| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | UBS Group AG | 50 | 1,000 | 0.00% | ||
| 2 | ROYAL BANK OF CANADA | 100 | 3,000 | 0.00% | ||
| 3 | MUFG Securities EMEA plc | 1,000 | 29,000 | 0.01% | ||
| 4 | Tower Research Capital LLC (TRC) | 1,250 | 36,000 | 0.01% | ||
| 5 | CI Global Investments Inc. | 7,500 | 217,000 | 0.06% | ||
| 6 | PICTON MAHONEY ASSET MANAGEMENT | 7,500 | 218,000 | 0.06% | SH | |
| 7 | SG Americas Securities, LLC | 7,760 | 225,000 | 0.06% | ||
| 8 | DekaBank Deutsche Girozentrale | 8,800 | 255,000 | 0.07% | ||
| 9 | ArrowMark Colorado Holdings LLC | 10,000 | 290,000 | 0.08% | ||
| 10 | JPMORGAN CHASE & CO | 10,000 | 290,000 | 0.08% | ||
| 11 | Point72 Asset Management, L.P. | 10,000 | 290,000 | 0.08% | ||
| 12 | Lisanti Capital Growth, LLC | 12,660 | 367,000 | 0.10% | ||
| 13 | EMERALD MUTUAL FUND ADVISERS TRUST | 14,980 | 434,000 | 0.12% | ||
| 14 | Ghost Tree Capital, LLC | 15,000 | 435,000 | 0.12% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 16,043 | 465,000 | 0.13% | ||
| 16 | OMERS ADMINISTRATION Corp | 16,200 | 469,000 | 0.13% | ||
| 17 | NORGES BANK | 20,000 | 580,000 | 0.16% | ||
| 18 | J. Goldman & Co LP | 20,000 | 580,000 | 0.16% | ||
| 19 | JANUS HENDERSON INVESTORS US LLC | 23,100 | 669,000 | 0.19% | ||
| 20 | Achievement Holdings L.P. | 24,500 | 710,000 | 0.20% | ||
| 21 | Alyeska Investment Group, L.P. | 30,000 | 869,000 | 0.24% | ||
| 22 | DEUTSCHE BANK AG\ | 30,604 | 886,000 | 0.25% | ||
| 23 | KORNITZER CAPITAL MANAGEMENT INC /KS | 32,470 | 941,000 | 0.26% | ||
| 24 | Laurion Capital Management LP | 35,000 | 1,014,000 | 0.28% | ||
| 25 | VANGUARD GROUP INC | 35,000 | 1,015,000 | 0.28% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 41,491 | 1,202,000 | 0.34% | ||
| 27 | CITADEL ADVISORS LLC | 48,875 | 1,416,000 | 0.40% | ||
| 28 | AMERICAN CENTURY COMPANIES INC | 50,000 | 1,449,000 | 0.41% | ||
| 29 | FEDERATED HERMES, INC. | 57,500 | 1,666,000 | 0.47% | ||
| 30 | TUDOR INVESTMENT CORP ET AL | 58,960 | 1,709,000 | 0.48% | ||
| 31 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 69,700 | 2,020,000 | 0.57% | ||
| 32 | Novo Holdings A/S | 75,000 | 2,174,000 | 0.61% | ||
| 33 | EATON VANCE MANAGEMENT | 75,000 | 2,174,000 | 0.61% | ||
| 34 | MORGAN STANLEY | 81,000 | 2,347,000 | 0.66% | ||
| 35 | BAMCO INC /NY/ | 92,600 | 2,684,000 | 0.75% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 108,235 | 3,137,000 | 0.88% | ||
| 37 | AMERIPRISE FINANCIAL INC | 111,550 | 3,233,000 | 0.91% | ||
| 38 | LORD, ABBETT & CO. LLC | 125,000 | 3,622,000 | 1.02% | ||
| 39 | NEXT CENTURY GROWTH INVESTORS LLC | 140,494 | 4,071,000 | 1.14% | ||
| 40 | FRANKLIN RESOURCES INC | 175,000 | 5,071,000 | 1.42% | ||
| 41 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,000 | 5,072,000 | 1.42% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 196,176 | 5,685,000 | 1.59% | ||
| 43 | Capital World Investors | 200,000 | 5,796,000 | 1.63% | ||
| 44 | Capital Research Global Investors | 250,000 | 7,245,000 | 2.03% | ||
| 45 | WELLS FARGO & COMPANY/MN | 489,345 | 14,181,000 | 3.98% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 500,434 | 14,503,000 | 4.07% | ||
| 47 | JENNISON ASSOCIATES LLC | 580,630 | 16,827,000 | 4.72% | ||
| 48 | GILDER GAGNON HOWE & CO LLC | 1,017,267 | 29,480,000 | 8.27% | ||
| 49 | FMR LLC | 1,268,579 | 36,763,000 | 10.31% | ||
| 50 | ORBIMED ADVISORS LLC | 2,897,937 | 83,982,000 | 23.56% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
