| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Versant Venture Management, LLC | 3,136,232 | 52,876,871 | 15.25% | ||
| 2 | Meritech Capital Associates III L.L.C. | 3,026,677 | 51,030,000 | 14.72% | ||
| 3 | ORBIMED ADVISORS LLC | 2,897,938 | 48,859,000 | 14.10% | ||
| 4 | FRAZIER MANAGEMENT LLC | 2,603,362 | 43,893,000 | 12.66% | ||
| 5 | Capital World Investors | 1,286,633 | 21,693,000 | 6.26% | ||
| 6 | FEDERATED HERMES, INC. | 1,083,419 | 18,266,000 | 5.27% | ||
| 7 | VANGUARD GROUP INC | 798,675 | 13,466,000 | 3.88% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 697,890 | 11,766,000 | 3.39% | ||
| 9 | LORD, ABBETT & CO. LLC | 637,348 | 10,746,000 | 3.10% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 613,949 | 10,352,000 | 2.99% | ||
| 11 | WELLS FARGO & COMPANY/MN | 613,471 | 10,344,000 | 2.98% | ||
| 12 | GILDER GAGNON HOWE & CO LLC | 497,874 | 8,394,000 | 2.42% | ||
| 13 | Cortina Asset Management, LLC | 266,370 | 4,491,000 | 1.30% | ||
| 14 | NEXT CENTURY GROWTH INVESTORS LLC | 215,252 | 3,629,000 | 1.05% | ||
| 15 | Pier Capital, LLC | 174,880 | 2,948,000 | 0.85% | ||
| 16 | BlackRock Fund Advisors | 163,692 | 2,760,000 | 0.80% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 157,994 | 2,664,000 | 0.77% | ||
| 18 | Archon Capital Management LLC | 135,300 | 2,281,000 | 0.66% | ||
| 19 | Portolan Capital Management, LLC | 132,711 | 2,238,000 | 0.65% | ||
| 20 | Iguana Healthcare Management, LLC | 125,000 | 2,108,000 | 0.61% | ||
| 21 | Calvert Investment Management, Inc. | 113,289 | 1,910,000 | 0.55% | ||
| 22 | Novo Holdings A/S | 101,106 | 1,705,000 | 0.49% | ||
| 23 | STATE STREET CORP | 93,937 | 1,584,000 | 0.46% | ||
| 24 | NORTHERN TRUST CORP | 81,730 | 1,378,000 | 0.40% | ||
| 25 | JPMORGAN CHASE & CO | 73,246 | 1,235,000 | 0.36% | ||
| 26 | AMERIPRISE FINANCIAL INC | 65,393 | 1,103,000 | 0.32% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 57,637 | 972,000 | 0.28% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 41,932 | 706,000 | 0.20% | ||
| 29 | HAMILTON LANE ADVISORS LLC | 40,220 | 678,000 | 0.20% | ||
| 30 | STONERIDGE INVESTMENT PARTNERS LLC | 40,002 | 674,000 | 0.19% | ||
| 31 | Employees Retirement System of Texas | 38,000 | 641,000 | 0.18% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,513 | 632,000 | 0.18% | ||
| 33 | PRICE T ROWE ASSOCIATES INC /MD/ | 35,341 | 596,000 | 0.17% | ||
| 34 | DEUTSCHE BANK AG\ | 31,241 | 525,000 | 0.15% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 30,754 | 519,000 | 0.15% | ||
| 36 | Bank of New York Mellon Corp | 29,287 | 493,000 | 0.14% | ||
| 37 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 27,007 | 455,000 | 0.13% | ||
| 38 | BlackRock Investment Management, LLC | 24,214 | 408,000 | 0.12% | ||
| 39 | BAMCO INC /NY/ | 23,925 | 403,000 | 0.12% | ||
| 40 | RUSSELL FRANK CO/ | 23,785 | 401,000 | 0.12% | ||
| 41 | MORGAN STANLEY | 23,324 | 394,000 | 0.11% | ||
| 42 | A.R.T. Advisors, LLC | 22,580 | 380,000 | 0.11% | ||
| 43 | MENTA CAPITAL LLC | 21,533 | 363,000 | 0.10% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,044 | 355,000 | 0.10% | ||
| 45 | Jupiter Investment Management Ltd | 19,208 | 323,000 | 0.09% | ||
| 46 | CITADEL ADVISORS LLC | 17,979 | 303,000 | 0.09% | ||
| 47 | Spark Investment Management LLC | 17,800 | 300,000 | 0.09% | ||
| 48 | GSA CAPITAL PARTNERS LLP | 16,100 | 271,000 | 0.08% | ||
| 49 | TFS CAPITAL LLC | 16,055 | 271,000 | 0.08% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,945 | 252,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
