| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,303,535 | 146,509,000 | 11.17% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 6,267,382 | 125,724,000 | 9.59% | ||
| 3 | Palo Alto Investors LP | 4,854,631 | 97,384,000 | 7.43% | ||
| 4 | PAULSON & CO. INC. | 4,000,000 | 80,240,000 | 6.12% | ||
| 5 | VANGUARD GROUP INC | 3,022,301 | 60,627,000 | 4.62% | ||
| 6 | Invesco Ltd. | 2,572,209 | 51,599,000 | 3.94% | ||
| 7 | STATE STREET CORP | 2,284,242 | 45,820,000 | 3.49% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 2,190,023 | 43,933,000 | 3.35% | ||
| 9 | BlackRock Fund Advisors | 2,060,593 | 41,335,000 | 3.15% | ||
| 10 | Artal Group S.A. | 2,015,000 | 40,421,000 | 3.08% | ||
| 11 | TAMRO Capital Partners LLC | 1,889,738 | 37,908,000 | 2.89% | ||
| 12 | Clearbridge Investments, LLC | 1,571,874 | 31,532,000 | 2.40% | ||
| 13 | TimesSquare Capital Management, LLC | 1,526,195 | 30,615,000 | 2.34% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,369,906 | 27,480,000 | 2.10% | ||
| 15 | Artal Group S.A. | 1,100,000 | 22,066,000 | 1.68% | Call | |
| 16 | FRANKLIN RESOURCES INC | 1,001,100 | 20,082,000 | 1.53% | ||
| 17 | Granahan Investment Management, LLC | 972,380 | 19,506,000 | 1.49% | ||
| 18 | Tamarack Capital Management, LLC | 943,526 | 18,352,000 | 1.40% | ||
| 19 | PUTNAM INVESTMENTS LLC | 856,833 | 17,188,000 | 1.31% | ||
| 20 | DIMENSIONAL FUND ADVISORS LP | 758,698 | 15,222,000 | 1.16% | ||
| 21 | Neuberger Berman Group LLC | 654,699 | 13,133,000 | 1.00% | ||
| 22 | UBS AG | 650,063 | 13,040,000 | 0.99% | ||
| 23 | SOUTH TEXAS MONEY MANAGEMENT LTD | 631,082 | 12,660,000 | 0.97% | ||
| 24 | GLENMEDE TRUST CO NA | 619,525 | 12,427,000 | 0.95% | ||
| 25 | NORTHERN TRUST CORP | 608,336 | 12,203,000 | 0.93% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 545,500 | 10,942,000 | 0.83% | Call | |
| 27 | MORGAN STANLEY | 518,993 | 10,411,000 | 0.79% | ||
| 28 | Amici Capital, LLC | 415,230 | 8,330,000 | 0.64% | ||
| 29 | NORGES BANK | 387,708 | 7,777,000 | 0.59% | ||
| 30 | BARCLAYS PLC | 347,648 | 6,953,000 | 0.53% | ||
| 31 | Bank of New York Mellon Corp | 345,673 | 6,934,000 | 0.53% | ||
| 32 | MACQUARIE GROUP LTD | 307,170 | 6,162,000 | 0.47% | ||
| 33 | Broadfin Capital, LLC | 300,000 | 6,018,000 | 0.46% | ||
| 34 | CREDIT AGRICOLE S A | 282,092 | 5,659,000 | 0.43% | ||
| 35 | DAVIDE LEONE & PARTNERS INVESTMENT Co LLP | 272,000 | 5,456,000 | 0.42% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 258,891 | 5,193,000 | 0.40% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 255,657 | 5,128,000 | 0.39% | ||
| 38 | PICTET ASSET MANAGEMENT LTD | 255,000 | 5,115,000 | 0.39% | ||
| 39 | KING INVESTMENT ADVISORS INC/TX | 248,065 | 4,976,000 | 0.38% | ||
| 40 | JET CAPITAL INVESTORS L P | 239,175 | 4,798,000 | 0.37% | ||
| 41 | GOLDMAN SACHS GROUP INC | 237,734 | 4,769,000 | 0.36% | ||
| 42 | Healthcare Value Capital, LLC | 229,481 | 4,603,000 | 0.35% | ||
| 43 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 220,000 | 4,411,000 | 0.34% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 219,565 | 4,404,000 | 0.34% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 214,500 | 4,303,000 | 0.33% | Put | |
| 46 | D. E. Shaw & Co., Inc. | 209,200 | 4,197,000 | 0.32% | Put | |
| 47 | GOLDMAN SACHS GROUP INC | 205,800 | 4,128,000 | 0.31% | Call | |
| 48 | AMERIPRISE FINANCIAL INC | 199,097 | 3,994,000 | 0.30% | ||
| 49 | Jefferies Group LLC | 195,900 | 3,930,000 | 0.30% | Put | |
| 50 | LEVIN CAPITAL STRATEGIES, L.P. | 194,684 | 3,905,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
