| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 2,897,938 | 84,504,000 | 12.21% | ||
| 2 | Versant Venture Management, LLC | 2,586,985 | 75,436,483 | 10.90% | ||
| 3 | Meritech Capital Associates III L.L.C. | 2,572,651 | 75,019,000 | 10.84% | ||
| 4 | Capital World Investors | 1,706,070 | 49,749,000 | 7.19% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,440,111 | 41,994,000 | 6.07% | ||
| 6 | GILDER GAGNON HOWE & CO LLC | 1,141,840 | 33,296,000 | 4.81% | ||
| 7 | FEDERATED HERMES, INC. | 1,083,419 | 31,592,000 | 4.56% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 984,112 | 28,697,000 | 4.15% | ||
| 9 | VANGUARD GROUP INC | 882,975 | 25,748,000 | 3.72% | ||
| 10 | FRAZIER MANAGEMENT LLC | 867,788 | 25,305,000 | 3.66% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 625,217 | 18,231,000 | 2.63% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 520,564 | 15,178,000 | 2.19% | ||
| 13 | NEXT CENTURY GROWTH INVESTORS LLC | 474,279 | 13,829,000 | 2.00% | ||
| 14 | WELLS FARGO & COMPANY/MN | 413,718 | 12,064,000 | 1.74% | ||
| 15 | BlackRock Fund Advisors | 394,202 | 11,495,000 | 1.66% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 376,497 | 10,979,000 | 1.59% | ||
| 17 | Cortina Asset Management, LLC | 335,452 | 9,782,000 | 1.41% | ||
| 18 | FULLER & THALER ASSET MANAGEMENT, INC. | 290,880 | 8,482,000 | 1.23% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 280,878 | 8,190,000 | 1.18% | ||
| 20 | Point72 Asset Management, L.P. | 264,200 | 7,704,000 | 1.11% | ||
| 21 | STATE STREET CORP | 253,087 | 7,381,000 | 1.07% | ||
| 22 | NORTHERN TRUST CORP | 180,826 | 5,272,000 | 0.76% | ||
| 23 | Pier Capital, LLC | 178,517 | 5,206,000 | 0.75% | ||
| 24 | MARSHALL WACE, LLP | 139,766 | 4,076,000 | 0.59% | ||
| 25 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 138,157 | 4,029,000 | 0.58% | ||
| 26 | CITADEL ADVISORS LLC | 137,809 | 4,018,000 | 0.58% | ||
| 27 | Iguana Healthcare Management, LLC | 135,000 | 3,937,000 | 0.57% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 124,400 | 3,628,000 | 0.52% | ||
| 29 | Atika Capital Management LLC | 113,000 | 3,296,000 | 0.48% | ||
| 30 | AMERIPRISE FINANCIAL INC | 112,007 | 3,266,000 | 0.47% | ||
| 31 | JPMORGAN CHASE & CO | 109,732 | 3,200,000 | 0.46% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 107,552 | 3,136,000 | 0.45% | ||
| 33 | PRICE T ROWE ASSOCIATES INC /MD/ | 102,028 | 2,975,000 | 0.43% | ||
| 34 | Informed Momentum Co LLC | 100,015 | 2,916,000 | 0.42% | ||
| 35 | MORGAN STANLEY | 86,468 | 2,521,000 | 0.36% | ||
| 36 | Spark Investment Management LLC | 84,400 | 2,461,000 | 0.36% | ||
| 37 | Bank of New York Mellon Corp | 82,790 | 2,413,000 | 0.35% | ||
| 38 | Regis Management CO LLC | 80,703 | 2,353,000 | 0.34% | ||
| 39 | C WorldWide Group Holding A/S | 75,000 | 2,187,000 | 0.32% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 71,474 | 2,084,000 | 0.30% | ||
| 41 | Calvert Investment Management, Inc. | 62,497 | 1,822,000 | 0.26% | ||
| 42 | BlackRock Investment Management, LLC | 61,777 | 1,801,000 | 0.26% | ||
| 43 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 60,963 | 1,778,000 | 0.26% | ||
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 56,867 | 1,658,000 | 0.24% | ||
| 45 | HAMILTON LANE ADVISORS LLC | 67,666 | 1,648,000 | 0.24% | ||
| 46 | DEUTSCHE BANK AG\ | 55,754 | 1,624,000 | 0.23% | ||
| 47 | Numeric Investors LLC | 50,308 | 1,467,000 | 0.21% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,096 | 1,257,000 | 0.18% | ||
| 49 | EMERALD ACQUISITION LTD. | 39,872 | 1,163,000 | 0.17% | ||
| 50 | Employees Retirement System of Texas | 38,000 | 1,108,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
