16,912 |
100,000 |
0.15% |
|
|
| 23 |
Spark Investment Management LLC |
10,300 |
61,000 |
0.09% |
|
|
| 24 |
GENOVESE BURFORD & BROTHERS WEALTH & RETIREMENT PLAN MANAGEMENT, LLC |
9,950 |
59,000 |
0.09% |
|
|
| 25 |
Kassirer Asset Management Corp |
10,000 |
59,000 |
0.09% |
|
|
| 26 |
ADVISOR GROUP, INC. |
3,900 |
23,000 |
0.03% |
|
|
| 27 |
Walleye Trading LLC |
3,800 |
23,000 |
0.03% |
|
|
| 28 |
WOLVERINE TRADING LP /BD |
39 |
22,932 |
0.03% |
Call |
|
| 29 |
CUTLER GROUP LLC / CA |
2,900 |
17,000 |
0.03% |
|
|
| 30 |
Tower Research Capital LLC (TRC) |
2,376 |
14,000 |
0.02% |
|
|
| 31 |
WELLS FARGO & COMPANY/MN |
1,250 |
7,000 |
0.01% |
|
|
| 32 |
IFP ADVISORS, INC |
1,000 |
6,000 |
0.01% |
|
|
| 33 |
SIMPLEX TRADING, LLC |
700 |
4,000 |
0.01% |
|
|
| 34 |
JPMORGAN CHASE & CO |
522 |
3,000 |
0.00% |
|
|
| 35 |
CWM, LLC |
500 |
3,000 |
0.00% |
|
|
| 36 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
387 |
3,000 |
0.00% |
|
|
| 37 |
UBS Group AG |
106 |
1,000 |
0.00% |
|
|
| 38 |
WOLVERINE TRADING LP /BD |
147 |
864 |
0.00% |
|
|
